Search Results - "Sachsenheimer, Timo"

Inositol triphosphate-triggered calcium release blocks lipid exchange at endoplasmic reticulum-Golgi contact sites by Malek, Mouhannad, Wawrzyniak, Anna M., Koch, Peter, Lüchtenborg, Christian, Hessenberger, Manuel, Sachsenheimer, Timo, Jang, Wonyul, Brügger, Britta, Haucke, Volker

“…Vesicular traffic and membrane contact sites between organelles enable the exchange of proteins, lipids, and metabolites. Recruitment of tethers to contact…”
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Sterol transfer by atypical cholesterol-binding NPC2 proteins in coral-algal symbiosis by Hambleton, Elizabeth Ann, Jones, Victor Arnold Shivas, Maegele, Ira, Kvaskoff, David, Sachsenheimer, Timo, Guse, Annika

“…Reef-building corals depend on intracellular dinoflagellate symbionts that provide nutrients. Besides sugars, the transfer of sterols is essential for corals…”
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Stearic acid blunts growth-factor signaling via oleoylation of GNAI proteins by Nůsková, Hana, Serebryakova, Marina V., Ferrer-Caelles, Anna, Sachsenheimer, Timo, Lüchtenborg, Christian, Miller, Aubry K., Brügger, Britta, Kordyukova, Larisa V., Teleman, Aurelio A.

“…Covalent attachment of C16:0 to proteins (palmitoylation) regulates protein function. Proteins are also S-acylated by other fatty acids including C18:0…”
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Molecular and structural architecture of polyQ aggregates in yeast by Gruber, Anselm, Hornburg, Daniel, Antonin, Matthias, Krahmer, Natalie, Collado, Javier, Schaffer, Miroslava, Zubaite, Greta, Lüchtenborg, Christian, Sachsenheimer, Timo, Brügger, Britta, Mann, Matthias, Baumeister, Wolfgang, Hartl, F. Ulrich, Hipp, Mark S., Fernández-Busnadiego, Rubén

“…Huntington’s disease is caused by the expansion of a polyglutamine (polyQ) tract in the N-terminal exon of huntingtin (HttEx1), but the cellular mechanisms…”
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In Vivo Profiling and Visualization of Cellular Protein-Lipid Interactions Using Bifunctional Fatty Acids by Haberkant, Per, Raijmakers, Reinout, Wildwater, Marjolein, Sachsenheimer, Timo, Brügger, Britta, Maeda, Kenji, Houweling, Martin, Gavin, Anne-Claude, Schultz, Carsten, van Meer, Gerrit, Heck, Albert J. R., Holthuis, Joost C. M.

“…Bifunctional lipid technology: Cells convert externally added photoactivatable and “clickable” fatty acids into a variety of bifunctional phospholipids that…”
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A New, Rapid Method for the Quantification of Dolichyl Phosphates in Cell Cultures Using TMSD Methylation Combined with LC–MS Analysis by Kale, Dipali, Sachsenheimer, Timo, Sickmann, Albert, Brügger, Britta

“…Dolichyl phosphates (DolP) are ubiquitous lipids that are present in almost all eukaryotic membranes. They play a key role in several protein glycosylation…”
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PRL-3 disrupts epithelial architecture by altering the post-mitotic midbody position by Luján, Pablo, Varsano, Giulia, Rubio, Teresa, Hennrich, Marco L, Sachsenheimer, Timo, Gálvez-Santisteban, Manuel, Martín-Belmonte, Fernando, Gavin, Anne-Claude, Brügger, Britta, Köhn, Maja

“…Disruption of epithelial architecture is a fundamental event during epithelial tumorigenesis. We show that the expression of the cancer-promoting phosphatase…”
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Peroxisomal dysfunctions cause lysosomal storage and axonal Kv1 channel redistribution in peripheral neuropathy by Kleinecke, Sandra, Richert, Sarah, de Hoz, Livia, Brügger, Britta, Kungl, Theresa, Asadollahi, Ebrahim, Quintes, Susanne, Blanz, Judith, McGonigal, Rhona, Naseri, Kobra, Sereda, Michael W, Sachsenheimer, Timo, Lüchtenborg, Christian, Möbius, Wiebke, Willison, Hugh, Baes, Myriam, Nave, Klaus-Armin, Kassmann, Celia Michèle

“…Impairment of peripheral nerve function is frequent in neurometabolic diseases, but mechanistically not well understood. Here, we report a novel disease…”
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Sphingosine-1-Phosphate Lyase Deficient Cells as a Tool to Study Protein Lipid Interactions by Gerl, Mathias J, Bittl, Verena, Kirchner, Susanne, Sachsenheimer, Timo, Brunner, Hanna L, Lüchtenborg, Christian, Özbalci, Cagakan, Wiedemann, Hannah, Wegehingel, Sabine, Nickel, Walter, Haberkant, Per, Schultz, Carsten, Krüger, Marcus, Brügger, Britta

“…Cell membranes contain hundreds to thousands of individual lipid species that are of structural importance but also specifically interact with proteins. Due to…”
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Sphingomyelin organization is required for vesicle biogenesis at the Golgi complex by Duran, Juan M, Campelo, Felix, van Galen, Josse, Sachsenheimer, Timo, Sot, Jesús, Egorov, Mikhail V, Rentero, Carles, Enrich, Carlos, Polishchuk, Roman S, Goñi, Félix M, Brügger, Britta, Wieland, Felix, Malhotra, Vivek

“…Sphingomyelin and cholesterol can assemble into domains and segregate from other lipids in the membranes. These domains are reported to function as platforms…”
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Quantification of Signaling Lipids by Nano-Electrospray Ionization Tandem Mass Spectrometry (Nano-ESI MS/MS) by Haag, Mathias, Schmidt, Angelika, Sachsenheimer, Timo, Brügger, Britta

“…Lipids, such as phosphoinositides (PIPs) and diacylglycerol (DAG), are important signaling intermediates involved in cellular processes such as T cell receptor…”
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Brr6 and Brl1 locate to nuclear pore complex assembly sites to promote their biogenesis by Zhang, Wanlu, Neuner, Annett, Rüthnick, Diana, Sachsenheimer, Timo, Lüchtenborg, Christian, Brügger, Britta, Schiebel, Elmar

“…The paralogous Brr6 and Brl1 are conserved integral membrane proteins of the nuclear envelope (NE) with an unclear role in nuclear pore complex (NPC)…”
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Comparative lipidomics analysis of HIV‐1 particles and their producer cell membrane in different cell lines by Lorizate, Maier, Sachsenheimer, Timo, Glass, Bärbel, Habermann, Anja, Gerl, Mathias J., Kräusslich, Hans‐Georg, Brügger, Britta

“…Summary Human immunodeficiency virus type 1 (HIV‐1) is a retrovirus that obtains its lipid envelope by budding through the plasma membrane of infected host…”
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The UbiB family member Cqd1 forms a novel membrane contact site in mitochondria by Khosravi, Siavash, Chelius, Xenia, Unger, Ann-Katrin, Rieger, Daniela, Frickel, Johanna, Sachsenheimer, Timo, Lüchtenborg, Christian, Schieweck, Rico, Brügger, Britta, Westermann, Benedikt, Klecker, Till, Neupert, Walter, Harner, Max E

“…Mitochondria are essential organelles of eukaryotic cells and are characterized by their unique and complex membrane system. They are confined from the cytosol…”
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Competition for cysteine acylation by C16:0 and C18:0 derived lipids is a global phenomenon in the proteome by Nůsková, Hana, Cortizo, Fabiola Garcia, Schwenker, Lena Sophie, Sachsenheimer, Timo, Diakonov, Egor E., Tiebe, Marcel, Schneider, Martin, Lohbeck, Jasmin, Reid, Carissa, Kopp-Schneider, Annette, Helm, Dominic, Brügger, Britta, Miller, Aubry K., Teleman, Aurelio A.

“…S-acylation is a reversible posttranslational protein modification consisting of attachment of a fatty acid to a cysteine via a thioester bond. Research over…”
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Critical Role for Ceramide Synthase 2 in Liver Homeostasis: I. ALTERATIONS IN LIPID METABOLIC PATHWAYS by Pewzner-Jung, Yael, Park, Hyejung, Laviad, Elad L, Silva, Liana C, Lahiri, Sujoy, Stiban, Johnny, Erez-Roman, Racheli, Brügger, Britta, Sachsenheimer, Timo, Wieland, Felix, Prieto, Manuel, Merrill, Alfred H. Jr, Futerman, Anthony H

“…Ceramide is an important lipid signaling molecule that plays critical roles in regulating cell behavior. Ceramide synthesis is surprisingly complex and is…”
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InVivo Profiling and Visualization of Cellular Protein-Lipid Interactions Using Bifunctional Fatty Acids by Haberkant, Per, Raijmakers, Reinout, Wildwater, Marjolein, Sachsenheimer, Timo, Brügger, Britta, Maeda, Kenji, Houweling, Martin, Gavin, Anne-Claude, Schultz, Carsten, vanMeer, Gerrit, Heck, Albert J. R, Holthuis, Joost C. M

“…Bifunctional lipid technology: Cells convert externally added photoactivatable and "clickable" fatty acids into a variety of bifunctional phospholipids that…”
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Phospholipidation of nuclear proteins by the human papillomavirus E6 oncoprotein: implication in carcinogenesis by Marx, Benjamin, Hufbauer, Martin, Zigrino, Paola, Majewski, Slawomir, Markiefka, Birgid, Sachsenheimer, Timo, Brügger, Britta, Akgül, Baki

“…Phospholipids regulate numerous cellular functions and their deregulation is known to be associated with cancer development. Here, we show for the first time…”
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A Global Circadian Repressor Controls Antiphasic Expression of Metabolic Genes in Neurospora by Sancar, Gencer, Sancar, Cigdem, Brügger, Britta, Ha, Nati, Sachsenheimer, Timo, Gin, Elan, Wdowik, Simon, Lohmann, Ingrid, Wieland, Felix, Höfer, Thomas, Diernfellner, Axel, Brunner, Michael

“…The white-collar complex (WCC), the core transcription factor of the circadian clock of Neurospora, activates morning-specific expression of the transcription…”
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Poxvirus membrane biogenesis: rupture not disruption by Krijnse Locker, Jacomine, Chlanda, Petr, Sachsenheimer, Timo, Brügger, Britta

“…Summary Enveloped viruses acquire their membrane from the host by budding at, or wrapping by, cellular membranes. Transmission electron microscopy (TEM)…”
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