A genetic and epidemiologic study of cardiovascular disease in Alaska natives (GOCADAN): design and methods

A genetic and epidemiologic study of cardiovascular disease in Alaska natives (GOCADAN): design and methods

This article is a report of the design and methods of the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study. This longitudinal, population-based study was initiated to investigate the genetic determinants of cardiovascular disease and its risk factors. Between October 2000 and Ap...

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Bibliographic Details
Published in:International journal of circumpolar health Vol. 64; no. 3; pp. 206 - 221
Main Authors: Howard, Barbara V., Devereux, Richard D., Cole, Shelley A., Davidson, Michael, Dyke, Bennett, Ebbesson, Sven O. E., Epstein, Stephen E., Robinson, David R., Jarvis, Betty, Kaufman, David J., Laston, Sandra, MacCluer, Jean W., Okin, Peter M., Roman, Mary J., Romenesko, Terry, Ruotolo, Giacomo, Swenson, Michael, Wenger, Charlotte R., Williams-Blangero, Sarah, Zhu, Jianhui, Saccheus, Clarence, Fabsitz, Richard R., Robbins, David C.
Format: Journal Article
Language:English
Published: United States Taylor & Francis 01-07-2005
Subjects:
Adult
Aged
Alaska - epidemiology
Cardiovascular Diseases - ethnology
Cardiovascular Diseases - genetics
diabetes
Epidemiologic Research Design
epidemiology
Female
Genetic Predisposition to Disease - ethnology
genetics
Genotype
heart disease
Humans
Hypertension
Inflammation Mediators - blood
Inuit Eskimo
Inuits
Life Style - ethnology
Longitudinal Studies
Male
Middle Aged
Pedigree
Population Surveillance - methods
Risk Factors
vascular disease
Alaska
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Summary:This article is a report of the design and methods of the Genetics of Coronary Artery Disease in Alaska Natives (GOCADAN) Study. This longitudinal, population-based study was initiated to investigate the genetic determinants of cardiovascular disease and its risk factors. Between October 2000 and April 2004, this family study enrolled 1,214 Eskimos from several coastal villages in the Norton Sound region of Western Alaska. Examinations included a physical, laboratory determinations, and measures of subclinical disease. This study will generate a genome-wide scan for loci influencing cardiovascular disease-related traits. Relations between subclinical atherosclerosis and markers of inflammation will be examined using historic and newly drawn samples. The study will provide data on CVD prevalence, risk factors and the relative contribution of genetic and environmental determinants in Alaska Native peoples. Data from this study will contribute to the delivery of health-care and prevention of CVD in Alaska Eskimos and other populations. (Int J Circumpolar Health 2005; 64(3):206-221)
Bibliography:ObjectType-Article-1
SourceType-Scholarly Journals-1
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ISSN:1239-9736
2242-3982
2242-3982
DOI:10.3402/ijch.v64i3.17985