Search Results - "Sachs, Jonathan N."

Interleaflet Interaction and Asymmetry in Phase Separated Lipid Bilayers: Molecular Dynamics Simulations by Perlmutter, Jason D, Sachs, Jonathan N

“…In order to investigate experimentally inaccessible, molecular-level detail regarding interleaflet interaction in membranes, we have run an extensive series of…”
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Interpretation of Fluctuation Spectra in Lipid Bilayer Simulations by Brandt, Erik G., Braun, Anthony R., Sachs, Jonathan N., Nagle, John F., Edholm, Olle

“…Atomic resolution and coarse-grained simulations of dimyristoylphosphatidylcholine lipid bilayers were analyzed for fluctuations perpendicular to the bilayer…”
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The Methionine-aromatic Motif Plays a Unique Role in Stabilizing Protein Structure by Valley, Christopher C., Cembran, Alessandro, Perlmutter, Jason D., Lewis, Andrew K., Labello, Nicholas P., Gao, Jiali, Sachs, Jonathan N.

“…Of the 20 amino acids, the precise function of methionine (Met) remains among the least well understood. To establish a determining characteristic of…”
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Lipid Bilayer Structure Determined by the Simultaneous Analysis of Neutron and X-Ray Scattering Data by Kučerka, Norbert, Nagle, John F., Sachs, Jonathan N., Feller, Scott E., Pencer, Jeremy, Jackson, Andrew, Katsaras, John

“…Quantitative structures were obtained for the fully hydrated fluid phases of dioleoylphosphatidylcholine (DOPC) and dipalmitoylphosphatidylcholine (DPPC)…”
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How Do Ethanolamine Plasmalogens Contribute to Order and Structure of Neurological Membranes? by West, Ana, Zoni, Valeria, Teague, Walter E, Leonard, Alison N, Vanni, Stefano, Gawrisch, Klaus, Tristram-Nagle, Stephanie, Sachs, Jonathan N, Klauda, Jeffery B

“…Ethanolamine plasmalogen (EtnPLA) is a conical-shaped ether lipid and an essential component of neurological membranes. Low stability against oxidation limits…”
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Targeting the ensemble of heterogeneous tau oligomers in cells: A novel small molecule screening platform for tauopathies by Lo, Chih Hung, Lim, Colin Kin-Wye, Ding, Zhipeng, Wickramasinghe, Sanjula P., Braun, Anthony R., Ashe, Karen H., Rhoades, Elizabeth, Thomas, David D., Sachs, Jonathan N.

“…Understanding the heterogeneous pathology in Alzheimer's disease and related tauopathies is one of the most urgent and fundamental challenges facing the…”
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Nimesulide, a COX-2 inhibitor, sensitizes pancreatic cancer cells to TRAIL-induced apoptosis by promoting DR5 clustering by Vunnam, Nagamani, Young, Malaney C., Liao, Elly E., Lo, Chih Hung, Huber, Evan, Been, MaryJane, Thomas, David D., Sachs, Jonathan N.

“…Nimesulide is a nonsteroidal anti-inflammatory drug and a COX-2 inhibitor with antitumor and antiproliferative activities that induces apoptosis in oral,…”
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Determination of Electron Density Profiles and Area from Simulations of Undulating Membranes by Braun, Anthony R., Brandt, Erik G., Edholm, Olle, Nagle, John F., Sachs, Jonathan N.

“…The traditional method for extracting electron density and other transmembrane profiles from molecular dynamics simulations of lipid bilayers fails for large…”
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α-Synuclein Reduces Tension and Increases Undulations in Simulations of Small Unilamellar Vesicles by Braun, Anthony R., Sachs, Jonathan N.

“…Using coarse-grained molecular dynamics simulations we have explored the effect of α-Synuclein (αSyn) on the structural and mechanical properties of small…”
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The Effect of Cholesterol on Short- and Long-Chain Monounsaturated Lipid Bilayers as Determined by Molecular Dynamics Simulations and X-Ray Scattering by Kučerka, Norbert, Perlmutter, Jason D., Pan, Jianjun, Tristram-Nagle, Stephanie, Katsaras, John, Sachs, Jonathan N.

“…We investigate the structure of cholesterol-containing membranes composed of either short-chain (diC14:1PC) or long-chain (diC22:1PC) monounsaturated…”
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Oxidation increases the strength of the methionine-aromatic interaction by Lewis, Andrew K, Dunleavy, Katie M, Senkow, Tiffany L, Her, Cheng, Horn, Benjamin T, Jersett, Mark A, Mahling, Ryan, McCarthy, Megan R, Perell, Gabriella T, Valley, Christopher C, Karim, Christine B, Gao, Jiali, Pomerantz, William C K, Thomas, David D, Cembran, Alessandro, Hinderliter, Anne, Sachs, Jonathan N

“…Editorial summary A combination of statistical analysis, quantum mechanics calculations and biophysical analytical approaches shows that methionine oxidation…”
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Indirubin Inhibits TRAIL-Induced Activation of Death Receptor 5 in Jurkat Cells by Young, Malaney C., Vunnam, Nagamani, Rebbeck, Robyn T., Yuen, Samantha L., Thomas, David D., Sachs, Jonathan N.

“…Death receptor 5 (DR5) is an apoptosis-inducing membrane receptor that mediates cell death in several life-threatening conditions. There is a crucial need for…”
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Advancements in a FRET Biosensor for Live-Cell Fluorescence-Lifetime High-Throughput Screening of Alpha-Synuclein by Braun, Anthony R., Kochen, Noah Nathan, Yuen, Samantha L., Liao, Elly E., Cornea, Razvan L., Thomas, David D., Sachs, Jonathan N.

“…There is a critical need for small molecules capable of rescuing pathophysiological phenotypes induced by alpha-synuclein (aSyn) misfolding and…”
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Understanding the Hofmeister Effect in Interactions between Chaotropic Anions and Lipid Bilayers:  Molecular Dynamics Simulations by Sachs, Jonathan N, Woolf, Thomas B

“…A set of all-atom molecular dynamics simulations have been performed to better understand critical phenomena regarding a Hofmeister series of anions and lipid…”
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Potent inhibitors of toxic alpha-synuclein identified via cellular time-resolved FRET biosensors by Braun, Anthony R., Liao, Elly E., Horvath, Mian, Kalra, Prakriti, Acosta, Karen, Young, Malaney C., Kochen, Noah Nathan, Lo, Chih Hung, Brown, Roland, Evans, Michael D., Pomerantz, William C. K., Rhoades, Elizabeth, Luk, Kelvin, Cornea, Razvan L., Thomas, David D., Sachs, Jonathan N.

“…We have developed a high-throughput drug discovery platform, measuring fluorescence resonance energy transfer (FRET) with fluorescent alpha-synuclein (αSN)…”
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Atomistic simulations of biologically realistic transmembrane potential gradients by Sachs, Jonathan N, Crozier, Paul S, Woolf, Thomas B

“…We present all-atom molecular dynamics simulations of biologically realistic transmembrane potential gradients across a DMPC bilayer. These simulations are the…”
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Open and Closed Conformations of the Isolated Transmembrane Domain of Death Receptor 5 Support a New Model of Activation by Lewis, Andrew K., James, Zachary M., McCaffrey, Jesse E., Braun, Anthony R., Karim, Christine B., Thomas, David D., Sachs, Jonathan N.

“…It has long been presumed that activation of the apoptosis-initiating Death Receptor 5, as well as other structurally homologous members of the TNF-receptor…”
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Changes in Phosphatidylcholine Headgroup Tilt and Water Order Induced by Monovalent Salts: Molecular Dynamics Simulations by Sachs, Jonathan N., Nanda, Hirsh, Petrache, Horia I., Woolf, Thomas B.

“…The association between monovalent salts and neutral lipid bilayers is known to influence global bilayer structural properties such as headgroup conformational…”
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HuR's post-transcriptional regulation of death receptor 5 in pancreatic cancer cells by Pineda, Danielle M., Rittenhouse, David W., Valley, Christopher C., Cozzitorto, Joseph A., Burkhart, Richard A., Leiby, Benjamin, Winter, Jordan M., Weber, Matthew C., Londin, Eric R., Rigoutsos, Isidore, Yeo, Charles J., Gorospe, Myriam, Witkiewicz, Agnieska K., Sachs, Jonathan N., Brody, Jonathan R.

“…Apoptosis is one of the core signaling pathways disrupted in pancreatic ductal adenocarcinoma (PDA). Death receptor 5 (DR5) is a member of the tumor necrosis…”
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Conformational states of TNFR1 as a molecular switch for receptor function by Lo, Chih Hung, Huber, Evan C., Sachs, Jonathan N.

“…Tumor necrosis factor receptor 1 (TNFR1) is a transmembrane receptor that plays a key role in the regulation of the inflammatory pathway. While inhibition of…”
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