Search Results - "Sadee, Wolfgang"

Ligand-Free Signaling of G-Protein-Coupled Receptors: Physiology, Pharmacology, and Genetics by Sadee, Wolfgang

“…G-protein-coupled receptors (GPCRs) are ubiquitous sensors and regulators of cellular functions. Each GPCR exists in complex aggregates with multiple resting…”
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CYP3A4 intronic SNP rs35599367 (CYP3A422) alters RNA splicing by Wang, Danxin, Sadee, Wolfgang

“…Cytochrome P450 3A4 (CYP3A4) metabolizes 30–50% of clinically used drugs. Large interperson variability in CYP3A4 activity affects response to CYP3A4 substrate…”
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Innate Immune Gene Polymorphisms in Tuberculosis by AZAD, Abul K, SADEE, Wolfgang, SCHLESINGER, Larry S

“…Classifications Services IAI Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Interpreting coronary artery disease GWAS results: A functional genomics approach assessing biological significance by Hartmann, Katherine, Seweryn, Michał, Sadee, Wolfgang

“…Genome-wide association studies (GWAS) have implicated 58 loci in coronary artery disease (CAD). However, the biological basis for these associations, the…”
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Cystine-glutamate transporter SLC7A11 in cancer chemosensitivity and chemoresistance by YING HUANG, ZUNYAN DAI, BARBACIORU, Catalin, SADEE, Wolfgang

“…SLC7A11 (xCT), together with SLC3A2 (4F2hc), encodes the heterodimeric amino acid transport system x(c)-, which mediates cystine-glutamate exchange and thereby…”
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Ligand-Free Signaling of G-Protein-Coupled Receptors: Relevance to μ Opioid Receptors in Analgesia and Addiction by Sadee, Wolfgang, McKew, John C

“…Numerous G-protein-coupled receptors (GPCRs) display ligand-free basal signaling with potential physiological functions, a target in drug development. As an…”
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Polymorphisms in human dopamine D2 receptor gene affect gene expression, splicing, and neuronal activity during working memory by Zhang, Ying, Bertolino, Alessandro, Fazio, Leonardo, Blasi, Giuseppe, Rampino, Antonio, Romano, Raffaella, Lee, Mei-Ling T, Xiao, Tao, Papp, Audrey, Wang, Danxin, Sadée, Wolfgang

“…Subcortical dopamine D2 receptor (DRD2) signaling is implicated in cognitive processes and brain disorders, but the effect of DRD2 variants remains ambiguous…”
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Biased Opioid Antagonists as Modulators of Opioid Dependence: Opportunities to Improve Pain Therapy and Opioid Use Management by Sadee, Wolfgang, Oberdick, John, Wang, Zaijie

“…Opioid analgesics are effective pain therapeutics but they cause various adverse effects and addiction. For safer pain therapy, biased opioid agonists…”
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Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement by Wang, Danxin, Chen, Huizi, Momary, Kathryn M., Cavallari, Larisa H., Johnson, Julie A., Sadée, Wolfgang

“…Warfarin dose requirements have been associated with 2 main haplotypes in VKORC1, but the responsible polymorphisms remain unknown. To search for regulatory…”
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Allelic Expression Imbalance of Human mu Opioid Receptor (OPRM1) Caused by Variant A118G by Zhang, Ying, Wang, Danxin, Johnson, Andrew D., Papp, Audrey C., Sadée, Wolfgang

“…As a primary target for opioid drugs and peptides, the mu opioid receptor (OPRM1) plays a key role in pain perception and addiction. Genetic variants of OPRM1…”
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Drug Therapy and Personalized Health Care: Pharmacogenomics in Perspective by Sadee, Wolfgang

“…Issue Title: Special Issue Dedicated to the Celebration of the Journal's 25th Anniversary…”
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Searching for polymorphisms that affect gene expression and mRNA processing: example ABCB1 (MDR1) by Wang, Danxin, Sadée, Wolfgang

“…Cis-acting genetic variations can affect the amount and structure of mRNA/protein. Genomic surveys indicate that polymorphisms affecting transcription and mRNA…”
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Membrane transporters and channels in chemoresistance and -sensitivity of tumor cells by Huang, Ying, Sadée, Wolfgang

“…Membrane transporters play important roles in mediating chemosensitivity and -resistance of tumor cells. ABC transporters, such as ABCB1/MDR1, ABCC1/MRP1 and…”
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Combined genetic influence of the nicotinic receptor gene cluster CHRNA5/A3/B4 on nicotine dependence by Lee, Sung-Ha, Ahn, Woo-Young, Seweryn, Michał, Sadee, Wolfgang

“…The CHRNA5/A3/B4 gene locus is associated with nicotine dependence and other smoking related disorders. While the non-synonymous CHRNA5 variant rs16969968…”
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Allelic mRNA expression of X-linked monoamine oxidase a (MAOA) in human brain: dissection of epigenetic and genetic factors by Pinsonneault, Julia K., Papp, Audrey C., Sadée, Wolfgang

“…A pVNTR repeat polymorphism located in the promoter region of the X-linked MAOA gene has been associated with mental disorders. To explore the effect of…”
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AmpliSeq transcriptome analysis of human alveolar and monocyte-derived macrophages over time in response to Mycobacterium tuberculosis infection by Papp, Audrey C, Azad, Abul K, Pietrzak, Maciej, Williams, Amanda, Handelman, Samuel K, Igo, Jr, Robert P, Stein, Catherine M, Hartmann, Katherine, Schlesinger, Larry S, Sadee, Wolfgang

“…Human alveolar macrophages (HAM) are primary bacterial niche and immune response cells during Mycobacterium tuberculosis (M.tb) infection, and human blood…”
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Multidrug resistance polypeptide 1 (MDR1, ABCB1) variant 3435C>T affects mRNA stability by Wang, Danxin, Johnson, Andrew D, Papp, Audrey C, Kroetz, Deanna L, Sadée, Wolfgang

“…OBJECTIVESABCB1 (multidrug resistance 1 polypeptide, MDR1, Pgp) is a multispecific efflux transporter of drugs and xenobiotics. Among numerous polymorphisms in…”
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MicroRNAs modulate the chemosensitivity of tumor cells by Blower, Paul E, Chung, Ji-Hyun, Verducci, Joseph S, Lin, Shili, Park, Jong-Kook, Dai, Zunyan, Liu, Chang-Gong, Schmittgen, Thomas D, Reinhold, William C, Croce, Carlo M, Weinstein, John N, Sadee, Wolfgang

“…MicroRNAs are strongly implicated in such processes as development, carcinogenesis, cell survival, and apoptosis. It is likely, therefore, that they can also…”
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ABCB5-mediated doxorubicin transport and chemoresistance in human malignant melanoma by FRANK, Natasha Y, MARGARYAN, Armen, YING HUANG, SCHATTON, Tobias, WAAGA-GASSER, Ana Maria, GASSER, Martin, SAYEGH, Mohamed H, SADEE, Wolfgang, FRANK, Markus H

“…Enhanced drug efflux mediated by ABCB1 P-glycoprotein and related ATP-binding cassette transporters is one of several mechanisms of multidrug resistance…”
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Strategies and Methods for Research on Sex Differences in Brain and Behavior by Becker, Jill B, Arnold, Arthur P, Berkley, Karen J, Blaustein, Jeffrey D, Eckel, Lisa A, Hampson, Elizabeth, Herman, James P, Marts, Sherry, Sadee, Wolfgang, Steiner, Meir, Taylor, Jane, Young, Elizabeth

“…Female and male brains differ. Differences begin early during development due to a combination of genetic and hormonal events and continue throughout the…”
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