Search Results - "Sachs, D H"

Long‐Term Results in Recipients of Combined HLA‐Mismatched Kidney and Bone Marrow Transplantation Without Maintenance Immunosuppression by Kawai, T., Sachs, D. H., Sprangers, B., Spitzer, T. R., Saidman, S. L., Zorn, E., Tolkoff‐Rubin, N., Preffer, F., Crisalli, K., Gao, B., Wong, W., Morris, H., LoCascio, S. A., Sayre, P., Shonts, B., Williams, W. W., Smith, R.‐N., Colvin, R. B., Sykes, M., Cosimi, A. B.

“…We report here the long‐term results of HLA‐mismatched kidney transplantation without maintenance immunosuppression (IS) in 10 subjects following combined…”
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Vascularized Composite Allograft Tolerance Across MHC Barriers in a Large Animal Model by Leonard, D. A., Kurtz, J. M., Mallard, C., Albritton, A., Duran‐Struuck, R., Farkash, E. A., Crepeau, R., Matar, A., Horner, B. M., Randolph, M. A., Sachs, D. H., Huang, C. A., Cetrulo, C. L.

“…Vascularized composite allograft (VCA) transplantation can restore form and function following severe craniofacial injuries, extremity amputations or massive…”
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Transgenic Expression of Human CD47 Markedly Increases Engraftment in a Murine Model of Pig‐to‐Human Hematopoietic Cell Transplantation by Tena, A., Kurtz, J., Leonard, D. A., Dobrinsky, J. R., Terlouw, S. L., Mtango, N., Verstegen, J., Germana, S., Mallard, C., Arn, J. S., Sachs, D. H., Hawley, R. J.

“…Mixed chimerism approaches for induction of tolerance of solid organ transplants have been applied successfully in animal models and in the clinic. However, in…”
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Use of CTLA4Ig for Induction of Mixed Chimerism and Renal Allograft Tolerance in Nonhuman Primates by Yamada, Y., Ochiai, T., Boskovic, S., Nadazdin, O., Oura, T., Schoenfeld, D., Cappetta, K., Smith, R.‐N., Colvin, R. B., Madsen, J. C., Sachs, D. H., Benichou, G., Cosimi, A. B., Kawai, T.

“…We have previously reported successful induction of renal allograft tolerance via a mixed chimerism approach in nonhuman primates. In those studies, we found…”
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Mechanisms of Donor‐Specific Tolerance in Recipients of Haploidentical Combined Bone Marrow/Kidney Transplantation by Andreola, G., Chittenden, M., Shaffer, J., Cosimi, A. B., Kawai, T., Cotter, P., LoCascio, S. A., Morokata, T., Dey, B. R., Tolkoff‐Rubin, N. T., Preffer, F., Bonnefoix, T., Kattleman, K., Spitzer, T. R., Sachs, D. H., Sykes, M.

“…We recently reported long‐term organ allograft survival without ongoing immunosuppression in four of five patients receiving combined kidney and bone marrow…”
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Overcoming Memory T‐Cell Responses for Induction of Delayed Tolerance in Nonhuman Primates by Yamada, Y., Boskovic, S., Aoyama, A., Murakami, T., Putheti, P., Smith, R. N., Ochiai, T., Nadazdin, O., Koyama, I., Boenisch, O., Najafian, N., Bhasin, M. K., Colvin, R. B., Madsen, J. C., Strom, T. B., Sachs, D. H., Benichou, G., Cosimi, A. B., Kawai, T.

“…The presence of alloreactive memory T cells is a major barrier for induction of tolerance in primates. In theory, delaying conditioning for tolerance induction…”
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Myeloma Responses and Tolerance Following Combined Kidney and Nonmyeloablative Marrow Transplantation: In Vivo and In Vitro Analyses by Fudaba, Y., Spitzer, T. R., Shaffer, J., Kawai, T., Fehr, T., Delmonico, F., Preffer, F., Tolkoff‐Rubin, N., Dey, B. R., Saidman, S. L., Kraus, A., Bonnefoix, T., McAfee, S., Power, K., Kattleman, K., Colvin, R. B., Sachs, D. H., Cosimi, A. B., Sykes, M.

“…Six patients with renal failure due to multiple myeloma (MM) received simultaneous kidney and bone marrow transplantation (BMT) from HLA‐identical sibling…”
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Acute Renal Endothelial Injury During Marrow Recovery in a Cohort of Combined Kidney and Bone Marrow Allografts by Farris, A.B., Taheri, D., Kawai, T., Fazlollahi, L., Wong, W., Tolkoff‐Rubin, N., Spitzer, T. R., Iafrate, A. J., Preffer, F. I., LoCascio, S. A., Sprangers, B., Saidman, S., Smith, R. N., Cosimi, A. B., Sykes, M., Sachs, D. H., Colvin, R. B.

“…An idiopathic capillary leak syndrome (‘engraftment syndrome’) often occurs in recipients of hematopoietic cells, manifested clinically by transient azotemia…”
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Results of Gal‐Knockout Porcine Thymokidney Xenografts by Griesemer, A. D., Hirakata, A., Shimizu, A., Moran, S., Tena, A., Iwaki, H., Ishikawa, Y., Schule, P., Arn, J. S., Robson, S. C., Fishman, J. A., Sykes, M., Sachs, D. H., Yamada, K.

“…Clinical transplantation for the treatment of end‐stage organ disease is limited by a shortage of donor organs. Successful xenotransplantation could…”
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Four Stages and Lack of Stable Accommodation in Chronic Alloantibody‐Mediated Renal Allograft Rejection in Cynomolgus Monkeys by Smith, R. N., Kawai, T., Boskovic, S., Nadazdin, O., Sachs, D. H., Cosimi, A. B., Colvin, R. B.

“…The etiology of immunologically mediated chronic renal allograft failure is unclear. One cause is thought to be alloantibodies. Previously in Cynomolgus…”
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Depletion of CD8 Memory T Cells for Induction of Tolerance of a Previously Transplanted Kidney Allograft by Koyama, I., Nadazdin, O., Boskovic, S., Ochiai, T., Smith, R. N., Sykes, M., Sogawa, H., Murakami, T., Strom, T. B., Colvin, R. B., Sachs, D. H., Benichou, G., Cosimi, A. B., Kawai, T.

“…Heterologous immunologic memory has been considered a potent barrier to tolerance induction in primates. Induction of such tolerance for a previously…”
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Bortezomib, C1‐Inhibitor and Plasma Exchange Do Not Prolong the Survival of Multi‐Transgenic GalT‐KO Pig Kidney Xenografts in Baboons by Le Bas‐Bernardet, S., Tillou, X., Branchereau, J., Dilek, N., Poirier, N., Châtelais, M., Charreau, B., Minault, D., Hervouet, J., Renaudin, K., Crossan, C., Scobie, L., Takeuchi, Y., Diswall, M., Breimer, M. E., Klar, N., Daha, M. R., Simioni, P., Robson, S. C., Nottle, M. B., Salvaris, E. J., Cowan, P. J., d'Apice, A. J. F., Sachs, D. H., Yamada, K., Lagutina, I., Duchi, R., Perota, A., Lazzari, G., Galli, C., Cozzi, E., Soulillou, J.‐P., Vanhove, B., Blancho, G.

“…Galactosyl‐transferase KO (GalT‐KO) pigs represent a potential solution to xenograft rejection, particularly in the context of additional genetic…”
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Phenotype, Distribution and Alloreactive Properties of Memory T Cells from Cynomolgus Monkeys by Nadazdin, Ognjenka, Boskovic, Svjetlan, Murakami, Toru, O’Connor, D. H., Wiseman, Roger W., Karl, J. A., Tuscher, J. J., Sachs, D. H., Madsen, J. C., Tocco, Georges, Kawai, Tatsuo, Cosimi, A. B., Benichou, Gilles

“…The high frequency of memory T cells present in primates is thought to represent a major barrier to tolerance induction in transplantation. Therefore, it is…”
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Induction of Cardiac Allograft Tolerance Across a Full MHC Barrier in Miniature Swine by Donor Kidney Cotransplantation by Madariaga, M. L., Michel, S. G., Tasaki, M., Villani, V., La Muraglia, G. M., Sihag, S., Gottschall, J., Farkash, E. A., Shimizu, A., Allan, J. S., Sachs, D. H., Yamada, K., Madsen, J. C.

“…We have previously shown that tolerance of kidney allografts across a full major histocompatibility complex (MHC) barrier can be induced in miniature swine by…”
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B‐Cell Immunity in the Context of T‐Cell Tolerance after Combined Kidney and Bone Marrow Transplantation in Humans by Porcheray, F., Wong, W., Saidman, S. L., De Vito, J., Girouard, T. C., Chittenden, M., Shaffer, J., Tolkoff‐Rubin, N., Dey, B. R., Spitzer, T. R., Colvin, R. B., Cosimi, A. B., Kawai, T., Sachs, D. H., Sykes, M., Zorn, E.

“…Five patients with end‐stage kidney disease received combined kidney and bone marrow transplants from HLA haploidentical donors following nonmyeloablative…”
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The effects of brain death and ischemia on tolerance induction are organ‐specific by Michel, S. G., Madariaga, M. L. L., LaMuraglia, G. M., Villani, V., Sekijima, M., Farkash, E. A., Colvin, R. B., Sachs, D. H., Yamada, K., Rosengard, B. R., Allan, J. S., Madsen, J. C.

“…We have previously shown that 12 days of high‐dose calcineurin inhibition induced tolerance in MHC inbred miniature swine receiving MHC‐mismatched lung,…”
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The Induction of Tolerance of Renal Allografts by Adoptive Transfer in Miniature Swine by Okumi, M., Scalea, J. R., Gillon, B. C., Tasaki, M., Villani, V., Cormack, T., Hirakata, A., Shimizu, A., Sachs, D. H., Yamada, K.

“…Our previous in vitro data have demonstrated that regulatory mechanisms are involved in tolerance of class I‐mismatched renal allografts in miniature swine…”
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Renal and Cardiac Endothelial Heterogeneity Impact Acute Vascular Rejection in Pig‐to‐Baboon Xenotransplantation by Knosalla, C., Yazawa, K., Behdad, A., Bodyak, N., Shang, H., Bühler, L., Houser, S., Gollackner, B., Griesemer, A., Schmitt‐Knosalla, I., Schuurman, H.‐J., Awwad, M., Sachs, D. H., Cooper, D. K. C., Yamada, K., Usheva, A., Robson, S. C.

“…Xenograft outcomes are dictated by xenoantigen expression, for example, Gal α1, 3Gal (Gal), but might also depend on differing vascular responses. We…”
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High-dose porcine hematopoietic cell transplantation combined with CD40 ligand blockade in baboons prevents an induced anti-pig humoral response by BÜHLER, L, AWWAD, M, DOWN, J. D, SYKES, M, ANDREWS, D, SACKSTEIN, R, WHITE-SCHARF, M. E, SACHS, D. H, COOPER, D. K. C, BASKER, M, GOJO, S, WATTS, A, TRETER, S, NASH, K, ORAVEC, G, CHANG, Q, THALL, A

“…In pig-to-primate organ transplantation, hyperacute rejection can be prevented, but the organ is rejected within days by acute vascular rejection, in which…”
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Evidence for a Gene Controlling the Induction of Transplantation Tolerance by Lee, P. W., Hanekamp, J. S., Villani, V., Vagefi, P. A., Cina, R. A., Kamano, C., O'Malley, P. E., Arn, S., Yamada, K., Sachs, D. H.

“…Class I mismatched kidney transplantation in Massachusetts General Hospital MHC‐defined miniature swine has been studied extensively as a model for induction…”
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