Search Results - "Sacco, Randy"

The Immunology of Bovine Respiratory Disease: Recent Advancements by McGill, Jodi L, Sacco, Randy E

“…Bovine respiratory disease (BRD) remains a leading cause of morbidity, mortality, and economic loss to the cattle industry. The continued high prevalence of…”
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Bovine Gamma Delta T Cells Contribute to Exacerbated IL-17 Production in Response to Co-Infection with Bovine RSV and Mannheimia haemolytica by McGill, Jodi L, Rusk, Rachel A, Guerra-Maupome, Mariana, Briggs, Robert E, Sacco, Randy E

“…Human respiratory syncytial virus (HRSV) is a leading cause of severe lower respiratory tract infection in children under five years of age. IL-17 and Th17…”
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An update on the development of a bottlenose dolphin, Tursiops truncatus, immune reagent toolkit by Sacco, Randy.E., Jensen, Eric D., Sullivan, Yvonne B., LaBresh, Joanna, Davis, William C.

“…There are extensive immunological reagents available for laboratory rodents and humans. However, for veterinary species there is a need for expansion of…”
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Vitamin A deficiency impairs the immune response to intranasal vaccination and RSV infection in neonatal calves by McGill, Jodi L., Kelly, Sean M., Guerra-Maupome, Mariana, Winkley, Emma, Henningson, Jamie, Narasimhan, Balaji, Sacco, Randy E.

“…Respiratory syncytial virus (RSV) infection is a leading cause of severe acute lower respiratory tract infection in infants and children worldwide. Vitamin A…”
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Ex vivo activated CD4+ T cells from young calves exhibit Th2-biased effector function with distinct metabolic reprogramming compared to adult cows by Eder, Jordan M., Sacco, Randy E.

“…As maternal passive immunity wanes at 6–8 weeks, young calves must rely on their own naïve and developing immune system for protection against pathogens…”
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Efficacy of mucosal polyanhydride nanovaccine against respiratory syncytial virus infection in the neonatal calf by McGill, Jodi L., Kelly, Sean M., Kumar, Pankaj, Speckhart, Savannah, Haughney, Shannon L., Henningson, Jamie, Narasimhan, Balaji, Sacco, Randy E.

“…Human respiratory syncytial virus (HRSV) is a leading cause of severe acute lower respiratory tract infection in infants and children worldwide. Bovine RSV…”
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Bovine milk exosome proteome by Reinhardt, Timothy A., Lippolis, John D., Nonnecke, Brian J., Sacco, Randy E.

“…Exosomes are 40–100nm membrane vesicles of endocytic origin, secreted by cells and are found in biological fluids including milk. These exosomes are…”
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Antimicrobial activity of bovine NK-lysin-derived peptides on bovine respiratory pathogen Histophilus somni by Dassanayake, Rohana P, Falkenberg, Shollie M, Briggs, Robert E, Tatum, Fred M, Sacco, Randy E

“…Bovine NK-lysins, which are functionally and structurally similar to human granulysin and porcine NK-lysin, are predominantly found in the granules of…”
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Bovine Viral Diarrhea Virus Type 2 Impairs Macrophage Responsiveness to Toll-Like Receptor Ligation with the Exception of Toll-Like Receptor 7 by Schaut, Robert G, Ridpath, Julia F, Sacco, Randy E

“…Bovine viral diarrhea virus (BVDV) is a member of the Flaviviridae family. BVDV isolates are classified into two biotypes based on the development of…”
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Development and testing of species-specific ELISA assays to measure IFN-γ and TNF-α in bottlenose dolphins (Tursiops truncatus) by Eberle, Kirsten C, Venn-Watson, Stephanie K, Jensen, Eric D, LaBresh, Joanna, Sullivan, Yvonne, Kakach, Laura, Sacco, Randy E

“…Monitoring the immune status of cetaceans is important for a variety of health conditions. Assays to quantify cytokines, especially pro-inflammatory cytokines,…”
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Oxidative stress pathway gene transcription after bovine respiratory syncytial virus infection in vitro and ex vivo by Hofstetter, Amelia R., Sacco, Randy E.

“…Studies in mouse and lamb models indicate important roles of reactive oxygen species (ROS) in the pathology and immune response to respiratory syncytial virus…”
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An intranasal recombinant NDV-BRSV Fopt vaccine is safe and reduces lesion severity in a colostrum-deprived calf model of RSV infection by Sacco, Randy E., Mena, Ignacio, Palmer, Mitchell V., Durbin, Russell K., García-Sastre, Adolfo, Durbin, Joan E.

“…Human respiratory syncytial virus (HRSV) is a major cause of severe lower respiratory tract disease in infants and the elderly, yet no safe, effective vaccine…”
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Vitamin D status of dairy cattle: Outcomes of current practices in the dairy industry by Nelson, Corwin D, Lippolis, John D, Reinhardt, Timothy A, Sacco, Randy E, Powell, Jessi L, Drewnoski, Mary E, O'Neil, Matthew, Beitz, Donald C, Weiss, William P

“…The need for vitamin D supplementation of dairy cattle has been known for the better part of the last century and is well appreciated by dairy producers and…”
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Monitoring bottlenose dolphin leukocyte cytokine mRNA responsiveness by qPCR by Hofstetter, Amelia Ruth, Eberle, Kirsten C, Venn-Watson, Stephanie K, Jensen, Eric D, Porter, Tracy J, Waters, Theresa E, Sacco, Randy E

“…Both veterinarians caring for dolphins in managed populations and researchers monitoring wild populations use blood-based diagnostics to monitor bottlenose…”
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SERUM IGG IMMUNOGLOBULIN LEVELS ARE ASSOCIATED WITH REDUCED PCR DETECTION OF MYCOPLASMA BOVIS IN NATURALLY INFECTED AMERICAN BISON (BISON BISON) by Kaplan, Bryan S., Malmberg, Jennifer L., Sondgeroth, Kerry S., Davila, Kaitlyn Sarlo, Dassanayake, Rohana P., Sacco, Randy E., Casas, Eduardo, Buttke, Danielle E.

“…Mycoplasma bovis (M. bovis) is an important pathogen of American bison (Bison bison), associated with high morbidity and mortality epizootics of respiratory…”
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An intranasal recombinant NDV-BRSV F opt vaccine is safe and reduces lesion severity in a colostrum-deprived calf model of RSV infection by Sacco, Randy E, Mena, Ignacio, Palmer, Mitchell V, Durbin, Russell K, García-Sastre, Adolfo, Durbin, Joan E

“…Human respiratory syncytial virus (HRSV) is a major cause of severe lower respiratory tract disease in infants and the elderly, yet no safe, effective vaccine…”
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Immunization with a mucosal, post-fusion F/G protein-based polyanhydride nanovaccine protects neonatal calves against BRSV infection by Maina, Teresia W, Grego, Elizabeth A, Broderick, Scott, Sacco, Randy E, Narasimhan, Balaji, McGill, Jodi L

“…Human respiratory syncytial virus (HRSV) is a leading cause of death in young children and there are no FDA approved vaccines. Bovine RSV (BRSV) is…”
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Identification of a DRB3011:01-restricted CD4 + T cell response against bovine respiratory syncytial virus fusion protein by Kaplan, Bryan S, Hofstetter, Amelia R, McGill, Jodi L, Lippolis, John D, Norimine, Junzo, Dassanayake, Rohana P, Sacco, Randy E

“…Although Human Respiratory Syncytial Virus (HRSV) is a significant cause of severe respiratory disease with high morbidity and mortality in pediatric and…”
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Parainfluenza Virus 3 Blocks Antiviral Mediators Downstream of the Interferon Lambda Receptor by Modulating Stat1 Phosphorylation by Eberle, Kirsten C, McGill, Jodi L, Reinhardt, Timothy A, Sacco, Randy E

“…Parainfluenza viruses are known to inhibit type I interferon (IFN) production; however, there is a lack of information regarding the type III IFN response…”
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Antiviral activity of bovine type III interferon against bovine viral diarrhea virus is greatly reduced in bovine turbinate cells due to limited expression of IFN lambda receptor 1 (IL-28Rα) by Dassanayake, Rohana P, Menghwar, Harish, Bickel, Kathryn A, Holthausen, David J, Ma, Hao, Diaz-San Segunda, Fayna, Rodriguez-Calzada, Monica, Medina, Gisselle N, Attreed, Sarah, Falkenberg, Shollie M, Kanipe, Carly, Sacco, Randy E, De Los Santos, Teresa, Casas, Eduardo

“…The antiviral activity of recombinant bovine interferon lambda 3 (bovIFN-λ3) against bovine viral diarrhea virus (BVDV) has been demonstrated in Madin-Darby…”
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