Salivary metabolomics in oral potentially malignant disorders and oral cancer patients—a systematic review with meta-analysis

Salivary metabolomics in oral potentially malignant disorders and oral cancer patients—a systematic review with meta-analysis

Objectives The aim of this systematic review and meta-analysis is to assess the diagnostic potential of salivary metabolomics in the detection of oral potentially malignant disorders (OPMDs) and oral cancer (OC). Materials and methods A systematic review was performed in accordance with the 3rd edit...

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Published in:Clinical oral investigations Vol. 28; no. 1; p. 98
Main Authors: Nazar, Nur Syahirah Binti Mohd, Ramanathan, Anand, Ghani, Wan Maria Nabillah, Rokhani, Faezah Binti, Jacob, Pulikkotil Shaju, Sabri, Nurul Elma Binti, Hassan, Mohd Sukri, Kadir, Kathreena, Dharmarajan, Lalli
Format: Journal Article
Language:English
Published: Berlin/Heidelberg Springer Berlin Heidelberg 16-01-2024
Springer Nature B.V
Subjects:
Acetylglucosamine
Biomarkers
Dental health
Dentistry
Diagnostic tests
Humans
Medicine
Meta-analysis
Metabolites
Metabolomics
Mouth Diseases
Mouth Neoplasms - pathology
N-Acetylglucosamine
Oral cancer
Precancerous Conditions - pathology
Quality control
Reproducibility of Results
Review
Systematic review
Systematic review
Oral cancer
Salivary metabolomics
OPMD
Meta-analysis
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Summary:Objectives The aim of this systematic review and meta-analysis is to assess the diagnostic potential of salivary metabolomics in the detection of oral potentially malignant disorders (OPMDs) and oral cancer (OC). Materials and methods A systematic review was performed in accordance with the 3rd edition of the Centre for Reviews and Dissemination (CRD) and Preferred Reporting Items for Systematic Reviews and Meta-analyses (PRISMA) statement. Electronic searches for articles were carried out in the PubMed, Web of Science, and Scopus databases. The quality assessment of the included studies was evaluated using the Newcastle-Ottawa Quality Assessment Scale (NOS) and the new version of the QUADOMICS tool. Meta-analysis was conducted whenever possible. The effect size was presented using the Forest plot, whereas the presence of publication bias was examined through Begg’s funnel plot. Results A total of nine studies were included in the systematic review. The metabolite profiling was heterogeneous across all the studies. The expression of several salivary metabolites was found to be significantly altered in OPMDs and OCs as compared to healthy controls. Meta-analysis was able to be conducted only for N-acetylglucosamine. There was no significant difference (SMD = 0.15; 95% CI − 0.25–0.56) in the level of N-acetylglucosamine between OPMDs, OC, and the control group. Conclusion Evidence for N-acetylglucosamine as a salivary biomarker for oral cancer is lacking. Although several salivary metabolites show changes between healthy, OPMDs, and OC, their diagnostic potential cannot be assessed in this review due to a lack of data. Therefore, further high-quality studies with detailed analysis and reporting are required to establish the diagnostic potential of the salivary metabolites in OPMDs and OC. Clinical relevance While some salivary metabolites exhibit significant changes in oral potentially malignant disorders (OPMDs) and oral cancer (OC) compared to healthy controls, the current evidence, especially for N-acetylglucosamine, is inadequate to confirm their reliability as diagnostic biomarkers. Additional high-quality studies are needed for a more conclusive assessment of salivary metabolites in oral disease diagnosis.
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ISSN:1436-3771
1432-6981
1436-3771
DOI:10.1007/s00784-023-05481-6