Search Results - "Sachdeva, Sarbjot"

Synthesis and biological evaluation of novel sulfonyl-naphthalene-1,4-diols as FabH inhibitors by Alhamadsheh, Mamoun M., Waters, Norman C., Sachdeva, Sarbjot, Lee, Patricia, Reynolds, Kevin A.

“…A series of analogs of 2-tosylnaphthalene-1,4-diol were prepared and were found to be potent 10–20 nM reversible inhibitors of the Escherichia coli FabH…”
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Crystal Structure of a Substrate Complex of Mycobacterium tuberculosis β-Ketoacyl-acyl Carrier Protein Synthase III (FabH) with Lauroyl-coenzyme A by Musayev, Faik, Sachdeva, Sarbjot, Neel Scarsdale, J., Reynolds, K.A., Wright, H.T.

“…β-Ketoacyl-acyl carrier protein synthase III (FabH) catalyzes a two step reaction that initiates the pathway of fatty acid biosynthesis in plants and bacteria…”
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Mycobacterium tuberculosis beta-ketoacyl acyl carrier protein synthase III (mtFabH) assay: principles and method by Sachdeva, Sarbjot, Reynolds, Kevin A

“…Fatty acid biosynthesis is one of the relatively newer targets in antibacterial drug discovery. The presence of distinct fatty acid synthases (FAS) in mammals…”
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Probing reactivity and substrate specificity of both subunits of the dimeric Mycobacterium tuberculosis FabH using alkyl-CoA disulfide inhibitors and acyl-CoA substrates by Sachdeva, Sarbjot, Musayev, Faik, Alhamadsheh, Mamoun M., Neel Scarsdale, J., Tonie Wright, H., Reynolds, Kevin A.

“…The dimeric Mycobacterium tuberculosis FabH (mtFabH) catalyses a Claisen-type condensation between an acyl-CoA and malonyl-acyl carrier protein (ACP) to…”
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Interactions of mtFabH with its substrates and inhibitors reveal novel mechanistic insights by Sachdeva, Sarbjot Singh

“…Tuberculosis emerged from its grave to be one of the deadliest diseases of the present time after recently developing a synergy with AIDS. A fatty acid…”
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Alkyl-CoA Disulfides as Inhibitors and Mechanistic Probes for FabH Enzymes by Alhamadsheh, Mamoun M., Musayev, Faik, Komissarov, Andrey A., Sachdeva, Sarbjot, Wright, H. Tonie, Scarsdale, Neel, Florova, Galina, Reynolds, Kevin A.

“…The first step of the reaction catalyzed by the homodimeric FabH from a dissociated fatty acid synthase is acyl transfer from acyl-CoA to an active site…”
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Separate Entrance and Exit Portals for Ligand Traffic in Mycobacterium tuberculosis FabH by Sachdeva, Sarbjot, Musayev, Faik N., Alhamadsheh, Mamoun M., Scarsdale, J. Neel, Wright, H. Tonie, Reynolds, Kevin A.

“…Mycobacterium tuberculosis FabH initiates type II fatty acid synthase-catalyzed formation of the long chain (C 16–C 22) acyl-coenzyme A (CoA) precursors of…”
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