Changes in magnetic resonance mammography due to hormone replacement therapy

The aim of the present article is to investigate effects of hormone replacement therapy (HRT) on contrast medium enhancement patterns in postmenopausal patients during magnetic resonance mammography (MRM). Two hundred and fifteen patients receiving hormonal medication were divided into four groups:...

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Published in:	Breast cancer research : BCR Vol. 6; no. 3; pp. R232 - R238
Main Authors:	Pfleiderer, Stefan O R, Sachse, Steffen, Sauner, Dieter, Marx, Christiane, Malich, Ansgar, Wurdinger, Susanne, Kaiser, Werner A
Format:	Journal Article
Language:	English
Published:	England BioMed Central Ltd 01-01-2004 National Library of Medicine - MEDLINE Abstracts BioMed Central
Subjects:	Adipose Tissue - drug effects Adult Breast - anatomy & histology Breast - drug effects Care and treatment Connective Tissue - drug effects Contrast Media Female Follow-Up Studies Hormone Replacement Therapy Hormone therapy Humans Magnetic Resonance Imaging Middle Aged Postmenopausal women Postmenopause Retrospective Studies Withholding Treatment
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Summary:	The aim of the present article is to investigate effects of hormone replacement therapy (HRT) on contrast medium enhancement patterns in postmenopausal patients during magnetic resonance mammography (MRM). Two hundred and fifteen patients receiving hormonal medication were divided into four groups: 150 patients with 1 MRM during HRT (group A), 13 patients with 2 MRMs under HRT (group B), 30 patients with 1 MRM during HRT and 1 MRM after HRT withdrawal (group C), and 22 women with 1 MRM after HRT withdrawal (group D). Dynamic MRM was performed at 1.5 Tesla. Signal intensity changes were characterized by five time curves: minimal enhancement (type I), weak continuous enhancement (type II), strong continuous enhancement (type III), and a steep initial slope followed by a plateau phenomenon (type IV) or a washout effect (type V). Of all 193 patients under HRT (group A + group B + group C), 60 patients (31.1%) showed curve type I, 88 patients (45.6%) showed type II and 45 patients (23.3%) showed type III. There were significant differences to 52 patients after HRT withdrawal (group C + group D) (P < 0.0001), with 42 patients (80.8%) for curve type I, 8 patients (15.4%) for type II, and 2 patients (3.8%) for type III. In both MRM sessions in group B, 69% of the patients showed identical curve types without significant differences (P = 0.375). In group C, 28 of 30 patients (93%) dropped to lower curve types with significant differences in curve types during and after HRT (P < 0.0001). The majority of patients receiving postmenopausal HRT showed bilateral symmetrical, continuous enhancement without evidence of a plateau phenomenon or a washout effect due to HRT in MRM. Hormonal effects could be proven and were reproducible and reversible.
Bibliography:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23
ISSN:	1465-542X 1465-5411 1465-542X
DOI:	10.1186/bcr779