Search Results - "Sachs, Ulrich"

The pathogenesis of transfusion‐related acute lung injury (TRALI) by Bux, Jürgen, Sachs, Ulrich J. H.

“…Summary In recent years, transfusion‐related acute lung injury (TRALI) has developed from an almost unknown transfusion reaction to the most common cause of…”
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Prothrombotic immune thrombocytopenia after COVID-19 vaccination by Tiede, Andreas, Sachs, Ulrich J., Czwalinna, Andreas, Werwitzke, Sonja, Bikker, Rolf, Krauss, Joachim K., Donnerstag, Frank, Weißenborn, Karin, Höglinger, Günter, Maasoumy, Benjamin, Wedemeyer, Heiner, Ganser, Arnold

“…We report 5 cases of prothrombotic immune thrombocytopenia after exposure to the ChAdOx1 vaccine (AZD1222, Vaxzevria) against severe acute respiratory syndrome…”
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Recommendations for the clinical and laboratory diagnosis of VITT against COVID‐19: Communication from the ISTH SSC Subcommittee on Platelet Immunology by Nazy, Ishac, Sachs, Ulrich J., Arnold, Donald M., McKenzie, Steven E., Choi, Phil, Althaus, Karina, Ahlen, Maria Therese, Sharma, Ruchika, Grace, Rachael F., Bakchoul, Tamam

“…Vaccine administration is under way worldwide to combat the current COVID‐19 pandemic. The newly developed vaccines are highly effective with minimal adverse…”
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In Vivo Thrombus Formation in Murine Models by Sachs, Ulrich J.H, Nieswandt, Bernhard

“…Platelets play a central role in hemostasis, but also in atherothrombosis, as they rapidly adhere to tissue and to one another as a response to any vascular…”
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Pitfalls in Coagulation Testing by Sachs, Ulrich J

“…Assays in the coagulation laboratory are affected by numerous variables. Variables which have impact on the test result can lead to incorrect results, and…”
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Recombinantly Expressed Tagged SUrface Protein (RETSUP) assay: a new diagnostic system for the detection of antibodies to platelets by Weber, Susanne, Arnold, Jasmin Birgit Zuzana, Sachs, Ulrich Jörg, Luppa, Peter Bruno

“…Current assays for the detection of (allo)antibodies to platelet antigens are often laborious and widely based on the presence of well-characterized donor…”
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Prospects for risk stratification of anti-HPA-1a alloimmunized pregnant women by Sachs, Ulrich J.

“…A diagnosis of fetal/neonatal alloimmune thrombocytopenia (FNAIT) is made if a platelet-specific antibody is detected in the mother and the fetus or newborn…”
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PF4-Dependent Immunoassays in Patients with Vaccine-Induced Immune Thrombotic Thrombocytopenia: Results of an Interlaboratory Comparison by Sachs, Ulrich J, Cooper, Nina, Czwalinna, Andreas, Müller, Jens, Pötzsch, Bernd, Tiede, Andreas, Althaus, Karina

“…Coronavirus disease 2019 vaccine ChAdOx1 nCov-19 may rarely lead to vaccine-induced thrombotic thrombocytopenia (VITT). Antibody-mediated, platelet factor 4…”
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Antibody-mediated procoagulant platelets in SARS-CoV-2- vaccination associated immune thrombotic thrombocytopenia by Althaus, Karina, Möller, Peter, Uzun, Günalp, Singh, Anurag, Beck, Annika, Bettag, Martin, Bösmüller, Hans, Guthoff, Martina, Dorn, Franziska, Petzold, Gabor C, Henkes, Hans, Heyne, Nils, Jumaa, Hassan, Kreiser, Kornelia, Limpach, Caroline, Luz, Beate, Maschke, Matthias, Müller, Janis A, Münch, Jan, Nagel, Simon, Pötzsch, Bernd, Müller, Jens, Schlegel, Christoph, Viardot, Andreas, Bäzner, Hansjörg, Wolf, Marc, Pelzl, Lisann, Warm, Verena, Willinek, Winfried A, Steiner, Jochen, Schneiderhan-Marra, Nicole, Vollherbst, Dominik, Sachs, Ulrich J, Fend, Falko, Bakchoul, Tamam

“…The COVID-19 pandemic has resulted in significant morbidity and mortality worldwide. To prevent severe infection, mass COVID-19 vaccination campaigns with…”
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Diagnosing Immune Thrombocytopenia by Sachs, Ulrich J

“…Although the detection of a characteristic autoantibody can prove immune thrombocytopenia (ITP), this diagnosis is often based on the exclusion of other causes…”
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The Neutrophil-specific Antigen CD177 Is a Counter-receptor for Platelet Endothelial Cell Adhesion Molecule-1 (CD31) by Sachs, Ulrich J.H., Andrei-Selmer, Cornelia L., Maniar, Amudhan, Weiss, Timo, Paddock, Cathy, Orlova, Valeria V., Choi, Eun Young, Newman, Peter J., Preissner, Klaus T., Chavakis, Triantafyllos, Santoso, Sentot

“…Human neutrophil-specific CD177 (NB1 and PRV-1) has been reported to be up-regulated in a number of inflammatory settings, including bacterial infection and…”
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Anti‐human neutrophil antigen‐1d specificity is frequently observed in anti‐human neutrophil antigen‐1b alloantisera by Grabowski, Claudia, Reil, Angelika, Bux, Jürgen, Bayat, Behnaz, Sachs, Ulrich J.

“…Background Four amino acids are involved in epitope formation of human neutrophil antigens (HNA)‐1 alleles, located at positions 36, 65, 78, and 82. HNA‐1a and…”
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Anti‐human platelet antigen‐5b antibodies and fetal and neonatal alloimmune thrombocytopenia; incidental association or cause and effect? by Alm, Julia, Duong, Yalin, Wienzek‐Lischka, Sandra, Cooper, Nina, Santoso, Sentot, Sachs, Ulrich J., Kiefel, Volker, Bein, Gregor

“…Summary Most cases of fetal and neonatal thrombocytopenia (FNAIT) are caused by maternal anti‐human platelet antigen‐1a antibodies (anti‐HPA‐1a). Anti‐HPA‐5b…”
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Be alert to leukocyte antibodies when prescribing granulocyte transfusions by Bux, Juergen, Sachs, Ulrich J.

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Laboratory Testing: Current Aspects by Müller, Jens, Sachs, Ulrich J

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A sequence-specific polymerase chain reaction method for HNA-2 genotyping: homozygous c.843A>T mutation predicts the absence of CD177 by Bayat, Behnaz, Bein, Gregor, Sachs, Ulrich J.

“…BACKGROUND Human neutrophil antigen‐2 is located on a glycosylphosphatidylinositol‐anchored receptor, CD177. Humans not expressing CD177 on their neutrophils…”
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Antiendothelial αvβ3 Antibodies Are a Major Cause of Intracranial Bleeding in Fetal/Neonatal Alloimmune Thrombocytopenia by Santoso, Sentot, Wihadmadyatami, Hevi, Bakchoul, Tamam, Werth, Silke, Al-Fakhri, Nadia, Bein, Gregor, Kiefel, Volker, Zhu, Jieqing, Newman, Peter J, Bayat, Behnaz, Sachs, Ulrich J

“…OBJECTIVE—Fetal/neonatal alloimmune thrombocytopenia is a severe bleeding disorder, which can result in intracranial hemorrhage (ICH), leading to death or…”
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Piperacillin‐dependent anti‐platelet antibodies are a relevant, easy to confirm differential diagnosis in patients with rapid‐onset thrombocytopenia by Chen, Shu, Cooper, Nina, Müller, Marica, Bein, Gregor, Sachs, Ulrich J.

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Characterization of CD177‐reactive iso‐ and auto‐antibodies by Traum, Annalena, Hofmann, Christine, Haas, Sabine, Schmidt, Silke, Bein, Gregor, Sachs, Ulrich J., Bayat, Behnaz

“…Background CD177 is a surface protein on neutrophils and a main mediator for the surface expression of proteinase 3 (PR3). Its functions are largely unknown…”
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Mechanism of transfusion-related acute lung injury induced by HLA class II antibodies by Sachs, Ulrich J.H., Wasel, Wiebke, Bayat, Behnaz, Bohle, Rainer M., Hattar, Katja, Berghöfer, Heike, Reil, Angelika, Bux, Jürgen, Bein, Gregor, Santoso, Sentot, Weissmann, Norbert

“…Transfusion-related acute lung injury (TRALI) is the leading cause of transfusion-associated mortality in the United States and other countries. In most TRALI…”
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