Search Results - "Sachs, Stephan"

Glucagon Regulation of Energy Expenditure by Kleinert, Maximilian, Sachs, Stephan, Habegger, Kirk M, Hofmann, Susanna M, Müller, Timo D

“…Glucagon's ability to increase energy expenditure has been known for more than 60 years, yet the mechanisms underlining glucagon's thermogenic effect still…”
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Plasma proteome profiling discovers novel proteins associated with non‐alcoholic fatty liver disease by Niu, Lili, Geyer, Philipp E, Wewer Albrechtsen, Nicolai J, Gluud, Lise L, Santos, Alberto, Doll, Sophia, Treit, Peter V, Holst, Jens J, Knop, Filip K, Vilsbøll, Tina, Junker, Anders, Sachs, Stephan, Stemmer, Kerstin, Müller, Timo D, Tschöp, Matthias H, Hofmann, Susanna M, Mann, Matthias

“…Non‐alcoholic fatty liver disease (NAFLD) affects 25% of the population and can progress to cirrhosis with limited treatment options. As the liver secretes…”
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Intermuscular adipose tissue directly modulates skeletal muscle insulin sensitivity in humans by Sachs, Stephan, Zarini, Simona, Kahn, Darcy E, Harrison, Kathleen A, Perreault, Leigh, Phang, Tzu, Newsom, Sean A, Strauss, Allison, Kerege, Anna, Schoen, Jonathan A, Bessesen, Daniel H, Schwarzmayr, Thomas, Graf, Elisabeth, Lutter, Dominik, Krumsiek, Jan, Hofmann, Susanna M, Bergman, Bryan C

“…Intermuscular adipose tissue (IMAT) is negatively related to insulin sensitivity, but a causal role of IMAT in the development of insulin resistance is…”
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Monomeric GLP-1/GIP/glucagon triagonism corrects obesity, hepatosteatosis, and dyslipidemia in female mice by Jall, Sigrid, Sachs, Stephan, Clemmensen, Christoffer, Finan, Brian, Neff, Frauke, DiMarchi, Richard D, Tschöp, Matthias H, Müller, Timo D, Hofmann, Susanna M

“…Abstract Objective Obesity is a major health threat that affects men and women equally. Despite this fact, weight-loss potential of pharmacotherapies is…”
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Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes by Clemmensen, Christoffer, Jall, Sigrid, Kleinert, Maximilian, Quarta, Carmelo, Gruber, Tim, Reber, Josefine, Sachs, Stephan, Fischer, Katrin, Feuchtinger, Annette, Karlas, Angelos, Simonds, Stephanie E., Grandl, Gerald, Loher, Daniela, Sanchez-Quant, Eva, Keipert, Susanne, Jastroch, Martin, Hofmann, Susanna M., Nascimento, Emmani B. M., Schrauwen, Patrick, Ntziachristos, Vasilis, Cowley, Michael A., Finan, Brian, Müller, Timo D., Tschöp, Matthias H.

“…Pharmacological stimulation of brown adipose tissue (BAT) thermogenesis to increase energy expenditure is progressively being pursued as a viable anti-obesity…”
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Correction: GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease by Sachs, Stephan, Götz, Anna, Finan, Brian, Feuchtinger, Annette, DiMarchi, Richard D, Döring, Yvonne, Weber, Christian, Tschöp, Matthias H, Müller, Timo D, Hofmann, Susanna M

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GIP receptor agonism improves dyslipidemia and atherosclerosis independently of body weight loss in preclinical mouse model for cardio-metabolic disease by Sachs, Stephan, Götz, Anna, Finan, Brian, Feuchtinger, Annette, DiMarchi, Richard D, Döring, Yvonne, Weber, Christian, Tschöp, Matthias H, Müller, Timo D, Hofmann, Susanna M

“…Agonism at the receptor for the glucose-dependent insulinotropic polypeptide (GIPR) is a key component of the novel unimolecular GIPR:GLP-1R co-agonists, which…”
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Circulating HDL levels control hypothalamic astrogliosis via apoA-I by Götz, Anna, Lehti, Maarit, Donelan, Elizabeth, Striese, Cynthia, Cucuruz, Sebastian, Sachs, Stephan, Yi, Chun-Xia, Woods, Stephen C., Wright, Samuel D., Müller, Timo D., Tschöp, Matthias H., Gao, Yuanqing, Hofmann, Susanna M.

“…Meta-inflammation of hypothalamic areas governing energy homeostasis has recently emerged as a process of potential pathophysiological relevance for the…”
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A point mutation in the Pdia6 gene results in loss of pancreatic β-cell identity causing overt diabetes by Chhabra, Nirav Florian, Amend, Anna–Lena, Bastidas-Ponce, Aimée, Sabrautzki, Sibylle, Tarquis-Medina, Marta, Sachs, Stephan, Rubey, Marina, Lorenz-Depiereux, Bettina, Feuchtinger, Annette, Bakhti, Mostafa, Lickert, Heiko, Przemeck, Gerhard K.H., Hrabě de Angelis, Martin

“…Protein disulfide isomerases (PDIs) are oxidoreductases that are involved in catalyzing the formation and rearrangement of disulfide bonds during protein…”
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Activated macrophages control human adipocyte mitochondrial bioenergetics via secreted factors by Keuper, Michaela, Sachs, Stephan, Walheim, Ellen, Berti, Lucia, Raedle, Bernhard, Tews, Daniel, Fischer-Posovszky, Pamela, Wabitsch, Martin, Hrabě de Angelis, Martin, Kastenmüller, Gabi, Tschöp, Matthias H., Jastroch, Martin, Staiger, Harald, Hofmann, Susanna M.

“…Obesity-associated WAT inflammation is characterized by the accumulation and local activation of macrophages (MΦs), and recent data from mouse studies suggest…”
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Preadipocytes of obese humans display gender-specific bioenergetic responses to glucose and insulin by Keuper, Michaela, Berti, Lucia, Raedle, Bernhard, Sachs, Stephan, Böhm, Anja, Fritsche, Louise, Fritsche, Andreas, Häring, Hans-Ulrich, Hrabě de Angelis, Martin, Jastroch, Martin, Hofmann, Susanna M., Staiger, Harald

“…Although the prevalence of obesity and its associated metabolic disorders is increasing in both sexes, the clinical phenotype differs between men and women,…”
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Publisher Correction: Coordinated targeting of cold and nicotinic receptors synergistically improves obesity and type 2 diabetes by Clemmensen, Christoffer, Jall, Sigrid, Kleinert, Maximilian, Quarta, Carmelo, Gruber, Tim, Reber, Josefine, Sachs, Stephan, Fischer, Katrin, Feuchtinger, Annette, Karlas, Angelos, Simonds, Stephanie E., Grandl, Gerald, Loher, Daniela, Sanchez-Quant, Eva, Keipert, Susanne, Jastroch, Martin, Hofmann, Susanna M., Nascimento, Emmani B. M., Schrauwen, Patrick, Ntziachristos, Vasilis, Cowley, Michael A., Finan, Brian, Müller, Timo D., Tschöp, Matthias H.

“…In the original PDF version of this article, affiliation 1, ‘Institute for Diabetes and Obesity, Helmholtz Diabetes Center (HDC), Helmholtz Zentrum Muenchen &…”
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Pharmacological Targeting of Endoplasmic Reticulum Stress in Pancreatic Beta Cells by Bilekova, Sara, Sachs, Stephan, Lickert, Heiko

“…Diabetes is a disease with pandemic dimensions and no pharmacological treatment prevents disease progression. Dedifferentiation has been proposed to be a…”
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Skeletal muscle and intermuscular adipose tissue gene expression profiling identifies new biomarkers with prognostic significance for insulin resistance progression and intervention response by Lutter, Dominik, Sachs, Stephan, Walter, Marc, Kerege, Anna, Perreault, Leigh, Kahn, Darcy E., Wolide, Amare D., Kleinert, Maximilian, Bergman, Bryan C., Hofmann, Susanna M.

“…Aims/hypothesis Although insulin resistance often leads to type 2 diabetes mellitus, its early stages are often unrecognised, thus reducing the probability of…”
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Targeted pharmacological therapy restores β-cell function for diabetes remission by Sachs, Stephan, Bastidas-Ponce, Aimée, Tritschler, Sophie, Bakhti, Mostafa, Böttcher, Anika, Sánchez-Garrido, Miguel A., Tarquis-Medina, Marta, Kleinert, Maximilian, Fischer, Katrin, Jall, Sigrid, Harger, Alexandra, Bader, Erik, Roscioni, Sara, Ussar, Siegfried, Feuchtinger, Annette, Yesildag, Burcak, Neelakandhan, Aparna, Jensen, Christine B., Cornu, Marion, Yang, Bin, Finan, Brian, DiMarchi, Richard D., Tschöp, Matthias H., Theis, Fabian J., Hofmann, Susanna M., Müller, Timo D., Lickert, Heiko

“…Dedifferentiation of insulin-secreting β cells in the islets of Langerhans has been proposed to be a major mechanism of β-cell dysfunction. Whether…”
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Plasma proteome profiles treatment efficacy of incretin dual agonism in diet‐induced obese female and male mice by Sachs, Stephan, Niu, Lili, Geyer, Philipp, Jall, Sigrid, Kleinert, Maximilian, Feuchtinger, Annette, Stemmer, Kerstin, Brielmeier, Markus, Finan, Brian, DiMarchi, Richard D., Tschöp, Matthias H., Wewer Albrechtsen, Nicolai, Mann, Matthias, Müller, Timo D., Hofmann, Susanna M.

“…Aims Unimolecular peptides targeting the receptors for glucagon‐like peptide‐1 (GLP‐1) and glucose‐dependent insulinotropic polypeptide (GIP) (GLP‐1/GIP…”
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Pharmacological targeting of α3β4 nicotinic receptors improves peripheral insulin sensitivity in mice with diet-induced obesity by Jall, Sigrid, De Angelis, Meri, Lundsgaard, Anne-Marie, Fritzen, Andreas M., Nicolaisen, Trine S., Klein, Anders B., Novikoff, Aaron, Sachs, Stephan, Richter, Erik A., Kiens, Bente, Schramm, Karl-Werner, Tschöp, Matthias H., Stemmer, Kerstin, Clemmensen, Christoffer, Müller, Timo D., Kleinert, Maximilian

“…Aims/hypothesis Treatment with the α3β4 nicotinic acetylcholine receptor (nAChR) agonist, 1,1-dimethyl-4-phenylpiperazinium iodide (DMPP), improves glucose…”
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936-P: Plasma Proteomic Profiling Delineates Treatment Efficacy of a GLP-1/GIP Coagonist in Female and Male Mice by HOFMANN, SUSANNA M., WEWER ALBRECHTSEN, NICOLAI J., TSCHÖP, MATTHIAS H., FEUCHTINGER, ANNETTE, BRIELMEIER, MARKUS, FINAN, BRIAN, DIMARCHI, RICHARD, KLEINERT, MAXIMILIAN, SACHS, STEPHAN, MÜLLER, TIMO D., STEMMER, KERSTIN, MANN, MATTHIAS

“…Objective: Polypharmacotherapy shows superior efficacy compared to monotherapy in correcting obesity and its co-morbidities in preclinical studies and clinical…”
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Author Correction: Targeted pharmacological therapy restores β-cell function for diabetes remission by Sachs, Stephan, Bastidas-Ponce, Aimée, Tritschler, Sophie, Bakhti, Mostafa, Böttcher, Anika, Sánchez-Garrido, Miguel A., Tarquis-Medina, Marta, Kleinert, Maximilian, Fischer, Katrin, Jall, Sigrid, Harger, Alexandra, Bader, Erik, Roscioni, Sara, Ussar, Siegfried, Feuchtinger, Annette, Yesildag, Burcak, Neelakandhan, Aparna, Jensen, Christine B., Cornu, Marion, Yang, Bin, Finan, Brian, DiMarchi, Richard D., Tschöp, Matthias H., Theis, Fabian J., Hofmann, Susanna M., Müller, Timo D., Lickert, Heiko

“…An amendment to this paper has been published and can be accessed via a link at the top of the paper…”
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