Search Results - "Sadat, Sams M. A"

Potentiating Antigen Specific Immune Response by Targeted Delivery of the PLGA-Based Model Cancer Vaccine by Jahan, Sheikh Tasnim, Sadat, Sams M. A, Yarahmadi, Mehran, Haddadi, Azita

“…Targeted delivery of vaccine has the potential to localize the therapeutic agent to a target tissue with minimum side-effects. This article presents the…”
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Targeted Therapeutic Nanoparticles: An Immense Promise to Fight against Cancer by Jahan, Sheikh Tasnim, Sadat, Sams M. A., Walliser, Matthew, Haddadi, Azita

“…In nanomedicine, targeted therapeutic nanoparticle (NP) is a virtual outcome of nanotechnology taking the advantage of cancer propagation pattern. Tying up all…”
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Development of Self-Associating SN-38-Conjugated Poly(ethylene oxide)-Poly(ester) Micelles for Colorectal Cancer Therapy by Sadat, Sams M. A., Vakili, Mohammad Reza, Paiva, Igor M., Weinfeld, Michael, Lavasanifar, Afsaneh

“…The clinical use of 7-ethyl-10-hydroxy-camptothecin (SN-38), which is the active metabolite of irinotecan, has been hampered because of its practical…”
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Nano-Delivery of a Novel Inhibitor of Polynucleotide Kinase/Phosphatase (PNKP) for Targeted Sensitization of Colorectal Cancer to Radiation-Induced DNA Damage by Sadat, Sams M A, Wuest, Melinda, Paiva, Igor M, Munira, Sirazum, Sarrami, Nasim, Sanaee, Forughalsadat, Yang, Xiaoyan, Paladino, Marco, Binkhathlan, Ziyad, Karimi-Busheri, Feridoun, Martin, Gary R, Jirik, Frank R, Murray, David, Gamper, Armin M, Hall, Dennis G, Weinfeld, Michael, Lavasanifar, Afsaneh

“…Inhibition of the DNA repair enzyme polynucleotide kinase/phosphatase (PNKP) increases the sensitivity of cancer cells to DNA damage by ionizing radiation…”
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Local innate responses and protective immunity after intradermal immunization with bovine viral diarrhea virus E2 protein formulated with a combination adjuvant in cattle by Sadat, Sams M.A, Snider, Marlene, Garg, Ravendra, Brownlie, Robert, van Drunen Littel-van den Hurk, Sylvia

“…Abstract Bovine viral diarrhea virus (BVDV) is one of the most serious pathogens in cattle. Recently, we developed a novel adjuvant platform (TriAdj) that…”
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Synergistic Nanomedicine Delivering Topoisomerase I Toxin (SN-38) and Inhibitors of Polynucleotide Kinase 3′-Phosphatase (PNKP) for Enhanced Treatment of Colorectal Cancer by Sadat, Sams M. A., Vakili, Mohammad Reza, Abd-El Hafeez, Sara I., Paladino, Marco, Hall, Dennis G., Weinfeld, Michael, Lavasanifar, Afsaneh

“…Inhibitors of a DNA repair enzyme known as polynucleotide kinase 3′-phosphatase (PNKP) are expected to show synergistic cytotoxicity in combination with…”
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A synthetically lethal nanomedicine delivering novel inhibitors of polynucleotide kinase 3′-phosphatase (PNKP) for targeted therapy of PTEN-deficient colorectal cancer by Sadat, Sams M.A., Paiva, Igor M., Shire, Zahra, Sanaee, Forughalsadat, Morgan, Timothy D.R., Paladino, Marco, Karimi-Busheri, Feridoun, Mani, Rajam S., Martin, Gary R., Jirik, Frank R., Hall, Dennis G., Weinfeld, Michael, Lavasanifar, Afsaneh

“…Phosphatase and TENsin homolog deleted on chromosome 10 (PTEN) is a major tumor-suppressor protein that is lost in up to 75% of aggressive colorectal cancers…”
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Nano-pharmaceutical formulations for targeted drug delivery against HER2 in breast cancer by Sadat, Sams M A, Saeidnia, Soodabeh, Nazarali, Adil J, Haddadi, Azita

“…Nanotechnology has revolutionized fundamental opportunities for higher specific drug delivery with minimum side effects. Since its inception, the goal of…”
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Design and immunological evaluation of anti-CD205-tailored PLGA-based nanoparticulate cancer vaccine by Jahan, Sheikh Tasnim, Sadat, Sams Ma, Haddadi, Azita

“…The aim of this research was to develop a targeted antigen-adjuvant assembled delivery system that will enable dendritic cells (DCs) to efficiently mature to…”
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