Search Results - "Sachdev, Robert N.S."

Motor Cortex Feedback Influences Sensory Processing by Modulating Network State by Zagha, Edward, Casale, Amanda E., Sachdev, Robert N.S., McGinley, Matthew J., McCormick, David A.

“…Long-range corticocortical communication may have important roles in context-dependent sensory processing, yet we know very little about how these pathways…”
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Chronic Cellular Imaging of Entire Cortical Columns in Awake Mice Using Microprisms by Andermann, Mark L., Gilfoy, Nathan B., Goldey, Glenn J., Sachdev, Robert N.S., Wölfel, Markus, McCormick, David A., Reid, R. Clay, Levene, Michael J.

“…Two-photon imaging of cortical neurons in vivo has provided unique insights into the structure, function, and plasticity of cortical networks, but this method…”
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Decreased Subcortical Cholinergic Arousal in Focal Seizures by Motelow, Joshua E., Li, Wei, Zhan, Qiong, Mishra, Asht M., Sachdev, Robert N.S., Liu, Geoffrey, Gummadavelli, Abhijeet, Zayyad, Zaina, Lee, Hyun Seung, Chu, Victoria, Andrews, John P., Englot, Dario J., Herman, Peter, Sanganahalli, Basavaraju G., Hyder, Fahmeed, Blumenfeld, Hal

“…Impaired consciousness in temporal lobe seizures has a major negative impact on quality of life. The prevailing view holds that this disorder impairs…”
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Whisking Asymmetry Signals Motor Preparation and the Behavioral State of Mice by Dominiak, Sina E, Nashaat, Mostafa A, Sehara, Keisuke, Oraby, Hatem, Larkum, Matthew E, Sachdev, Robert N S

“…A central function of the brain is to plan, predict, and imagine the effect of movement in a dynamically changing environment. Here we show that in mice…”
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Layer 6b Is Driven by Intracortical Long-Range Projection Neurons by Zolnik, Timothy A., Ledderose, Julia, Toumazou, Maria, Trimbuch, Thorsten, Oram, Tess, Rosenmund, Christian, Eickholt, Britta J., Sachdev, Robert N.S., Larkum, Matthew E.

“…Layer 6b (L6b), the deepest neocortical layer, projects to cortical targets and higher-order thalamus and is the only layer responsive to the wake-promoting…”
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Experimental model for functional magnetic resonance imaging of somatic sensory cortex in the unanesthetized rat by Sachdev, Robert N.S, Champney, Greg C, Lee, Haakil, Price, Ronald R, Pickens, David R, Morgan, Victoria L, Stefansic, James D, Melzer, Peter, Ebner, Ford F

“…Functional magnetic resonance imaging (fMRI) has evolved into a method widely used to map neural activation in the human brain. fMRI is a method for recording…”
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Thalamic input to motor cortex facilitates goal-directed action initiation by Takahashi, Naoya, Moberg, Sara, Zolnik, Timothy A., Catanese, Julien, Sachdev, Robert N.S., Larkum, Matthew E., Jaeger, Dieter

“…Prompt execution of planned motor action is essential for survival. The interactions between frontal cortical circuits and the basal ganglia are central to…”
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Layer 6b controls brain state via apical dendrites and the higher-order thalamocortical system by Zolnik, Timothy Adam, Bronec, Anna, Ross, Annemarie, Staab, Marcel, Sachdev, Robert N S, Molnár, Zoltán, Eickholt, Britta Johanna, Larkum, Matthew Evan

“…The deepest layer of the cortex (layer 6b [L6b]) contains relatively few neurons, but it is the only cortical layer responsive to the potent wake-promoting…”
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Improved methods for marking active neuron populations by Moeyaert, Benjamien, Holt, Graham, Madangopal, Rajtarun, Perez-Alvarez, Alberto, Fearey, Brenna C., Trojanowski, Nicholas F., Ledderose, Julia, Zolnik, Timothy A., Das, Aniruddha, Patel, Davina, Brown, Timothy A., Sachdev, Robert N. S., Eickholt, Britta J., Larkum, Matthew E., Turrigiano, Gina G., Dana, Hod, Gee, Christine E., Oertner, Thomas G., Hope, Bruce T., Schreiter, Eric R.

“…Marking functionally distinct neuronal ensembles with high spatiotemporal resolution is a key challenge in systems neuroscience. We recently introduced…”
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Efficient training approaches for optimizing behavioral performance and reducing head fixation time by Nasr, Anna, Dominiak, Sina E, Sehara, Keisuke, Nashaat, Mostafa A, Sachdev, Robert N. S, Larkum, Matthew E

“…The use of head fixation has become routine in systems neuroscience. However, whether the behavior changes with head fixation, whether animals can learn…”
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Layer 1 of somatosensory cortex: an important site for input to a tiny cortical compartment by Ledderose, Julia M T, Zolnik, Timothy A, Toumazou, Maria, Trimbuch, Thorsten, Rosenmund, Christian, Eickholt, Britta J, Jaeger, Dieter, Larkum, Matthew E, Sachdev, Robert N S

“…Abstract Neocortical layer 1 has been proposed to be at the center for top-down and bottom-up integration. It is a locus for interactions between long-range…”
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A Perspective on Cortical Layering and Layer-Spanning Neuronal Elements by Larkum, Matthew E, Petro, Lucy S, Sachdev, Robert N S, Muckli, Lars

“…This review article addresses the function of the layers of the cerebral cortex. We develop the perspective that cortical layering needs to be understood in…”
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The impact of phosphorylated PTEN at threonine 366 on cortical connectivity and behaviour by Ledderose, Julia M T, Benitez, Jorge A, Roberts, Amanda J, Reed, Rachel, Bintig, Willem, Larkum, Matthew E, Sachdev, Robert N S, Furnari, Frank, Eickholt, Britta J

“…The lipid phosphatase PTEN (phosphatase and tensin homologue on chromosome 10) is a key tumour suppressor gene and an important regulator of neuronal…”
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Delta rhythm in wakefulness: evidence from intracranial recordings in human beings by Sachdev, Robert N S, Gaspard, Nicolas, Gerrard, Jason L, Hirsch, Lawrence J, Spencer, Dennis D, Zaveri, Hitten P

“…A widely accepted view is that wakefulness is a state in which the entire cortical mantle is persistently activated, and therefore desynchronized…”
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Air-Track: a real-world floating environment for active sensing in head-fixed mice by Nashaat, Mostafa A, Oraby, Hatem, Sachdev, Robert N S, Winter, York, Larkum, Matthew E

“…Natural behavior occurs in multiple sensory and motor modalities and in particular is dependent on sensory feedback that constantly adjusts behavior. To…”
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State Changes Rapidly Modulate Cortical Neuronal Responsiveness by Hasenstaub, Andrea, Sachdev, Robert N. S, McCormick, David A

“…The responsiveness of cortical neurons is strongly and rapidly influenced by changes in the level of local network activity. In rodent somatosensory cortex,…”
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Up and Down States and Memory Consolidation Across Somatosensory, Entorhinal, and Hippocampal Cortices by Tukker, John J, Beed, Prateep, Schmitz, Dietmar, Larkum, Matthew E, Sachdev, Robert N S

“…In the course of a day, brain states fluctuate, from conscious awake information-acquiring states to sleep states, during which previously acquired information…”
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All‐optical functional synaptic connectivity mapping in acute brain slices using the calcium integrator CaMPARI by Zolnik, Timothy A., Sha, Fern, Johenning, Friedrich W., Schreiter, Eric R., Looger, Loren L., Larkum, Matthew E., Sachdev, Robert N. S.

“…Key points The genetically encoded fluorescent calcium integrator calcium‐modulated photoactivatable ratiobetric integrator (CaMPARI) reports calcium influx…”
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Dynamic correlation between whisking and breathing rhythms in mice by Cao, Ying, Roy, Snigdha, Sachdev, Robert N S, Heck, Detlef H

“…Sniffing, a high-frequency, highly rhythmic inhalation and exhalation of air through the nose, plays an important role in rodent olfaction. Similarly,…”
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Real-Time Closed-Loop Feedback in Behavioral Time Scales Using DeepLabCut by Sehara, Keisuke, Zimmer-Harwood, Paul, Larkum, Matthew E, Sachdev, Robert N S

“…Computer vision approaches have made significant inroads into offline tracking of behavior and estimating animal poses. In particular, because of their…”
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