Search Results - "Sack, M."

Cumulative Haploinsufficiency and Triplosensitivity Drive Aneuploidy Patterns and Shape the Cancer Genome by Davoli, Teresa, Xu, Andrew Wei, Mengwasser, Kristen E., Sack, Laura M., Yoon, John C., Park, Peter J., Elledge, Stephen J.

“…Aneuploidy has been recognized as a hallmark of cancer for more than 100 years, yet no general theory to explain the recurring patterns of aneuploidy in cancer…”
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Intranasal oxytocin reduces provoked symptoms in female patients with posttraumatic stress disorder despite exerting sympathomimetic and positive chronotropic effects in a randomized controlled trial by Sack, M, Spieler, D, Wizelman, L, Epple, G, Stich, J, Zaba, M, Schmidt, U

“…Posttraumatic stress disorder (PTSD) is a severe psychiatric disease accompanied by neuroendocrine changes such as adrenergic overdrive and hence an elevated…”
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Platelet mitochondrial dysfunction is evident in type 2 diabetes in association with modifications of mitochondrial anti-oxidant stress proteins by Avila, C, Huang, R J, Stevens, M V, Aponte, A M, Tripodi, D, Kim, K Y, Sack, M N

“…Mitochondrial dysfunction and oxidative stress in insulin responsive tissues is implicated in the pathogenesis of type 2 diabetes. Whether these perturbations…”
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Predictors of complex PTSD: the role of trauma characteristics, dissociation, and comorbid psychopathology by Guzman Torres, E, Krause-Utz, A, Sack, M

“…Complex Posttraumatic Stress Disorder (CPTSD) has previously been associated with earlier trauma onset, repeated interpersonal traumatization, more…”
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Interspecies analysis of MYC targets identifies tRNA synthetases as mediators of growth and survival in MYC-overexpressing cells by Zirin, Jonathan, Ni, Xiaochun, Sack, Laura M., Yang-Zhou, Donghui, Hu, Yanhui, Brathwaite, Roderick, Bulyk, Martha L., Elledge, Stephen J., Perrimon, Norbert

“…Aberrant MYC oncogene activation is one of the most prevalent characteristics of cancer. By overlapping datasets of Drosophila genes that are…”
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Optimal nitrogen supply as a key to increased and sustained production of a monoclonal full-size antibody in BY-2 suspension culture by Holland, T, Sack, M, Rademacher, T, Schmale, K, Altmann, F, Stadlmann, J, Fischer, R, Hellwig, S

“…Plant cell cultures have been used as expression hosts for recombinant proteins for over two decades. The quality of plant cell culture-produced proteins such…”
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Brief psychodynamic interpersonal psychotherapy for patients with multisomatoform disorder: randomised controlled trial by Sattel, H., Lahmann, C., Gündel, H., Guthrie, E., Kruse, J., Noll-Hussong, M., Ohmann, C., Ronel, J., Sack, M., Sauer, N., Schneider, G., Henningsen, P.

“…Multisomatoform disorder is characterised by severe and disabling bodily symptoms, and pain is one of the most common and impairing of these. Furthermore,…”
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Absence of changes in GABA concentrations with age and gender in the human anterior cingulate cortex: A MEGA-PRESS study with symmetric editing pulse frequencies for macromolecule suppression by Aufhaus, E., Weber-Fahr, W., Sack, M., Tunc-Skarka, N., Oberthuer, G., Hoerst, M., Meyer-Lindenberg, A., Boettcher, U., Ende, G.

“…Despite MEGA‐PRESS being a robust method for editing the GABA resonance, there are macromolecule resonances at the same chemical shift that are coedited with…”
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Improvements of a Branch Module for an Inductive Voltage Adder Based on Measurements and Circuit Simulations by Ruf, J., Barnes, M. J., Kramer, T., Sack, M.

“…For future upgrades of some CERN kicker systems, doubling of the driving current by replacing a matched impedance by a short circuit termination is of…”
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The affinity of antipsychotic drugs to dopamine and serotonin 5-HT 2 receptors determines their effects on prefrontal-striatal functional connectivity by Tollens, F, Gass, N, Becker, R, Schwarz, A J, Risterucci, C, Künnecke, B, Lebhardt, P, Reinwald, J, Sack, M, Weber-Fahr, W, Meyer-Lindenberg, A, Sartorius, A

“…One of the major challenges of cross-species translation in psychiatry is the identification of quantifiable brain phenotypes linked to drug efficacy and/or…”
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The affinity of antipsychotic drugs to dopamine and serotonin 5-HT2 receptors determines their effects on prefrontal-striatal functional connectivity by Tollens, F., Gass, N., Becker, R., Schwarz, A.J., Risterucci, C., Künnecke, B., Lebhardt, P., Reinwald, J., Sack, M., Weber-Fahr, W., Meyer-Lindenberg, A., Sartorius, A.

“…One of the major challenges of cross-species translation in psychiatry is the identification of quantifiable brain phenotypes linked to drug efficacy and/or…”
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Signal-to-noise ratio of a mouse brain (13) C CryoProbe™ system in comparison with room temperature coils: spectroscopic phantom and in vivo results by Sack, M, Wetterling, F, Sartorius, A, Ende, G, Weber-Fahr, W

“…MRI and MRS in small rodents demand very high sensitivity. Cryogenic transmit/receive radiofrequency probes (CryoProbes) designed for (1) H MRI of mouse brain…”
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Affinity purification of a framework 1 engineered mouse/human chimeric IgA2 antibody from tobacco by Boes, A., Spiegel, H., Delbrück, H., Fischer, R., Schillberg, S., Sack, M.

“…Complex multimeric proteins such as dimeric and secretory immunoglobulin A (IgA) can be difficult to produce in heterologous systems, although this has been…”
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Chlamydia trachomatis-Induced Alterations in the Host Cell Proteome Are Required for Intracellular Growth by Olive, Andrew J., Haff, Madeleine G., Emanuele, Michael J., Sack, Laura M., Barker, Jeffrey R., Elledge, Stephen J., Starnbach, Michael N.

“…Intracellular pathogens directly alter host cells in order to replicate and survive. While infection-induced changes in host transcription can be readily…”
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Trauma-related disorders in patients with borderline personality disorders. Results of a multicenter study by Sack, M, Sachsse, U, Overkamp, B, Dulz, B

“…There is current controversy about the diagnostic overlap between personality disorders and trauma-related disorders. Applying a multicenter study design,…”
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Recent progress in plantibody technology by Stoger, E, Sack, M, Nicholson, L, Fischer, R, Christou, P

“…Antibodies are an important class of proteins that can be used for the prevention, treatment and diagnosis of many diseases. Consequently, there is an intense…”
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Mitochondrial aldehyde dehydrogenase attenuates hyperoxia-induced cell death through activation of ERK/MAPK and PI3K-Akt pathways in lung epithelial cells by Xu, Dong, Guthrie, Jill R, Mabry, Sherry, Sack, Thomas M, Truog, William E

“…Oxygen toxicity is one of the major risk factors in the development of the chronic lung disease or bronchopulmonary dysplasia in premature infants. Using…”
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Oestrogen and inhibition of oxidation of low-density lipoproteins in postmenopausal women by Sack, M N, Rader, D J, Cannon, 3rd, R O

“…Oxidative modification of low-density lipoprotein (LDL) may be atherogenic. We studied the time of onset of LDL oxidation (lag) in 18 postmenopausal women…”
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Retrospective Analysis of Real-World Outcomes of 10 kHz SCS in Patients with Upper Limb and Neck Pain by Sayed, Dawood, Salmon, John, Khan, Talal W, Sack, Andrew M, Braun, Ted, Barnard, Adele, Rotte, Anand

“…Patients living with chronic upper limb and neck (ULN) pain are reliant on often ineffective therapies as they face limited options for effective long-term…”
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GLTSCR2/PICT1 links mitochondrial stress and Myc signaling by Yoon, John C., Ling, Alvin J. Y., Isik, Meltem, Lee, Dong-Young Donna, Steinbaugh, Michael J., Sack, Laura M., Boduch, Abigail N., Blackwell, T. Keith, Sinclair, David A., Elledge, Stephen J.

“…Mitochondrial defects underlie a multitude of human diseases. Genetic manipulation of mitochondrial regulatory pathways represents a potential therapeutic…”
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