Search Results - "Sack, David"

Updated global burden of cholera in endemic countries by Ali, Mohammad, Nelson, Allyson R, Lopez, Anna Lena, Sack, David A

“…The global burden of cholera is largely unknown because the majority of cases are not reported. The low reporting can be attributed to limited capacity of…”
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Current Progress in Developing Subunit Vaccines against Enterotoxigenic Escherichia coli-Associated Diarrhea by Zhang, Weiping, Sack, David A

“…Diarrhea continues to be a leading cause of death in children <5 years of age, and enterotoxigenic Escherichia coli (ETEC) is the most common bacterial cause…”
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Genetic fusions of a CFA/I/II/IV MEFA (multiepitope fusion antigen) and a toxoid fusion of heat-stable toxin (STa) and heat-labile toxin (LT) of enterotoxigenic Escherichia coli (ETEC) retain broad anti-CFA and antitoxin antigenicity by Ruan, Xiaosai, Sack, David A, Zhang, Weiping

“…Immunological heterogeneity has long been the major challenge in developing broadly effective vaccines to protect humans and animals against bacterial and…”
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Preclinical Characterization of Immunogenicity and Efficacy against Diarrhea from MecVax, a Multivalent Enterotoxigenic E. coli Vaccine Candidate by Seo, Hyesuk, Garcia, Carolina, Ruan, Xiaosai, Duan, Qiangde, Sack, David A, Zhang, Weiping

“…There are no vaccines licensed for enterotoxigenic Escherichia coli (ETEC), a leading cause of diarrhea for children in developing countries and international…”
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Enhancing immune responses to oral vaccines: still an enigma by Sack, David A

“…[...]Church and colleagues found that there was no general strategy that seems to substantially improve the serological responses to these oral vaccines…”
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A polyvalent multiepitope protein cross-protects against Vibrio cholerae infection in rabbit colonization and passive protection models by Upadhyay, Ipshita, Li, Siqi, Ptacek, Galen, Seo, Hyesuk, Sack, David A, Zhang, Weiping

“…Using epitope- and structure-based multiepitope fusion antigen vaccinology platform, we constructed a polyvalent protein immunogen that presents antigenic…”
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Protection against cholera from killed whole-cell oral cholera vaccines: a systematic review and meta-analysis by Bi, Qifang, Ferreras, Eva, Pezzoli, Lorenzo, Legros, Dominique, Ivers, Louise C, Date, Kashmira, Qadri, Firdausi, Digilio, Laura, Sack, David A, Ali, Mohammad, Lessler, Justin, Luquero, Francisco J, Azman, Andrew S, Cavailler, Philippe, Date, Kashmira, Sreenivasan, Nandini, Matzger, Helen, Luquero, Francisco, Grais, Rebecca, Wiesner, Lale, Ko, Melissa, Rouzier, Vanessa, Peak, Corey, Qadri, Firdausi, Landegger, Justine, Lynch, Julia, Azman, Andrew, Sack, David, Henkens, Myriam, Ciglenecki, Iza, Ivers, Louise, Diggle, Emma, Weiss, Mitchell, Hinman, Alan, Maina, Kahindo, Mirza, Imran, Gimeno, Guillermo, Levine, Myron

“…Killed whole-cell oral cholera vaccines (kOCVs) are becoming a standard cholera control and prevention tool. However, vaccine efficacy and direct effectiveness…”
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The Impact of a One-Dose versus Two-Dose Oral Cholera Vaccine Regimen in Outbreak Settings: A Modeling Study by Azman, Andrew S, Luquero, Francisco J, Ciglenecki, Iza, Grais, Rebecca F, Sack, David A, Lessler, Justin

“…In 2013, a stockpile of oral cholera vaccine (OCV) was created for use in outbreak response, but vaccine availability remains severely limited. Innovative…”
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Intradermally Administered Enterotoxigenic Escherichia coli Vaccine Candidate MecVax Induces Functional Serum Immunoglobulin G Antibodies against Seven Adhesins (CFA/I and CS1 through CS6) and Both Toxins (STa and LT) by Garcia, Carolina Y, Seo, Hyesuk, Sack, David A, Zhang, Weiping

“…There are no vaccines licensed for enterotoxigenic Escherichia coli (ETEC), a leading bacterial cause of children's diarrhea and travelers' diarrhea. MecVax, a…”
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A multi-epitope fusion antigen candidate vaccine for Enterotoxigenic Escherichia coli is protective against strain B7A colonization in a rabbit model by Jones, Jr, Richard M, Seo, Hyesuk, Zhang, Weiping, Sack, David A

“…Enterotoxigenic Escherichia coli (ETEC) strains are a leading cause of children's and travelers' diarrhea. Developing effective vaccines against this…”
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Diagnostic techniques for rapid detection of Vibrio cholerae O1/O139 by Ramamurthy, Thandavarayan, Das, Bhabatosh, Chakraborty, Subhra, Mukhopadhyay, Asish K, Sack, David A.

“…•Cholera is a major public health problem in several Asian and African countries.•Effective management is crucial in controlling the epidemics of cholera.•RDTs…”
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Identification of burden hotspots and risk factors for cholera in India: An observational study by Ali, Mohammad, Sen Gupta, Sanjukta, Arora, Nisha, Khasnobis, Pradeep, Venkatesh, Srinivas, Sur, Dipika, Nair, Gopinath B, Sack, David A, Ganguly, Nirmal K

“…Even though cholera has existed for centuries and many parts of the country have sporadic, endemic and epidemic cholera, it is still an under-recognized health…”
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Progress and hurdles in the development of vaccines against enterotoxigenic Escherichia coli in humans by Zhang, Weiping, Sack, David A

“…Diarrhea is the second leading cause of death in children younger than 5 years. Enterotoxigenic Escherichia coli (ETEC) strains are the most common bacterial…”
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The First Use of the Global Oral Cholera Vaccine Emergency Stockpile: Lessons from South Sudan by Abubakar, Abdinasir, Azman, Andrew S, Rumunu, John, Ciglenecki, Iza, Helderman, Trina, West, Haley, Lessler, Justin, Sack, David A, Martin, Stephen, Perea, William, Legros, Dominique, Luquero, Francisco J

“…* A global oral cholera vaccine (OCV) stockpile was established in 2013 to improve rapid access to the vaccine in outbreaks and emergencies in which cholera…”
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The quality of drinking and domestic water from the surface water sources (lakes, rivers, irrigation canals and ponds) and springs in cholera prone communities of Uganda: an analysis of vital physicochemical parameters by Bwire, Godfrey, Sack, David A, Kagirita, Atek, Obala, Tonny, Debes, Amanda K, Ram, Malathi, Komakech, Henry, George, Christine Marie, Orach, Christopher Garimoi

“…Water is the most abundant resource on earth, however water scarcity affects more than 40% of people worldwide. Access to safe drinking water is a basic human…”
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Efficacy of pentavalent rotavirus vaccine against severe rotavirus gastroenteritis in infants in developing countries in Asia: a randomised, double-blind, placebo-controlled trial by Zaman, K, PhD, Anh, Dang Duc, PhD, Victor, John C, Dr, Shin, Sunheang, MS, Yunus, Md, MBBS, Dallas, Michael J, PhD, Podder, Goutam, MBBS, Thiem, Vu Dinh, MD, Mai, Le Thi Phuong, MD, Luby, Stephen P, MD, Tho, Le Huu, MD, Coia, Michele L, BS, Lewis, Kristen, MPH, Rivers, Stephen B, MBA, Sack, David A, Prof, Schödel, Florian, MD, Steele, A Duncan, PhD, Neuzil, Kathleen M, MD, Ciarlet, Max, PhD

“…Summary Background Rotavirus vaccine has proved effective for prevention of severe rotavirus gastroenteritis in infants in developed countries, but no efficacy…”
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Effectiveness of a live oral human rotavirus vaccine after programmatic introduction in Bangladesh: A cluster-randomized trial by Zaman, K, Sack, David A, Neuzil, Kathleen M, Yunus, Mohammad, Moulton, Lawrence H, Sugimoto, Jonathan D, Fleming, Jessica A, Hossain, Ilias, Arifeen, Shams El, Azim, Tasnim, Rahman, Mustafizur, Lewis, Kristen D C, Feller, Andrea J, Qadri, Firdausi, Halloran, M Elizabeth, Cravioto, Alejandro, Victor, John C

“…Rotavirus vaccines are now globally recommended by the World Health Organization (WHO), but in early 2009 WHO's Strategic Advisory Group of Experts on…”
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A broadly immunogenic polyvalent Shigella multiepitope fusion antigen protein protects against Shigella sonnei and Shigella flexneri lethal pulmonary challenges in mice by Li, Siqi, Anvari, Shaghayegh, Ptacek, Galen, Upadhyay, Ipshita, Kaminski, Robert W., Sack, David A., Zhang, Weiping

“…ABSTRACT There are no licensed vaccines for Shigella , a leading cause of children’s diarrhea and a common etiology of travelers’ diarrhea. To develop a…”
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Integration of water, sanitation and hygiene intervention delivery at health facilities with a reactive ring vaccination programme to reduce cholera by George, Christine Marie, Sack, David A

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Molecular characterization of Vibrio cholerae responsible for cholera epidemics in Uganda by PCR, MLVA and WGS by Bwire, Godfrey, Sack, David A, Almeida, Mathieu, Li, Shan, Voeglein, Joseph B, Debes, Amanda Kay, Kagirita, Atek, Buyinza, Ambrose Wabwire, Orach, Christopher Garimoi, Stine, O Colin

“…For almost 50 years sub-Saharan Africa, including Uganda, has experienced several outbreaks due to Vibrio cholerae. Our aim was to determine the genetic…”
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