Search Results - "Sachdev, Vinay"

ATGL/CGI-58-Dependent Hydrolysis of a Lipid Storage Pool in Murine Enterocytes by Korbelius, Melanie, Vujic, Nemanja, Sachdev, Vinay, Obrowsky, Sascha, Rainer, Silvia, Gottschalk, Benjamin, Graier, Wolfgang F., Kratky, Dagmar

“…As circulating lipid levels are balanced by the rate of lipoprotein release and clearance from the plasma, lipid absorption in the small intestine critically…”
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Hepatic SREBP signaling requires SPRING to govern systemic lipid metabolism in mice and humans by Hendrix, Sebastian, Kingma, Jenina, Ottenhoff, Roelof, Valiloo, Masoud, Svecla, Monika, Zijlstra, Lobke F., Sachdev, Vinay, Kovac, Kristina, Levels, Johannes H. M., Jongejan, Aldo, de Boer, Jan F., Kuipers, Folkert, Rimbert, Antoine, Norata, Giuseppe D., Loregger, Anke, Zelcer, Noam

“…The sterol regulatory element binding proteins (SREBPs) are transcription factors that govern cholesterol and fatty acid metabolism. We recently identified…”
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The PPARα Agonist Fenofibrate Prevents Formation of Protein Aggregates (Mallory-Denk bodies) in a Murine Model of Steatohepatitis-like Hepatotoxicity by Nikam, Aniket, Patankar, Jay V., Somlapura, Meghana, Lahiri, Pooja, Sachdev, Vinay, Kratky, Dagmar, Denk, Helmut, Zatloukal, Kurt, Abuja, Peter M.

“…Chronic intoxication of mice with the porphyrinogenic compound 3,5-diethoxycarbonyl-1,4-dihydrocollidine (DDC) leads to morphological and metabolic changes…”
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Phospholipid Transfer Protein Is Expressed in Cerebrovascular Endothelial Cells and Involved in High Density Lipoprotein Biogenesis and Remodeling at the Blood-Brain Barrier by Chirackal Manavalan, Anil Paul, Kober, Alexandra, Metso, Jari, Lang, Ingrid, Becker, Tatjana, Hasslitzer, Karin, Zandl, Martina, Fanaee-Danesh, Elham, Pippal, Jyotsna Brijesh, Sachdev, Vinay, Kratky, Dagmar, Stefulj, Jasminka, Jauhiainen, Matti, Panzenboeck, Ute

“…Phospholipid transfer protein (PLTP) is a key protein involved in biogenesis and remodeling of plasma HDL. Several neuroprotective properties have been…”
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Impaired Bile Acid Metabolism and Gut Dysbiosis in Mice Lacking Lysosomal Acid Lipase by Sachdev, Vinay, Duta-Mare, Madalina, Korbelius, Melanie, Vujić, Nemanja, Leopold, Christina, Freark de Boer, Jan, Rainer, Silvia, Fickert, Peter, Kolb, Dagmar, Kuipers, Folkert, Radovic, Branislav, Gorkiewicz, Gregor, Kratky, Dagmar

“…Lysosomal acid lipase (LAL) is the sole enzyme known to be responsible for the hydrolysis of cholesteryl esters and triglycerides at an acidic pH in lysosomes,…”
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Defective Lipid Droplet–Lysosome Interaction Causes Fatty Liver Disease as Evidenced by Human Mutations in TMEM199 and CCDC115 by Larsen, Lars E., van den Boogert, Marjolein A.W., Rios-Ocampo, Wilson A., Jansen, Jos C., Conlon, Donna, Chong, Patrick L.E., Levels, J. Han M., Eilers, Roos E., Sachdev, Vinay V., Zelcer, Noam, Raabe, Tobias, He, Miao, Hand, Nicholas J., Drenth, Joost P.H., Rader, David J., Stroes, Eric S.G., Lefeber, Dirk J., Jonker, Johan W., Holleboom, Adriaan G.

“…Recently, novel inborn errors of metabolism were identified because of mutations in V-ATPase assembly factors TMEM199 and CCDC115. Patients are characterized…”
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Deletion of CGI-58 or adipose triglyceride lipase differently affects macrophage function and atherosclerosis[S] by Goeritzer, Madeleine, Schlager, Stefanie, Radovic, Branislav, Madreiter, Corina T., Rainer, Silvia, Thomas, Gwynneth, Lord, Caleb C., Sacks, Jessica, Brown, Amanda L., Vujic, Nemanja, Obrowsky, Sascha, Sachdev, Vinay, Kolb, Dagmar, Chandak, Prakash G., Graier, Wolfgang F., Sattler, Wolfgang, Brown, J. Mark, Kratky, Dagmar

“…Cellular TG stores are efficiently hydrolyzed by adipose TG lipase (ATGL). Its coactivator comparative gene identification-58 (CGI-58) strongly increases…”
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Presenilin-1 Established ER-Ca2+ Leak: a Follow Up on Its Importance for the Initial Insulin Secretion in Pancreatic Islets and β-Cells Upon Elevated Glucose by Klec, Christiane, Madreiter-Sokolowski, Corina T, Ziomek, Gabriela, Stryeck, Sarah, Sachdev, Vinay, Duta-Mare, Madalina, Gottschalk, Benjamin, Depaoli, Maria R, Rost, Rene, Hay, Jesse, Waldeck-Weiermair, Markus, Kratky, Dagmar, Madl, Tobias, Malli, Roland, Graier, Wolfgang F

“…BACKGROUND/AIMSIn our recent work, the importance of GSK3β-mediated phosphorylation of presenilin-1 as crucial process to establish a Ca2+ leak in the…”
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Glycogen Synthase Kinase 3 Beta Controls Presenilin-1-Mediated Endoplasmic Reticulum Ca²⁺ Leak Directed to Mitochondria in Pancreatic Islets and β-Cells by Klec, Christiane, Madreiter-Sokolowski, Corina T, Stryeck, Sarah, Sachdev, Vinay, Duta-Mare, Madalina, Gottschalk, Benjamin, Depaoli, Maria R, Rost, Rene, Hay, Jesse, Waldeck-Weiermair, Markus, Kratky, Dagmar, Madl, Tobias, Malli, Roland, Graier, Wolfgang F

“…In pancreatic β-cells, the intracellular Ca²⁺ homeostasis is an essential regulator of the cells major functions. The endoplasmic reticulum (ER) as interactive…”
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Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice by Gali, Chaitanya Chakravarthi, Fanaee-Danesh, Elham, Zandl-Lang, Martina, Albrecher, Nicole Maria, Tam-Amersdorfer, Carmen, Stracke, Anika, Sachdev, Vinay, Reichmann, Florian, Sun, Yidan, Avdili, Afrim, Reiter, Marielies, Kratky, Dagmar, Holzer, Peter, Lass, Achim, Kandimalla, Karunya K., Panzenboeck, Ute

“…Aberrant insulin signaling constitutes an early change in Alzheimer's disease (AD). Insulin receptors (IR) and low-density lipoprotein receptor-related…”
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Intestine-specific DGAT1 deficiency improves atherosclerosis in apolipoprotein E knockout mice by reducing systemic cholesterol burden by Vujić, Nemanja, Korbelius, Melanie, Sachdev, Vinay, Rainer, Silvia, Zimmer, Andreas, Huber, Anton, Radović, Branislav, Kratky, Dagmar

“…Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is the rate-limiting enzyme catalyzing the final step of triglyceride synthesis by esterifying a diglyceride…”
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Gut microbiota inhibit Asbt-dependent intestinal bile acid reabsorption via Gata4 by Out, Carolien, Patankar, Jay V, Doktorova, Marcela, Boesjes, Marije, Bos, Trijnie, de Boer, Sanna, Havinga, Rick, Wolters, Henk, Boverhof, Renze, van Dijk, Theo H, Smoczek, Anna, Bleich, André, Sachdev, Vinay, Kratky, Dagmar, Kuipers, Folkert, Verkade, Henkjan J, Groen, Albert K

“…Background & Aims Regulation of bile acid homeostasis in mammals is a complex process regulated via extensive cross-talk between liver, intestine and…”
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MiR-206 is expressed in pancreatic islets and regulates glucokinase activity by Vinod, Manjula, Patankar, Jay V, Sachdev, Vinay, Frank, Saša, Graier, Wolfgang F, Kratky, Dagmar, Kostner, Gerhard M

“…Glucose homeostasis is a complex indispensable process, and its dysregulation causes hyperglycemia and type 2 diabetes mellitus. Glucokinase (GK) takes a…”
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Hepatocyte-specific lysosomal acid lipase deficiency protects mice from diet-induced obesity but promotes hepatic inflammation by Leopold, Christina, Duta-Mare, Madalina, Sachdev, Vinay, Goeritzer, Madeleine, Maresch, Lisa Katharina, Kolb, Dagmar, Reicher, Helga, Wagner, Bettina, Stojakovic, Tatjana, Ruelicke, Thomas, Haemmerle, Guenter, Hoefler, Gerald, Sattler, Wolfgang, Kratky, Dagmar

“…Lysosomal acid lipase (LAL) hydrolyzes cholesteryl esters (CE) and triglycerides (TG) to generate fatty acids (FA) and cholesterol. LAL deficiency (LAL-D) in…”
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Lysosomal acid lipase and thermoregulation during cold exposure by Duta-Mare, Madalina, Sachdev, Vinay, Vujic, Nemanja, Huber, Katharina, Xia, Wenmin, Korbelius, Melanie, Kratky, Dagmar

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Lysosomal acid lipase regulates fatty acid channeling in brown adipose tissue to maintain thermogenesis by Duta-Mare, Madalina, Sachdev, Vinay, Leopold, Christina, Kolb, Dagmar, Vujic, Nemanja, Korbelius, Melanie, Hofer, Dina C., Xia, Wenmin, Huber, Katharina, Auer, Martina, Gottschalk, Benjamin, Magnes, Christoph, Graier, Wolfgang F., Prokesch, Andreas, Radovic, Branislav, Bogner-Strauss, Juliane G., Kratky, Dagmar

“…Lysosomal acid lipase (LAL) is the only known enzyme, which hydrolyzes cholesteryl esters and triacylglycerols in lysosomes of multiple cells and tissues…”
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Novel amino-β-lactam derivatives as potent cholesterol absorption inhibitors by Dražić, Tonko, Molčanov, Krešimir, Sachdev, Vinay, Malnar, Martina, Hećimović, Silva, Patankar, Jay V., Obrowsky, Sascha, Levak-Frank, Sanja, Habuš, Ivan, Kratky, Dagmar

“…Two new trans-(3R,4R)-amino-β-lactam derivatives and their diastereoisomeric mixtures were synthesized as ezetimibe bioisosteres and tested in in vitro and…”
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Novel role of a triglyceride-synthesizing enzyme: DGAT1 at the crossroad between triglyceride and cholesterol metabolism by Sachdev, Vinay, Leopold, Christina, Bauer, Raimund, Patankar, Jay V., Iqbal, Jahangir, Obrowsky, Sascha, Boverhof, Renze, Doktorova, Marcela, Scheicher, Bernhard, Goeritzer, Madeleine, Kolb, Dagmar, Turnbull, Andrew V., Zimmer, Andreas, Hoefler, Gerald, Hussain, M. Mahmood, Groen, Albert K., Kratky, Dagmar

“…Acyl-CoA:diacylglycerol acyltransferase 1 (DGAT1) is a key enzyme in triacylglycerol (TG) biosynthesis. Here we show that genetic deficiency and…”
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Active autophagy but not lipophagy in macrophages with defective lipolysis by Goeritzer, Madeleine, Vujic, Nemanja, Schlager, Stefanie, Chandak, Prakash G., Korbelius, Melanie, Gottschalk, Benjamin, Leopold, Christina, Obrowsky, Sascha, Rainer, Silvia, Doddapattar, Prakash, Aflaki, Elma, Wegscheider, Martin, Sachdev, Vinay, Graier, Wolfgang F., Kolb, Dagmar, Radovic, Branislav, Kratky, Dagmar

“…During autophagy, autophagosomes fuse with lysosomes to degrade damaged organelles and misfolded proteins. Breakdown products are released into the cytosol and…”
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Synthesis and evaluation of novel amide amino-β-lactam derivatives as cholesterol absorption inhibitors by Dražić, Tonko, Sachdev, Vinay, Leopold, Christina, Patankar, Jay V., Malnar, Martina, Hećimović, Silva, Levak-Frank, Sanja, Habuš, Ivan, Kratky, Dagmar

“…[Display omitted] The β-lactam cholesterol absorption inhibitor ezetimibe is so far the only representative of this class of compounds on the market today. The…”
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