Search Results - "Saccomani, M. P."

Comment on “Minimal and Maximal Models to Quantitate Glucose Metabolism: Tools to Measure, to Simulate and to Run in Silico Clinical Trials” by Eichenlaub, Manuel, Saccomani, M. P., Hattersley, John G., Khovanova, Natasha A.

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Role of tissue-specific blood flow and tissue recruitment in insulin-mediated glucose uptake of human skeletal muscle by BONADONNA, R. C, SACCOMANI, M. P, DEL PRATO, S, BONORA, E, DEFRONZO, R. A, COBELLI, C

“…Conflicting evidence exists concerning whether insulin-induced vasodilation plays a mechanistic role in the regulation of limb glucose uptake. It can be…”
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Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM by Bonadonna, R. C., Del Prato, S., Bonora, E., Saccomani, M. P., Gulli, G., Natali, A., Frascerra, S., Pecori, N., Ferrannini, E., Bier, D., Cobelli, C., DeFronzo, R. A.

“…Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM. R C Bonadonna , S Del Prato , E Bonora , M P Saccomani , G Gulli…”
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Global identifiability of linear compartmental models-a computer algebra algorithm by Audoly, S., D'Angio, L., Saccomani, M.P., Cobelli, C.

“…A priori global identifiability deals with the uniqueness of the solution for the unknown parameters of a model and is, thus, a prerequisite for parameter…”
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A model to measure insulin effects on glucose transport and phosphorylation in muscle: a three-tracer study by Saccomani, M.P. (University of Padua, Padua, Italy.), Bonadonna, R.C, Bier, D.M, DeFronzo, R.A, Cobelli, C

“…We studied five healthy subjects with perfused forearm and euglycemic clamp techniques in combination with a three-tracer (D-[12C] mannitol, not transportable;…”
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A compartmental model of zinc metabolism in healthy women using oral and intravenous stable isotope tracers by Lowe, NM, Shames, DM, Woodhouse, LR, Matel, JS, Roehl, R, Saccomani, MP, Toffolo, G, Cobelli, C, King, JC

“…A mathematical model of zinc metabolism in six healthy women (average age: 30 +/- 11 y) was developed by using stable isotopes of zinc. After equilibration on…”
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Effect of insulin on system A amino acid transport in human skeletal muscle by BONADONNA, R. C, SACCOMANI, M. P, COBELLI, C, DEFRONZO, R. A

“…Transmembrane transport of neutral amino acids in skeletal muscle is mediated by at least four different systems (system A, ASC, L, and Nm), and may be an…”
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Global identifiability of nonlinear models of biological systems by Audoly, S., Bellu, G., D'Angio, L., Saccomani, M.P., Cobelli, C.

“…A prerequisite for well-posedness of parameter estimation of biological and physiological systems is a priori global identifiability, a property which concerns…”
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Compartmental model of leucine kinetics in humans by Cobelli, C, Saccomani, M P, Tessari, P, Biolo, G, Luzi, L, Matthews, D E

“…The complexity of amino acid and protein metabolism has limited the development of comprehensive, accurate whole body kinetic models. For leucine, simplified…”
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Bicarbonate kinetics in humans: identification and validation of a three-compartment model by Saccomani, M P, Bonadonna, R C, Caveggion, E, DeFronzo, R A, Cobelli, C

“…A model of bicarbonate kinetics is crucial to a correct interpretation of experiments for measuring oxidation in vivo of carbon-labeled compounds. The aim of…”
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A minimal input-output configuration for a priori identifiability of a compartmental model of leucine metabolism by Saccomani, M.P., Cobelli, C.

“…To develop a model describing the structure and function of a metabolic system using data from an input-output experiment, it is useful to design a pilot…”
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Unappreciation of a priori identifiability in software packages causes ambiguities in numerical estimates by Cobelli, C, Saccomani, M P

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A compartmental model to quantitate in vivo glucose transport in the human forearm by Cobelli, C, Saccomani, M P, Ferrannini, E, Defronzo, R A, Gelfand, R, Bonadonna, R

“…Glucose transport is a critical step in the control of glucose disposal that, until presently, has not been quantitated in vivo in humans. We have employed the…”
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Glucose transport in human skeletal muscle : the in vivo response to insulin by BONADONNA, R. C, SACCOMANI, M. P, SEELY, L, ZYCH, K. S, FERRANNINI, E, COBELLI, C, DEFRONZO, R. A

“…Transmembrane glucose transport plays a key role in determining insulin sensitivity. We have measured in vivo WBGU, FGU, and K(in) and K(out) of…”
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Accessible Pool and System Parameters: Assumptions and Models by Cobelli, Claudio, Saccomani, Maria Pia

“…Quantitative assessment of substrate metabolism from in vivo tracer kinetic data requires a model of the system, i.e., a hypothesis on the structure and…”
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Transmembrane glucose transport in skeletal muscle of patients with non-insulin-dependent diabetes by BONADONNA, R. C, DEL PRATO, S, PIA SACCOMANI, M, BONORA, E, GULLI, G, FERRANNINI, E, BIER, D, COBELLI, C, DEFRONZO, R. A

“…Insulin resistance for glucose metabolism in skeletal muscle is a key feature in non-insulin-dependent diabetes mellitus (NIDDM). Which cellular effectors of…”
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Roles of glucose transport and glucose phosphorylation in muscle insulin resistance of NIDDM by BONADONNA, R. C, DEL PRATO, S, COBELLI, C, DEFRONZO, R. A, BONORA, E, SACCOMANI, M. P, GULLI, G, NATALI, A, FRASCERRA, S, PECORI, N, FERRANNINI, E, BIER, D

“…Insulin resistance for glucose metabolism in skeletal muscle is a key feature in NIDDM. The quantitative role of the cellular effectors of glucose metabolism…”
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Glucose transport in human skeletal muscle. The in vivo response to insulin by Bonadonna, R. C., Saccomani, M. P., Seely, L., Zych, K. S., Ferrannini, E., Cobelli, C., DeFronzo, R. A.

“…Glucose transport in human skeletal muscle. The in vivo response to insulin. R C Bonadonna , M P Saccomani , L Seely , K S Zych , E Ferrannini , C Cobelli and…”
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Parameter identifiability of nonlinear systems: the role of initial conditions by Pia Saccomani, Maria, Audoly, Stefania, D'Angiò, Leontina

“…Identifiability is a fundamental prerequisite for model identification; it concerns uniqueness of the model parameters determined from the input–output data,…”
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Domain of validity of classical models of leucine metabolism assessed by compartmental modeling by Cobelli, C, Saccomani, M P

“…Whole-body modeling of in vivo leucine (an essential amino acid) metabolism is fundamentally difficult due to the complexity of the system. This has favored…”
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