Search Results - "Sackmann, Christopher"

TDP-43 Is Efficiently Transferred Between Neuron-Like Cells in a Manner Enhanced by Preservation of Its N-Terminus but Independent of Extracellular Vesicles by Sackmann, Christopher, Sackmann, Valerie, Hallbeck, Martin

“…The misfolding of transactive response DNA-binding protein (TDP-43) is a major contributor to the pathogenesis of TDP-43 proteinopathies, including amyotrophic…”
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Cardiac glycoside-mediated turnover of Na, K-ATPases as a rational approach to reducing cell surface levels of the cellular prion protein by Mehrabian, Mohadeseh, Wang, Xinzhu, Eid, Shehab, Yan, Bei Qi, Grinberg, Mark, Siegner, Murdock, Sackmann, Christopher, Sulman, Muhammad, Zhao, Wenda, Williams, Declan, Schmitt-Ulms, Gerold

“…It is widely anticipated that a reduction of brain levels of the cellular prion protein (PrP C ) can prolong survival in a group of neurodegenerative diseases…”
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The cellular prion protein interacts with and promotes the activity of Na,K-ATPases by Williams, Declan, Mehrabian, Mohadeseh, Arshad, Hamza, Eid, Shehab, Sackmann, Christopher, Zhao, Wenda, Wang, Xinzhu, Ghodrati, Farinaz, Verkuyl, Claire E, Watts, Joel C, Schmitt-Ulms, Gerold

“…The prion protein (PrP) is best known for its ability to cause fatal neurodegenerative diseases in humans and animals. Here, we revisited its molecular…”
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Aggregated Alpha-Synuclein Transfer Efficiently between Cultured Human Neuron-Like Cells and Localize to Lysosomes by Domert, Jakob, Sackmann, Christopher, Severinsson, Emelie, Agholme, Lotta, Bergström, Joakim, Ingelsson, Martin, Hallbeck, Martin

“…Parkinson's disease and other alpha-synucleinopathies are progressive neurodegenerative diseases characterized by aggregates of misfolded alpha-synuclein…”
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Inhibition of nSMase2 Reduces the Transfer of Oligomeric α-Synuclein Irrespective of Hypoxia by Sackmann, Valerie, Sinha, Maitrayee Sardar, Sackmann, Christopher, Civitelli, Livia, Bergström, Joakim, Ansell-Schultz, Anna, Hallbeck, Martin

“…Recently, extracellular vesicles (EVs), such as exosomes, have been proposed to play an influential role in the cell-to-cell spread of neurodegenerative…”
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Oligomeric amyloid-β induces early and widespread changes to the proteome in human iPSC-derived neurons by Sackmann, Christopher, Hallbeck, Martin

“…Alzheimer’s disease (AD) is the most common form of dementia globally and is characterized by aberrant accumulations of amyloid-beta (Aβ) and tau proteins…”
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Binding of α-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes by Reyes, Juan F., Sackmann, Christopher, Hoffmann, Alana, Svenningsson, Per, Winkler, Jürgen, Ingelsson, Martin, Hallbeck, Martin

“…The intercellular transfer of alpha-synuclein (α-syn) has been implicated in the progression of Parkinson’s disease (PD) and multiple system atrophy (MSA). The…”
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Binding of [alpha]-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes by Reyes, Juan F, Sackmann, Christopher, Hoffmann, Alana, Svenningsson, Per, Winkler, Jürgen, Ingelsson, Ma, Hallbeck, Ma

“…The intercellular transfer of alpha-synuclein ([alpha]-syn) has been implicated in the progression of Parkinson's disease (PD) and multiple system atrophy…”
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Binding of alfa-synuclein oligomers to Cx32 facilitates protein uptake and transfer in neurons and oligodendrocytes by Reyes, Juan F., Sackmann, Christopher, Hoffmann, Alana, Svenningsson, Per, Winkler, Jürgen, Ingelsson, Martin, Hallbeck, Martin

“…The intercellular transfer of alpha-synuclein (-syn) has been implicated in the progression of Parkinson's disease (PD) and multiple system atrophy (MSA). The…”
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Somatostatin slows Aβ plaque deposition in aged APPNL-F/NL-F mice by blocking Aβ aggregation by Williams, Declan, Yan, Bei Qi, Wang, Hansen, Negm, Logine, Sackmann, Christopher, Verkuyl, Claire, Rezai-Stevens, Vanessa, Eid, Shehab, Vediya, Nimit, Sato, Christine, Watts, Joel C., Wille, Holger, Schmitt-Ulms, Gerold

“…The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid β peptide (Aβ) in Alzheimer’s disease (AD)…”
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Investigation of the Intercellular Transmission of α-Synuclein, Amyloid-β and TDP-43 by Sackmann, Christopher

“…Neurodegenerative diseases such as Alzheimer’s disease (AD), Parkinson’s disease (PD), frontotemporal lobar dementia (FTLD) and amyotrophic lateral sclerosis…”
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Anti-inflammatory (M2) macrophage media reduce transmission of oligomeric amyloid beta in differentiated SH-SY5Y cells by Sackmann, Valerie, Ansell, Anna, Sackmann, Christopher, Lund, Harald, Harris, Robert A., Hallbeck, Martin, Nilsberth, Camilla

“…Neuroinflammation plays an influential role in Alzheimer's disease (AD), although the mechanisms underlying this phenomenon remain largely unknown. Microglia…”
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P3‐044: THE ELECTROPHYSIOLOGICAL PROPERTIES OF DIFFERENTIATED SH‐SY5Y CELLS USED TO UNDERSTAND THE EFFECT OF PROPAGATION OF NEURODEGENERATIVE PROTEINS by Juarez, Esri Hazael, Sackmann, Christopher, Granseth, Björn, Hallbeck, Martin

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THE ELECTROPHYSIOLOGICAL PROPERTIES OF DIFFERENTIATED SH-SY5Y CELLS USED TO UNDERSTAND THE EFFECT OF PROPAGATION OF NEURODEGENERATIVE PROTEINS by Juarez, Esri Hazael, Sackmann, Christopher, Granseth, Björn, Hallbeck, Martin

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Somatostatin slows Aβ plaque deposition in aged APP NL-F/NL-F mice by blocking Aβ aggregation by Williams, Declan, Yan, Bei Qi, Wang, Hansen, Negm, Logine, Sackmann, Christopher, Verkuyl, Claire, Rezai-Stevens, Vanessa, Eid, Shehab, Vediya, Nimit, Sato, Christine, Watts, Joel C, Wille, Holger, Schmitt-Ulms, Gerold

“…The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid β peptide (Aβ) in Alzheimer's disease (AD)…”
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Somatostatin slows Aβ plaque deposition in aged APP NL-F/NL-F mice by blocking Aβ aggregation by Declan Williams, Bei Qi Yan, Hansen Wang, Logine Negm, Christopher Sackmann, Claire Verkuyl, Vanessa Rezai-Stevens, Shehab Eid, Nimit Vediya, Christine Sato, Joel C. Watts, Holger Wille, Gerold Schmitt-Ulms

“…Abstract The neuroendocrine peptide somatostatin (SST) has long been thought of as influencing the deposition of the amyloid β peptide (Aβ) in Alzheimer’s…”
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Neutral Sphingomyelinase 2 influences transfer of oligomeric alphasynuclein through exosomal pathway and its relation to oxidative stress by Sackmann, Valerie, Sinha, Maitrayee Sardar, Civitelli, Livia, Sackmann, Christopher, Hallbeck, Martin

“…Background: Progressive accumulation and cell-to-cell transfer of a-synuclein (a-syn) aggregates is a characteristic feature ofParkinson's disease (PD)…”
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The effect of retromer dysfunction on the clearance and transfer of intra- and extra-cellular beta-amyloid and alpha-synuclein in neurons by Albargothy, Nazira, Schultz, Anna Ansell, Sackmann, Christopher, Hallbeck, Martin

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