Search Results - "Sachs, Matthew S"

Codon Usage Influences the Local Rate of Translation Elongation to Regulate Co-translational Protein Folding by Yu, Chien-Hung, Dang, Yunkun, Zhou, Zhipeng, Wu, Cheng, Zhao, Fangzhou, Sachs, Matthew S., Liu, Yi

“…Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and has been proposed to regulate translation efficiency, accuracy, and protein…”
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Non-optimal codon usage affects expression, structure and function of clock protein FRQ by Zhou, Mian, Guo, Jinhu, Cha, Joonseok, Chae, Michael, Chen, She, Barral, Jose M., Sachs, Matthew S., Liu, Yi

“…The frq gene, essential for circadian clock function, is shown to differ from most other genes in Neurospora by exhibiting non-optimal codon usage; by…”
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The Antidepressant Sertraline Provides a Promising Therapeutic Option for Neurotropic Cryptococcal Infections by Zhai, Bing, Wu, Cheng, Wang, Linqi, Sachs, Matthew S, Lin, Xiaorong

“…Classifications Services AAC Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley Reddit…”
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Control of mRNA Stability in Fungi by NMD, EJC and CBC Factors Through 3′UTR Introns by Zhang, Ying, Sachs, Matthew S

“…Abstract In higher eukaryotes the accelerated degradation of mRNAs harboring premature termination codons is controlled by nonsense-mediated mRNA decay (NMD),…”
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eRF1 mediates codon usage effects on mRNA translation efficiency through premature termination at rare codons by Yang, Qian, Yu, Chien-Hung, Zhao, Fangzhou, Dang, Yunkun, Wu, Cheng, Xie, Pancheng, Sachs, Matthew S, Liu, Yi

“…Codon usage bias is a universal feature of eukaryotic and prokaryotic genomes and plays an important role in regulating gene expression levels. A major role of…”
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Ribosome Reinitiation Directs Gene-specific Translation and Regulates the Integrated Stress Response by Young, Sara K., Willy, Jeffrey A., Wu, Cheng, Sachs, Matthew S., Wek, Ronald C.

“…In the integrated stress response, phosphorylation of eIF2α (eIF2α-P) reduces protein synthesis to conserve resources and facilitate preferential translation…”
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Ribosome Elongation Stall Directs Gene-specific Translation in the Integrated Stress Response by Young, Sara K., Palam, Lakshmi Reddy, Wu, Cheng, Sachs, Matthew S., Wek, Ronald C.

“…Upon exposure to environmental stress, phosphorylation of the α subunit of eIF2 (eIF2α-P) represses global protein synthesis, coincident with preferential…”
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Stringency of start codon selection modulates autoregulation of translation initiation factor eIF5 by Loughran, Gary, Sachs, Matthew S, Atkins, John F, Ivanov, Ivaylo P

“…An AUG in an optimal nucleotide context is the preferred translation initiation site in eukaryotic cells. Interactions among translation initiation factors,…”
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Initiation context modulates autoregulation of eukaryotic translation initiation factor 1 (eIF1) by Ivanov, Ivaylo P., Loughran, Gary, Sachs, Matthew S., Atkins, John F., Weissman, Jonathan S.

“…The central feature of standard eukaryotic translation initiation is small ribosome subunit loading at the 5' cap followed by its 5' to 3' scanning for a start…”
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Structural basis for the tryptophan sensitivity of TnaC-mediated ribosome stalling by van der Stel, Anne-Xander, Gordon, Emily R., Sengupta, Arnab, Martínez, Allyson K., Klepacki, Dorota, Perry, Thomas N., Herrero del Valle, Alba, Vázquez-Laslop, Nora, Sachs, Matthew S., Cruz-Vera, Luis R., Innis, C. Axel

“…Free L-tryptophan (L-Trp) stalls ribosomes engaged in the synthesis of TnaC, a leader peptide controlling the expression of the Escherichia coli tryptophanase…”
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The Arginine Attenuator Peptide Interferes with the Ribosome Peptidyl Transferase Center by Wei, Jiajie, Wu, Cheng, Sachs, Matthew S.

“…Article Usage Stats Services MCB Citing Articles Google Scholar PubMed Related Content Social Bookmarking CiteULike Delicious Digg Facebook Google+ Mendeley…”
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The Stringency of Start Codon Selection in the Filamentous Fungus Neurospora crassa by Wei, Jiajie, Zhang, Ying, Ivanov, Ivaylo P., Sachs, Matthew S.

“…In eukaryotic cells initiation may occur from near-cognate codons that differ from AUG by a single nucleotide. The stringency of start codon selection impacts…”
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Preparation of a Saccharomyces cerevisiae cell-free extract for in vitro translation by Wu, Cheng, Sachs, Matthew S

“…Eukaryotic cell-free in vitro translation systems have been in use since the 1970s. These systems can faithfully synthesize polypeptides when programmed with…”
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Reconstruction and validation of a genome-scale metabolic model for the filamentous fungus Neurospora crassa using FARM by Dreyfuss, Jonathan M, Zucker, Jeremy D, Hood, Heather M, Ocasio, Linda R, Sachs, Matthew S, Galagan, James E

“…The filamentous fungus Neurospora crassa played a central role in the development of twentieth-century genetics, biochemistry and molecular biology, and…”
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Structure and function of the yeast listerin (Ltn1) conserved N-terminal domain in binding to stalled 60S ribosomal subunits by Doamekpor, Selom K., Lee, Joong-Won, Hepowit, Nathaniel L., Wu, Cheng, Charenton, Clement, Leonard, Marilyn, Bengtson, Mario H., Rajashankar, Kanagalaghatta R., Sachs, Matthew S., Lima, Christopher D., Joazeiro, Claudio A. P.

“…The Ltn1 E3 ligase (listerin in mammals) has emerged as a paradigm for understanding ribosome-associated ubiquitylation. Ltn1 binds to 60S ribosomal subunits…”
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Site-Specific Release of Nascent Chains from Ribosomes at a Sense Codon by Doronina, Victoria A., Wu, Cheng, de Felipe, Pablo, Sachs, Matthew S., Ryan, Martin D., Brown, Jeremy D.

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Ribosome Occupancy of the Yeast CPA1 Upstream Open Reading Frame Termination Codon Modulates Nonsense-Mediated mRNA Decay by Gaba, Anthony, Jacobson, Allan, Sachs, Matthew S.

“…Saccharomyces cerevisiae CPA1 mRNA contains an upstream open reading frame (uORF) encoding the arginine attenuator peptide (AAP). Negative translational…”
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Draft de novo transcriptome assembly and proteome characterization of the electric lobe of Tetronarce californica: a molecular tool for the study of cholinergic neurotransmission in the electric organ by Stavrianakou, Maria, Perez, Ricardo, Wu, Cheng, Sachs, Matthew S, Aramayo, Rodolfo, Harlow, Mark

“…The electric organ of Tetronarce californica (an electric ray formerly known as Torpedo californica) is a classic preparation for biochemical studies of…”
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Evolutionary Roles of Upstream Open Reading Frames in Mediating Gene Regulation in Fungi by HOOD, Heather M, NEAFSEY, Daniel E, GALAGAN, James, SACHS, Matthew S

“…Upstream open reading frames (uORFs) are frequently present in the 5'-leader regions of fungal mRNAs. They can affect translation by controlling the ability of…”
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Translation Initiation from Conserved Non-AUG Codons Provides Additional Layers of Regulation and Coding Capacity by Ivanov, Ivaylo P, Wei, Jiajie, Caster, Stephen Z, Smith, Kristina M, Michel, Audrey M, Zhang, Ying, Firth, Andrew E, Freitag, Michael, Dunlap, Jay C, Bell-Pedersen, Deborah, Atkins, John F, Sachs, Matthew S

“…and are homologs specifying transcription activators that drive the transcriptional response to amino acid limitation. The mRNA contains two upstream open…”
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