Search Results - "Sabroe, I"

CT features of pulmonary arterial hypertension and its major subtypes: a systematic CT evaluation of 292 patients from the ASPIRE Registry by Rajaram, S, Swift, A J, Condliffe, R, Johns, C, Elliot, C A, Hill, C, Davies, C, Hurdman, J, Sabroe, I, Wild, J M, Kiely, D G

“…We evaluated the prevalence and prognostic value of CT-pulmonary angiographic (CTPA) measures in 292 treatment naive patients with pulmonary arterial…”
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ASPIRE registry: Assessing the Spectrum of Pulmonary hypertension Identified at a REferral centre by HURDMAN, J, CONDLIFFE, R, BILLINGS, C, LAWRIE, A, SABROE, I, AKIL, M, O'TOOLE, L, KIELY, D. G, ELLIOT, C. A, DAVIES, C, HILL, C, WILD, J. M, CAPENER, D, SEPHTON, P, HAMILTON, N, ARMSTRONG, I. J

“…Pulmonary hypertension (PH) is a heterogeneous condition. To date, no registry data exists reflecting the spectrum of disease across the five diagnostic groups…”
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The role of TLR activation in inflammation by Sabroe, I, Parker, LC, Dower, SK, Whyte, MKB

“…The Toll‐like receptor family was originally identified in Drosophila, where it provides important developmental and immunological signalling. In mammals, the…”
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Translational Mini-Review Series on Toll-like Receptors: Networks regulated by Toll-like receptors mediate innate and adaptive immunity by Parker, L.C, Prince, L.R, Sabroe, I

“…The Toll-like receptor (TLR) family provide key components of mammalian immunity and are part of the earliest surveillance mechanisms responding to infection…”
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Rhinoviral infection and asthma: the detection and management of rhinoviruses by airway epithelial cells by Parker, L. C., Stokes, C. A., Sabroe, I.

“…Summary Human rhinoviruses (HRV) have been linked to the development of childhood asthma and recurrent acute asthma exacerbations throughout life, and…”
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Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes by Stokes, C A, Kaur, R, Edwards, M R, Mondhe, M, Robinson, D, Prestwich, E C, Hume, R D, Marshall, C A, Perrie, Y, O'Donnell, V B, Harwood, J L, Sabroe, I, Parker, L C

“…Human rhinovirus (HRV) infections are major contributors to the healthcare burden associated with acute exacerbations of chronic airway disease, such as…”
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Monocyte and macrophage dysfunction as a cause of HIV-1 induced dysfunction of innate immunity by Collini, P, Noursadeghi, M, Sabroe, I, Miller, R F, Dockrell, D H

“…HIV-1 can establish both long lived and productive infection of macrophages (Mϕ) but circulating monocytes are less permissive to infection. Multiple studies…”
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Diesel exhaust particles override natural injury-limiting pathways in the lung by Chaudhuri, N, Paiva, C, Donaldson, K, Duffin, R, Parker, L C, Sabroe, I

“…Induction of effective inflammation in the lung in response to environmental and microbial stimuli is dependent on cooperative signaling between leukocytes and…”
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Toll-like receptor (TLR)-based networks regulate neutrophilic inflammation in respiratory disease by Sabroe, I, Whyte, M K B

“…The neutrophil is a crucial early defence against microbial infection, but neutrophilic inflammation can result in devastating acute and chronic inflammatory…”
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rise and rise of Staphylococcus aureus: laughing in the face of granulocytes by Anwar, S, Prince, L.R, Foster, S.J, Whyte, M.K.B, Sabroe, I

“…Recent developments in the study of host-pathogen interactions have fundamentally altered our understanding of the nature of Staphylococcus aureus infection,…”
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Erratum: Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes by Stokes, C A, Kaur, R, Edwards, M R, Mondhe, M, Robinson, D, Prestwich, E C, Hume, R D, Marshall, C A, Perrie, Y, O'Donnell, V B, Harwood, J L, Sabroe, I, Parker, L C

“…Correction to: Mucosal Immunology (2016) 9, 1303–1316; doi:erratum10.1038/mi.2015.137 This article was originally published under CC BY-NC-SA 4.0 license, but…”
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Central venous catheter-related blood stream infections in patients receiving intravenous iloprost for pulmonary hypertension by Sammut, D., Elliot, C. A., Kiely, D. G., Armstrong, I. J., Martin, L., Wilkinson, J., Sephton, P., Jones, J., Hamilton, N., Hurdman, J., McLellan, E., Sabroe, I., Condliffe, R.

“…Catheter-related blood stream infection (CR-BSI) in patients with pulmonary hypertension (PH) receiving intravenous iloprost via an indwelling central line has…”
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Human rhinovirus-induced inflammatory responses are inhibited by phosphatidylserine containing liposomes by Stokes, C A, Kaur, R, Edwards, M R, Mondhe, M, Robinson, D, Prestwich, E C, Hume, R D, Marshall, C A, Perrie, Y, O'Donnell, V B, Harwood, J L, Sabroe, I, Parker, L C

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Muckle-Wells syndrome without mutation in exon 3 of the NLRP3 gene, identified by evidence of excessive monocyte production of functional interleukin 1β and rapid response to anakinra by Sabroe, R. A., Stokes, C. A., Parker, L. C., Higgins, K., Prince, L. R., Sabroe, I.

“…Summary We report a man with lifelong urticaria, night sweats, arthralgia and lethargy. He had high levels of inflammatory markers and serum amyloid A, but no…”
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Translational Mini‐Review Series on Immunology of Vascular Disease: Inflammation, infections and Toll‐like receptors in cardiovascular disease by Ward, J. R., Wilson, H. L., Francis, S. E., Crossman, D. C., Sabroe, I.

“…Summary Cardiovascular disease, in which atherosclerosis is the major underlying cause, is currently the largest cause of death in the world. Atherosclerosis…”
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Elevated CCR6+ CD4+ T lymphocytes in tissue compared with blood and induction of CCL20 during the asthmatic late response by Francis, J. N., Sabroe, I., Lloyd, C. M., Durham, S. R., Till, S. J.

“…Summary CCR6 is expressed by multiple leucocyte subsets, including peripheral blood memory T cells, and mouse models implicate a role for this receptor in…”
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T lymphocytes expressing CCR3 are increased in allergic rhinitis compared with non‐allergic controls and following allergen immunotherapy by Francis, J. N., Lloyd, C. M., Sabroe, I., Durham, S. R., Till, S. J.

“…Background:  In T cell‐associated allergic inflammation, homing of T‐helper 2 (Th2) effector cells to mucosal sites may be influenced by chemokine receptor…”
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Chemokines, innate and adaptive immunity, and respiratory disease by Sabroe, I, Lloyd, C.M, Whyte, M.K.B, Dower, S.K, Williams, T.J, Pease, J.E

“…Selective leukocyte trafficking and recruitment is primarily regulated by a specific family of small proteins called "chemokines". This extended family…”
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Eotaxin Is Specifically Cleaved by Hookworm Metalloproteases Preventing Its Action In Vitro and In Vivo by Culley, Fiona J, Brown, Alan, Conroy, Dolores M, Sabroe, Ian, Pritchard, David I, Williams, Timothy J

“…Eotaxin is a potent eosinophil chemoattractant that acts selectively through CCR3, which is expressed on eosinophils, basophils, mast cells, and Th2-type T…”
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Toll-like receptors: their role in allergy and non-allergic inflammatory disease by Sabroe, I., Parker, L. C., Wilson, A. G., Whyte, M. K. B., Dower, S. K.

“…Summary The human TLRs comprise an important and interesting group of receptors that regulate pathogen‐related responses, and play as yet uncharacterized roles…”
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