Search Results - "Sacks, S H"

Identification of omentin mRNA in human epicardial adipose tissue: comparison to omentin in subcutaneous, internal mammary artery periadventitial and visceral abdominal depots by Fain, J.N, Sacks, H.S, Buehrer, B, Bahouth, S.W, Garrett, E, Wolf, R.Y, Carter, R.A, Tichansky, D.S, Madan, A.K

“…Objective: The purpose of this study was to determine the relative distribution of omentin and visfatin mRNA in human epicardial, peri-internal mammary, upper…”
Get full text

Coexpression of Donor Peptide/Recipient MHC Complex and Intact Donor MHC: Evidence for a Link between the Direct and Indirect Pathways by Brown, K., Sacks, S. H., Wong, W.

“…T lymphocytes recognize foreign antigens presented by donor or recipient cells through the direct and indirect pathways respectively. This raises the question…”
Get full text

Cervicovaginal Human Papillomavirus Infection in Human Immunodeficiency Virus-1(HIV)-Positive and High-Risk HIV-Negative Women by Palefsky, Joel M., Minkoff, Howard, Kalish, Leslie A., Levine, Alexandra, Sacks, Henry S., Garcia, Patricia, Young, Mary, Melnick, Sandra, Miotti, Paolo, Burk, Robert

“…BACKGROUND: Human papillomavirus (HPV) infection is associated with precancerous cervical squamous intraepithelial lesions commonly seen among women infected…”
Get full text

Toll‐like receptors TLR2 and TLR4 initiate the innate immune response of the renal tubular epithelium to bacterial products by Chowdhury, P., Sacks, S. H., Sheerin, N. S.

“…Summary Renal tubular epithelial cells (TECs) respond diffusely to local infection, with the release of multiple cytokines, chemokines and other factors that…”
Get full text

Urinary tract infections: new insights into a common problem by Kucheria, R, Dasgupta, P, Sacks, S H, Khan, M S, Sheerin, N S

“…This review discusses recent advances in the understanding of how the common pathogen, uropathogenic Escherichia coli, interacts with the host to lead to…”
Get full text

SPECT/CT Lymphoscintigraphy of Heterotopic Cardiac Grafts Reveals Novel Sites of Lymphatic Drainage and T Cell Priming by Brown, K., Badar, A., Sunassee, K., Fernandes, M. A., Shariff, H., Jurcevic, S., Blower, P. J., Sacks, S. H., Mullen, G. E. D., Wong, W.

“…The normal function of lymphatic vessels is to facilitate the trafficking of antigen presenting cells to draining lymph nodes where they evoke an immune…”
Get full text

Reimplantation of the ureter after unilateral ureteral obstruction provides a model that allows functional evaluation by Tapmeier, T.T., Brown, K.L., Tang, Z., Sacks, S.H., Sheerin, N.S., Wong, W.

“…Experimental unilateral ureteral obstruction (UUO) is widely used to study renal fibrosis; however, renal injury can only be scored semiobjectively by…”
Get full text

The membrane attack complex, C5b‐9, up regulates collagen gene expression in renal tubular epithelial cells by ABE, K., LI, K., SACKS, S. H., SHEERIN, N. S.

“…SUMMARY Evidence suggesting a direct role for proteinuria in the pathogenesis of renal tubulointerstitial fibrosis is accumulating. However the mechanism by…”
Get full text

Late Low‐Dose Steroid Withdrawal in Renal Transplant Recipients Increases Bone Formation and Bone Mineral Density by Farmer, C.K.T., Hampson, G., Abbs, I.C., Hilton, R.M., Koffman, C.G., Fogelman, I., Sacks, S.H.

“…Corticosteroids have been the most widely used immunosuppressive agents since the first clinical transplantation in the 1950s. There are few studies of late…”
Get full text

An Antibody Combination That Targets Activated T Cells Extends Graft Survival in Sensitized Recipients by Greenlaw, R. E., Gardner, N. J., Farrar, C. A., Shariff, H., Sacks, S. H., Yagita, H., Simpson, E., Jurcevic, S.

“…Memory T cells are the very essence of adaptive immunity with their rapid and efficient response to antigen rechallenge and long‐term persistence. However, it…”
Get full text

Protection against anti‐glomerular basement membrane (GBM)‐mediated nephritis in C3‐ and C4‐deficient mice by SHEERIN, N. S., SPRINGALL, T., CARROLL, M. C., HARTLEY, B., SACKS, S. H.

“…Mice rendered completely deficient of the complement components C3 or C4 were used to determine the influence of complement activation in the heterologous…”
Get full text

Mechanisms of nephrotoxicity by CAMPISTOL, J. M, SACKS, S. H

“…Approximately 20 years ago, cyclosporine was introduced as an immunosuppressive agent to prevent rejection of transplanted tissue. Its impact on…”
Get full text

Higher incidence of HCV in females compared to males who inject drugs: A systematic review and meta‐analysis by Esmaeili, A., Mirzazadeh, A., Carter, G. M., Esmaeili, A., Hajarizadeh, B., Sacks, H. S., Page, K. A.

“…Women who inject drugs have been shown to have higher incidence of HIV and risk behaviours than men, but there are conflicting reports about hepatitis C virus…”
Get full text

Intrarenal synthesis of complement by Zhou, Wuding, Marsh, James E., Sacks, Steven H.

“…Intrarenal synthesis of complement. During the past decade, research has shown that the kidney has the capacity to synthesize most of the activation pathway…”
Get full text

Regulation of complement C3 and C4 synthesis in human peritoneal mesothelial cells by peritoneal dialysis fluid by TANG, S., LEUNG, J. C. K., CHAN, L. Y. Y., TSANG, A. W. L., CHEN, C. X. R., ZHOU, W., LAI, K. N., SACKS, S. H.

“…SUMMARY Although complement is activated in the peritoneal cavity during chronic peritoneal dialysis (PD), little is known about its role in peritoneal defence…”
Get full text

Decisions on Innovation or Research for Devastating Disease by Andreae, M. H., Shah, L. D., Shepherd, V., Sheehan, M., Sacks, H. S., Rhodes, R.

Get full text

Complement—here, there and everywhere, but what about the transplanted organ? by Montero, R.M, Sacks, S.H, Smith, R.A

“…Highlights • Importance of peripheral and central complement. • Complement in Ischaemia-Reperfusion Injury in Kidney Transplantation can be targeted. •…”
Get full text

Thrombalexins: Cell‐Localized Inhibition of Thrombin and Its Effects in a Model of High‐Risk Renal Transplantation by Karegli, J., Melchionna, T., Farrar, C. A., Greenlaw, R., Smolarek, D., Horsfield, C., Charif, R., McVey, J. H., Dorling, A., Sacks, S. H., Smith, R. A. G.

“…Allograft transplantation into sensitized recipients with antidonor antibodies results in accelerated antibody‐mediated rejection (AMR), complement activation,…”
Get full text

Preferential suppression of CXCR4-specific strains of HIV-1 by antiviral therapy by Philpott, S, Weiser, B, Anastos, K, Kitchen, C M, Robison, E, Meyer, 3rd, W A, Sacks, H S, Mathur-Wagh, U, Brunner, C, Burger, H

“…To initiate infection, HIV-1 requires a primary receptor, CD4, and a secondary receptor, principally the chemokine receptor CCR5 or CXCR4. Coreceptor usage…”
Get full text

Apical proteins stimulate complement synthesis by cultured human proximal tubular epithelial cells by TANG, S, SHEERIN, N. S, WUDING ZHOU, BROWN, Z, SACKS, S. H

“…There is increasing evidence to suggest that the renal tubular epithelium is important in the pathogenesis of progressive renal failure resulting from…”
Get full text