Search Results - "Sadat‐Shirazi, Mitra"
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Therapeutic potential of stem cells for treatment of neurodegenerative diseases
Published in Biotechnology letters (01-07-2020)“…Neurodegenerative diseases are caused by a loss of neurons within the peripheral or central nervous system. Inadequate repairability in the central nervous…”
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2
Cocaine- and amphetamine-regulated transcript (CART): A multifaceted neuropeptide
Published in Peptides (New York, N.Y. : 1980) (01-12-2018)“…•Cocaine Amphetamine-Regulated Transcript (CART) was discovered 35 years ago, and it was found that CART is expressed in various brain areas.•The main…”
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3
The effect of morphine administration on GluN3B NMDA receptor subunit mRNA expression in rat brain
Published in Acta neurobiologiae experimentalis (28-03-2024)“…Opioid addiction is critically dependent on the activation of N‑methyl‑D‑aspartate (NMDA) receptors, which are widely found in the mesocorticolimbic system…”
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4
Tannic acid protects aged brain against cerebral hypoperfusion via modulation of Nrf2 and inflammatory pathways
Published in Neuroscience letters (20-11-2021)“…[Display omitted] •Tannic acid improves brain metabolism and blood flow in oligemia.•Tannic acid decreases neurodegeneration level after hypoperfusion.•Tannic…”
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Effect of tramadol on apoptosis and synaptogenesis in hippocampal neurons: The possible role of µ‐opioid receptor
Published in Drug development research (01-09-2022)“…Tramadol is a synthetic opioid with centrally acting analgesic activity that alleviates moderate to severe pain and treats withdrawal symptoms of the other…”
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Exercise can restore behavioural and molecular changes of intergenerational morphine effects
Published in Addiction biology (01-03-2022)“…In our previous studies, the offspring of morphine‐exposed parents (MEO) showed pharmacological tolerance to the morphine's reinforcing effect. According to…”
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Oxidative stress enzymes are changed in opioid abusers and multidrug abusers
Published in Journal of clinical neuroscience (01-02-2020)“…•Lipid peroxidation was increased in the prefrontal cortex pure-opioid and multi-drug abusers.•SOD activity was decreased in the prefrontal cortex pure-opioid…”
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8
Inter/Transgenerational Effects of Drugs of Abuse: A Scoping Review
Published in CNS & neurological disorders drug targets (01-01-2023)“…Drug addiction is a chronic relapsing disorder that makes it a global problem. Genetics and environmental factors are the two most important factors that make…”
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Evaluation of dynorphin and kappa-opioid receptor level in the human blood lymphocytes and plasma: Possible role as a biomarker in severe opioid use disorder
Published in Drug and alcohol dependence (01-12-2019)“…•The PBLs expression of the pPDYN mRNA is increased in SOD, MMT, and NA subjects.•The PBLs level of the PDYN peptide is elevated in SOD, MMT, and NA…”
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10
Toxic effect of calcium/calmodulin kinase II on anxiety behavior, neuronal firing and plasticity in the male offspring of morphine-abstinent rats
Published in Behavioural brain research (01-10-2020)“…Studies have shown that epigenetic changes such as alteration in histone acetylation and DNA methylation in various brain regions play an essential role in…”
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Influence of citicoline on citalopram-induced antidepressant activity in depressive-like symptoms in male mice
Published in Physiology & behavior (15-10-2018)“…Depression is associated with significant functional disabilities. Application of new drugs which could enhance the effectiveness of antidepressants drug and…”
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12
The role of cannabinoid 1 receptor in the nucleus accumbens on tramadol induced conditioning and reinstatement
Published in Life sciences (1973) (01-11-2020)“…Aims: Previous investigations demonstrated that tramadol, as a painkiller, similar to morphine induces tolerance and dependence. Furthermore, the cannabinoid…”
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13
The role of lateral habenula NMDA receptors in tramadol-induced conditioning
Published in Behavioural pharmacology (01-08-2023)“…The role of the lateral habenula (LHb) as a hub for receiving and relaying signals from the limbic system to serotonergic, dopaminergic, and norepinephrinergic…”
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Effect of rat parental morphine exposure on passive avoidance memory and morphine conditioned place preference in male offspring
Published in Physiology & behavior (01-02-2018)“…Drug addiction is a chronic disorder resulted from complex interaction of genetic, environmental, and developmental factors. Epigenetic mechanisms play an…”
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Adult rat morphine exposure changes morphine preference, anxiety, and the brain expression of dopamine receptors in male offspring
Published in International journal of developmental neuroscience (01-10-2018)“…•F1 male progeny of morphine-exposed parents had a greater preference for morphine.•F1 male progeny of morphine-exposed parents had more anxiety-like…”
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Parental morphine exposure affects repetitive grooming actions and marble burying behavior in the offspring: Potential relevance for obsessive-compulsive like behavior
Published in European journal of pharmacology (15-12-2019)“…Family, adoption and twin studies have highlighted the significant role of heritable influences on individual differences in opioid addiction. Meanwhile,…”
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Alcohol: Epigenome alteration and inter/transgenerational effect
Published in Alcohol (Fayetteville, N.Y.) (01-06-2024)“…While DNA serves as the fundamental genetic blueprint for an organism, it is not a static entity. Gene expression, the process by which genetic information is…”
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Effects of Morphine and Maternal Care on Behaviors and Protein Expression of Male Offspring
Published in Neuroscience (01-07-2021)“…•Morphine-exposure ten days before conception induced molecular and behavioral changes in the offspring.•Poor maternal caring affected behaviors and induced…”
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Activation of D1-like dopamine receptors is involved in the impairment of spatial memory in the offspring of morphine-abstinent rats
Published in Neuroscience research (01-09-2020)“…•Parental morphine exposure impaired spatial memory in the male offspring.•Intra-hippocampal injection of SCH improved spatial memory in the…”
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Comparison and interaction of morphine and CB1 agonist conditioned place preference in the rat model of early life stress
Published in International journal of developmental neuroscience (01-05-2021)“…Early life stress (ELS) disrupts brain development and subsequently affects physical and psychological health. ELS has been associated with an increased risk…”
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