Search Results - "Sachs, Ulrich J. H."

The pathogenesis of transfusion‐related acute lung injury (TRALI) by Bux, Jürgen, Sachs, Ulrich J. H.

“…Summary In recent years, transfusion‐related acute lung injury (TRALI) has developed from an almost unknown transfusion reaction to the most common cause of…”
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Mechanism of transfusion-related acute lung injury induced by HLA class II antibodies by Sachs, Ulrich J.H., Wasel, Wiebke, Bayat, Behnaz, Bohle, Rainer M., Hattar, Katja, Berghöfer, Heike, Reil, Angelika, Bux, Jürgen, Bein, Gregor, Santoso, Sentot, Weissmann, Norbert

“…Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the United States and other countries. In most TRALI…”
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In Vivo Thrombus Formation in Murine Models by Sachs, Ulrich J.H, Nieswandt, Bernhard

“…Platelets play a central role in hemostasis, but also in atherothrombosis, as they rapidly adhere to tissue and to one another as a response to any vascular…”
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Antibody-induced neutrophil activation as a trigger for transfusion-related acute lung injury in an ex vivo rat lung model by Sachs, Ulrich J.H., Hattar, Katja, Weissmann, Norbert, Bohle, Rainer M., Weiss, Timo, Sibelius, Ulf, Bux, Juergen

“…Transfusion-related acute lung injury (TRALI) is a hazardous complication of transfusion and has become the leading cause of transfusion-related death in the…”
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The Neutrophil-specific Antigen CD177 Is a Counter-receptor for Platelet Endothelial Cell Adhesion Molecule-1 (CD31) by Sachs, Ulrich J.H., Andrei-Selmer, Cornelia L., Maniar, Amudhan, Weiss, Timo, Paddock, Cathy, Orlova, Valeria V., Choi, Eun Young, Newman, Peter J., Preissner, Klaus T., Chavakis, Triantafyllos, Santoso, Sentot

“…Human neutrophil-specific CD177 (NB1 and PRV-1) has been reported to be up-regulated in a number of inflammatory settings, including bacterial infection and…”
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A novel enzyme-linked immunosorbent assay method for the detection of human neutrophil antigen-2a antibodies by Bayat, Behnaz, Werth, Silke, Sachs, Ulrich J. H., Santoso, Sentot

“…BACKGROUND: Antibodies to human neutrophil antigen (HNA)‐2a are responsible for a number of immune‐mediated neutropenia disorders. Although several methods…”
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Neutrophil Transmigration Mediated by the Neutrophil-Specific Antigen CD177 Is Influenced by the Endothelial S536N Dimorphism of Platelet Endothelial Cell Adhesion Molecule-1 by Bayat, Behnaz, Werth, Silke, Sachs, Ulrich J. H, Newman, Debra K, Newman, Peter J, Santoso, Sentot

“…The human neutrophil-specific adhesion molecule CD177 (also known as the NB1 alloantigen) becomes upregulated on the cell surface in a number of inflammatory…”
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Rapid detection of HPA-1 alloantibodies by platelet antigens immobilized onto microbeads by Bakchoul, Tamam, Meyer, Oliver, Agaylan, Ashraf, Bombard, Stephane, Bein, Gregor, Sachs, Ulrich J.H., Salama, Abdulgabar, Santoso, Sentot

“…BACKGROUND: Neonatal alloimmune thrombocytopenia (NAIT) is one of the most common bleeding disorders in neonates. It occurs when alloantibodies from an…”
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Performance characteristics of two commercially available IgG-specific immunoassays in the assessment of heparin-induced thrombocytopenia (HIT) by Bakchoul, Tamam, Giptner, Astrid, Bein, Gregor, Santoso, Sentot, Sachs, Ulrich J.H

“…Abstract Background The in vitro demonstration of antibodies against platelet factor-4/heparin (PF4/hep) complexes is an important contribution to the…”
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Bernard–Soulier syndrome due to the homozygous Asn‐45Ser mutation in GPIX: an unexpected, frequent finding in Germany by Sachs, Ulrich J. H., Kroll, Hartmut, Matzdorff, Axel C., Berghöfer, Heike, Löpez, José A., Santoso, Sentot

“…Bernard–Soulier syndrome (BSS) is a rare inherited disorder with giant platelets, thrombocytopenia and a prolonged bleeding time. These abnormalities are…”
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Safety and efficacy of therapeutic early onset granulocyte transfusions in pediatric patients with neutropenia and severe infections by Sachs, Ulrich J.H., Reiter, Alfred, Walter, Tobias, Bein, Gregor, Woessmann, Wilhelm

“…BACKGROUND: Bacterial and fungal infections in profound neutropenia after chemotherapy are associated with high mortality despite appropriate antibacterial and…”
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Reduced thrombus stability in mice lacking the α2A-adrenergic receptor by Požgajová, Miroslava, Sachs, Ulrich J.H., Hein, Lutz, Nieswandt, Bernhard

“…Platelet activation plays a central role in hemostasis and thrombosis. Many platelet agonists function through G-protein–coupled receptors. Epinephrine…”
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Frequency of heparin/platelet factor 4-dependent platelet antibodies in patients undergoing angioplasty and stenting for cardiovascular disease and their role for on-clopidogrel platelet reactivity by Gremmel, Thomas, Frühwirth, Karin, Kopp, Christoph W., Kaider, Alexandra, Steiner, Sabine, Bakchoul, Tamam, Sachs, Ulrich J. H., Koppensteiner, Renate, Panzer, Simon

“…Background The frequency of heparin-induced platelet antibodies (H/PF4 antibodies) following heparin exposure during percutaneous intervention with stent…”
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Human alloantibody anti-Mart interferes with Mac-1–dependent leukocyte adhesion by Sachs, Ulrich J.H., Chavakis, Triantafyllos, Fung, Lin, Lohrenz, Alexander, Bux, Jürgen, Reil, Angelika, Ruf, Andreas, Santoso, Sentot

“…The CD11b/CD18 integrin plays a crucial role in cell-cell adhesion processes. Recently, we described a case of severe neonatal alloimmune neutropenia (NAIN)…”
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Transfusion-Associated Graft-Versus-Host Disease by Rühl, Heiko, Bein, Gregor, Sachs, Ulrich J.H

“…Transfusion-associated graft-versus-host disease (TA-GvHD) is a rare complication of blood transfusion that has a fatal outcome in most patients. It is caused…”
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A variable number of tandem repeats polymorphism influences the transcriptional activity of the neonatal Fc receptor α‐chain promoter by Sachs, Ulrich J. H., Socher, Ines, Braeunlich, Christian G., Kroll, Hartmut, Bein, Gregor, Santoso, Sentot

“…Summary The neonatal Fc receptor, FcRn, plays a central role in immunoglobulin G (IgG) transport across placental barriers. Genetic variations of…”
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White blood cell-reactive antibodies are undetectable in solvent/detergent plasma by Sachs, Ulrich J.H., Kauschat, Dörte, Bein, Gregor

“…BACKGROUND: Transfusion‐related acute lung injury (TRALI) is a life‐threatening complication of transfusion. Although all types of blood products have been…”
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Blockade of maternal anti-HPA-1a-mediated platelet clearance by an HPA-1a epitope-specific F(ab') in an in vivo mouse model of alloimmune thrombocytopenia by Bakchoul, Tamam, Boylan, Brian, Sachs, Ulrich J H, Bein, Gregor, Ruan, Changgeng, Santoso, Sentot, Newman, Peter J

“…Neonatal alloimmune thrombocytopenia (NAIT) is most commonly caused by transplacental passage of maternal human platelet-specific alloantigen (HPA)-1a…”
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Pulmonary Transfusion Reactions by Bux, Jürgen, Sachs, Ulrich J.H.

“…Background: In recent years, pulmonary transfusion reactions have gained increasing importance as serious adverse transfusion events. Methods: Review of the…”
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Does a negative direct antiglobulin test exclude warm autoimmune haemolytic anaemia? A prospective study of 504 cases by Sachs, Ulrich J. H., Röder, Lida, Santoso, Sentot, Bein, Gregor

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