Search Results - "Sacksteder, Katherine A"

Applying the Triangle Taste Test to Assess Differences between Low Sodium Salts and Common Salt: Evidence from Peru by Saavedra-Garcia, Lorena, Bernabe-Ortiz, Antonio, Gilman, Robert H, Diez-Canseco, Francisco, Cárdenas, María Kathia, Sacksteder, Katherine A, Miranda, J Jaime

“…In resourced-constrained settings, daily cooking practices are still the norm. Replacing sodium in regular salt to produce potassium-enriched salts are…”
Get full text

PEX19 Binds Multiple Peroxisomal Membrane Proteins, Is Predominantly Cytoplasmic, and Is Required for Peroxisome Membrane Synthesis by Sacksteder, Katherine A., Jones, Jacob M., South, Sarah T., Li, Xiaoling, Liu, Yifei, Gould, Stephen J.

“…Peroxisomes are components of virtually all eukaryotic cells. While much is known about peroxisomal matrix protein import, our understanding of how peroxisomal…”
Get full text

Effect of salt substitution on community-wide blood pressure and hypertension incidence by Bernabe-Ortiz, Antonio, Sal y Rosas, Víctor G., Ponce-Lucero, Vilarmina, Cárdenas, María K., Carrillo-Larco, Rodrigo M., Diez-Canseco, Francisco, Pesantes, M. Amalia, Sacksteder, Katherine A., Gilman, Robert H., Miranda, J. Jaime

“…Replacement of regular salt with potassium-enriched substitutes reduces blood pressure in controlled situations, mainly among people with hypertension. We…”
Get full text

Discovery and development of SQ109: a new antitubercular drug with a novel mechanism of action by Sacksteder, Katherine A, Protopopova, Marina, Barry, 3rd, Clifton E, Andries, Koen, Nacy, Carol A

“…Existing drugs have limited efficacy against the rising threat of drug-resistant TB, have significant side effects, and must be given in combinations of four…”
Get more information

Generation of a novel nucleic acid-based reporter system to detect phenotypic susceptibility to antibiotics in Mycobacterium tuberculosis by Mulvey, Matthew C, Sacksteder, Katherine A, Einck, Leo, Nacy, Carol A

“…We designed, constructed, and evaluated a prototype novel reporter system comprised of two functional cassettes: (i) the SP6 RNA polymerase gene under…”
Get full text

Implementation of foot thermometry plus mHealth to prevent diabetic foot ulcers: study protocol for a randomized controlled trial by Lazo-Porras, Maria, Bernabe-Ortiz, Antonio, Sacksteder, Katherine A, Gilman, Robert H, Malaga, German, Armstrong, David G, Miranda, J Jaime

“…Diabetic foot neuropathy (DFN) is one of the most important complications of diabetes mellitus; its early diagnosis and intervention can prevent foot ulcers…”
Get full text

Training and Capacity Building in LMIC for Research in Heart and Lung Diseases: The NHLBI-UnitedHealth Global Health Centers of Excellence Program by Bloomfield, Gerald S, Xavier, Denis, Belis, Deshirée, Alam, Dewan, Davis, Patricia, Dorairaj, Prabhakaran, Ghannem, Hassen, Gilman, Robert H, Kamath, Deepak, Kimaiyo, Sylvester, Levitt, Naomi, Martinez, Homero, Mejicano, Gabriela, Miranda, J Jaime, Koehlmoos, Tracey Perez, Rabadán-Diehl, Cristina, Ramirez-Zea, Manuel, Rubinstein, Adolfo, Sacksteder, Katherine A, Steyn, Krisela, Tandon, Nikhil, Vedanthan, Rajesh, Wolbach, Tracy, Wu, Yangfeng, Yan, Lijing L

“…Stemming the tide of noncommunicable diseases (NCDs) worldwide requires a multipronged approach. Although much attention has been paid to disease control…”
Get full text

Sodium and Potassium Consumption in a Semi-Urban Area in Peru: Evaluation of a Population-Based 24-Hour Urine Collection by Carrillo-Larco, Rodrigo M, Saavedra-Garcia, Lorena, Miranda, J Jaime, Sacksteder, Katherine A, Diez-Canseco, Francisco, Gilman, Robert H, Bernabe-Ortiz, Antonio

“…Despite the negative effects of high sodium and low potassium consumption on cardiovascular health, their consumption has not been quantified in sites…”
Get full text

Parental body mass index and blood pressure are associated with higher body mass index and blood pressure in their adult offspring: a cross‐sectional study in a resource‐limited setting in northern Peru by Carrillo‐Larco, Rodrigo M., Bernabé‐Ortiz, Antonio, Sal y Rosas, Víctor G., Sacksteder, Katherine A., Diez‐Canseco, Francisco, Cárdenas, María K., Gilman, Robert H., Miranda, J. Jaime

“…Objectives High body mass index (BMI) and blood pressure (BP) are major contributors to the high burden of non‐communicable diseases in adulthood. Individual…”
Get full text

Launching a salt substitute to reduce blood pressure at the population level: a cluster randomized stepped wedge trial in Peru by Bernabe-Ortiz, Antonio, Diez-Canseco, Francisco, Gilman, Robert H, Cárdenas, María K, Sacksteder, Katherine A, Miranda, J Jaime

“…Controlling hypertension rates and maintaining normal blood pressure, particularly in resource-constrained settings, represent ongoing challenges of effective…”
Get full text

The Solution Structure of Antigen MPT64 from Mycobacterium tuberculosis Defines a New Family of Beta-Grasp Proteins by Wang, Zhonghua, Potter, Belinda M., Gray, Amanda M., Sacksteder, Katherine A., Geisbrecht, Brian V., Laity, John H.

“…The MPT64 protein and its homologs form a highly conserved family of secreted proteins with unknown function that are found within the pathogenic Mycobacteria…”
Get full text

Inhibitors of COPI and COPII Do Not Block PEX3-Mediated Peroxisome Synthesis by South, Sarah T., Sacksteder, Katherine A., Li, Xiaoling, Liu, Yifei, Gould, Stephen J.

“…In humans, defects in peroxisome biogenesis are the cause of lethal diseases typified by Zellweger syndrome. Here, we show that inactivating mutations in human…”
Get full text

PEX12 Interacts with PEX5 and PEX10 and Acts Downstream of Receptor Docking in Peroxisomal Matrix Protein Import by Chang, Chia-Che, Warren, Daniel S., Sacksteder, Katherine A., Gould, Stephen J.

“…Peroxisomal matrix protein import requires PEX12, an integral peroxisomal membrane protein with a zinc ring domain at its carboxy terminus. Mutations in human…”
Get full text

Training and Capacity Building in LMIC for Research in Heart and Lung Diseases by Bloomfield, Gerald S, Xavier, Denis, Belis, Deshirée, Alam, Dewan, Davis, Patricia, Prabhakaran, Dorairaj, Ghannem, Hassen, Gilman, Robert H, Kamath, Deepak, Kimaiyo, Sylvester, Levitt, Naomi, Martinez, Homero, Mejicano, Gabriela, Miranda, J. Jaime, Koehlmoos, Tracey Perez, Rabadán-Diehl, Cristina, Ramirez-Zea, Manuel, Rubinstein, Adolfo, Sacksteder, Katherine A, Steyn, Krisela, Tandon, Nikhil, Vedanthan, Rajesh, Wolbach, Tracy, Wu, Yangfeng, Yan, Lijing L

“…Stemming the tide of noncommunicable diseases (NCDs) worldwide requires a multipronged approach. Although much attention has been paid to disease control…”
Get full text

THE GENETICS OF PEROXISOME BIOGENESIS by Sacksteder, Katherine A, Gould, Stephen J

“…The segregation of metabolic functions within discrete organelles is a hallmark of eukaryotic cells. These compartments allow for the concentration of related…”
Get full text

Identification of PAHX , a Refsum disease gene by Mihalik, Stephanie J, Morrell, James C, Kim, Do, Sacksteder, Katherine A, Watkins, Paul A, Gould, Stephen J

“…Refsum disease is an autosomal recessive disorder characterized by retinitis pigmentosa, peripheral polyneuropathy, cerebellar ataxia and increased…”
Get full text

MCD Encodes Peroxisomal and Cytoplasmic Forms of Malonyl-CoA Decarboxylase and Is Mutated in Malonyl-CoA Decarboxylase Deficiency by Sacksteder, Katherine A., Morrell, James C., Wanders, Ronald J.A., Matalon, Reuben, Gould, Stephen J.

“…Malonyl-CoA decarboxylase (MCD) catalyzes the proton-consuming conversion of malonyl-CoA to acetyl-CoA and CO2. Although defects in MCD activity are associated…”
Get full text

Design and optimization of a recombinant system for large-scale production of the MPT64 antigen from Mycobacterium tuberculosis by Geisbrecht, Brian V., Nikonenko, Boris, Samala, Rowena, Nakamura, Reiko, Nacy, Carol A., Sacksteder, Katherine A.

“…Early clinical trials of a potential new tuberculosis (TB) diagnostic, the Patch Test for Active TB (PTAT), used MPB64 protein that was purified from the spent…”
Get full text

New tuberculosis vaccine development by Sacksteder, Katherine A, Nacy, Carol A

“…Tuberculosis (TB) is a devastating disease that kills more than three million people each year. Of these, 0.9 million are co-infected with HIV and numbers of…”
Get more information

Heavy-Atom Isotope Effects on the Hydrazinolysis of Methyl Formate by Marlier, John F, Haptonstall, Brandy A, Johnson, Amanda J, Sacksteder, Katherine A

“…The carbonyl carbon, carbonyl oxygen, and nitrogen nucleophile isotope effects were measured for the hydrazinolysis of methyl formate at pH 8 and 10. At pH 8,…”
Get full text