Search Results - "Sabourin, Valérie"

STAT1 potentiates oxidative stress revealing a targetable vulnerability that increases phenformin efficacy in breast cancer by Totten, Stephanie P., Im, Young Kyuen, Cepeda Cañedo, Eduardo, Najyb, Ouafa, Nguyen, Alice, Hébert, Steven, Ahn, Ryuhjin, Lewis, Kyle, Lebeau, Benjamin, La Selva, Rachel, Sabourin, Valérie, Martínez, Constanza, Savage, Paul, Kuasne, Hellen, Avizonis, Daina, Santos Martínez, Nancy, Chabot, Catherine, Aguilar-Mahecha, Adriana, Goulet, Marie-Line, Dankner, Matthew, Witcher, Michael, Petrecca, Kevin, Basik, Mark, Pollak, Michael, Topisirovic, Ivan, Lin, Rongtuan, Siegel, Peter M., Kleinman, Claudia L., Park, Morag, St-Pierre, Julie, Ursini-Siegel, Josie

“…Bioenergetic perturbations driving neoplastic growth increase the production of reactive oxygen species (ROS), requiring a compensatory increase in ROS…”
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The Shc1 adaptor simultaneously balances Stat1 and Stat3 activity to promote breast cancer immune suppression by Ahn, Ryuhjin, Sabourin, Valérie, Bolt, Alicia M., Hébert, Steven, Totten, Stephanie, De Jay, Nicolas, Festa, Maria Carolina, Young, Yoon Kow, Im, Young Kyuen, Pawson, Tony, Koromilas, Antonis E., Muller, William J., Mann, Koren K., Kleinman, Claudia L., Ursini-Siegel, Josie

“…Tyrosine kinase signalling within cancer cells is central to the establishment of an immunosuppressive microenvironment. Although tyrosine kinase inhibitors…”
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p66ShcA promotes malignant breast cancer phenotypes by alleviating energetic and oxidative stress by Lewis, Kyle, La Selva, Rachel, Maldonado, Elias, Annis, Matthew G., Najyb, Ouafa, Cepeda Cañedo, Eduardo, Totten, Stephanie, Hébert, Steven, Sabourin, Valérie, Mirabelli, Caitlynn, Ciccolini, Emma, Lehuédé, Camille, Choinière, Luc, Russo, Mariana, Avizonis, Daina, Park, Morag, St-Pierre, Julie, Kleinman, Claudia L., Siegel, Peter M., Ursini-Siegel, Josie

“…Significant efforts have focused on identifying targetable genetic drivers that support the growth of solid tumors and/or increase metastatic ability. During…”
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Tungsten targets the tumor microenvironment to enhance breast cancer metastasis by Bolt, Alicia M, Sabourin, Valérie, Molina, Manuel Flores, Police, Alice M, Negro Silva, Luis Fernando, Plourde, Dany, Lemaire, Maryse, Ursini-Siegel, Josie, Mann, Koren K

“…The number of individuals exposed to high levels of tungsten is increasing, yet there is limited knowledge of the potential human health risks. Recently, a…”
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p66ShcA functions as a contextual promoter of breast cancer metastasis by Lewis, Kyle, Kiepas, Alex, Hudson, Jesse, Senecal, Julien, Ha, Jacqueline R, Voorand, Elena, Annis, Matthew G, Sabourin, Valerie, Ahn, Ryuhjin, La Selva, Rachel, Tabariès, Sébastien, Hsu, Brian E, Siegel, Matthew J, Dankner, Matthew, Canedo, Eduardo Cepeda, Lajoie, Mathieu, Watson, Ian R, Brown, Claire M, Siegel, Peter M, Ursini-Siegel, Josie

“…The p66ShcA redox protein is the longest isoform of the Shc1 gene and is variably expressed in breast cancers. In response to a variety of stress stimuli,…”
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Metastatic breast cancer cells are metabolically reprogrammed to maintain redox homeostasis during metastasis by Biondini, Marco, Lehuédé, Camille, Tabariès, Sébastien, Annis, Matthew G., Pacis, Alain, Ma, Eric H., Tam, Christine, Hsu, Brian E., Audet-Delage, Yannick, Abu-Thuraia, Afnan, Girondel, Charlotte, Sabourin, Valerie, Totten, Stephanie P., de Sá Tavares Russo, Mariana, Bridon, Gaëlle, Avizonis, Daina, Guiot, Marie-Christine, St-Pierre, Julie, Ursini-Siegel, Josie, Jones, Russell, Siegel, Peter M.

“…Metabolic rewiring is essential for tumor growth and progression to metastatic disease, yet little is known regarding how cancer cells modify their acquired…”
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The ShcA PTB Domain Functions as a Biological Sensor of Phosphotyrosine Signaling during Breast Cancer Progression by AHN, Ryuhjin, SABOURIN, Valerie, SIEGEL, Peter M, PAWSON, Tony, URSINI-SIEGEL, Josie, HA, Jacqueline R, CORY, Sean, MARIC, Gordana, YOUNG KYUEN IM, HARDY, W. Rod, HONG ZHAO, PARK, Morag, HALLETT, Michael

“…ShcA (SHC1) is an adapter protein that possesses an SH2 and a PTB phosphotyrosine-binding motif. ShcA generally uses its PTB domain to engage activated…”
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Abstract 21: p66ShcA is a contextual breast cancer metastasis promoter or suppressor depending on the tumor microenvironment by Hudson, Jesse, Lewis, Kyle, Senécal, Julien, Kiepas, Alexander, Tabariès, Sébastien, Sabourin, Valérie, Ahn, Ryuhjin, Selva, Rachel La, Siegel, Peter, Ursini-Siegel, Giuseppina

“…Abstract Introduction: Src homology and collagen A (ShcA) adaptor proteins are essential during breast cancer progression. However, the role of the largest…”
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Abstract 1279: Investigating the impact of PGC-1α-coupled metabolic reprogramming on breast cancer metastasis by Ciccolini, Emma, Sabourin, Valérie, Patten, David, Im, Young K., Hébert, Steven, Muller, William J., Kleinman, Claudia, St-Pierre, Julie, Ursini-Siegel, Josie

“…Abstract Peroxisome proliferator-activated receptor γ coactivator 1 α (PGC-1α) is a transcriptional coactivator known to play a role in regulating cellular…”
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The Neurodevelopmental Protein POGZ Suppresses Metastasis in Triple Negative Breast Cancer by Attenuating TGFβ Signaling by Heath, John, Mirabelli, Caitlynn, Annis, Matthew G, Sabourin, Valerie, Hébert, Steven, Findlay, Steven, Kim, HaEun, Witcher, Michael, Kleinman, Claudia L, Siegel, Peter M, Orthwein, Alexandre, Ursini-Siegel, Josie

“…The pogo transposable element derived zinc finger protein, POGZ, is notably associated with neurodevelopmental disorders through its role in gene…”
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A second-generation eIF4A RNA helicase inhibitor exploits translational reprogramming as a vulnerability in triple-negative breast cancer by Cencic, Regina, Im, Young K, Naineni, Sai Kiran, Moustafa-Kamal, Mohamed, Jovanovic, Predrag, Sabourin, Valerie, Annis, Matthew G, Robert, Francis, Schmeing, T Martin, Koromilas, Antonis, Paquet, Marilène, Teodoro, Jose G, Huang, Sidong, Siegel, Peter M, Topisirovic, Ivan, Ursini-Siegel, Josie, Pelletier, Jerry

“…In this study, we aimed to address the current limitations of therapies for macro-metastatic triple-negative breast cancer (TNBC) and provide a therapeutic…”
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Interplay between ShcA Signaling and PGC-1α Triggers Targetable Metabolic Vulnerabilities in Breast Cancer by Im, Young Kyuen, Najyb, Ouafa, Gravel, Simon-Pierre, McGuirk, Shawn, Ahn, Ryuhjin, Avizonis, Daina Z, Chénard, Valérie, Sabourin, Valerie, Hudson, Jesse, Pawson, Tony, Topisirovic, Ivan, Pollak, Michael, St-Pierre, Julie, Ursini-Siegel, Josie

“…The ShcA adaptor protein transduces oncogenic signals downstream of receptor tyrosine kinases. We show here that breast tumors engage the ShcA pathway to…”
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Abstract 322: Distinct pools of ShcA coupled tyrosine kinase signaling influences breast tumor heterogeneity and therapeutic responsiveness by Ha, Jacqueline R., Ahn, Ryuhjin, Im, Young Kyuen, Sabourin, Valerie, Smith, Harvey W., Topisirovic, Ivan, Pawson, Tony, Siegel, Peter, Muller, William J., Ursini-Siegel, Josie

“…Abstract Phospho-tyrosine (pTyr) signaling networks are frequently activated in breast cancers (BrCa) and are considered to be major oncogenic drivers of tumor…”
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p66ShcA Promotes Breast Cancer Plasticity by Inducing an Epithelial-to-Mesenchymal Transition by Hudson, Jesse, Ha, Jacqueline R., Sabourin, Valerie, Ahn, Ryuhjin, La Selva, Rachel, Livingstone, Julie, Podmore, Lauren, Knight, Jennifer, Forrest, Laura, Beauchemin, Nicole, Hallett, Michael, Park, Morag, Ursini-Siegel, Josie

“…Breast cancers are stratified into distinct subtypes, which influence therapeutic responsiveness and patient outcome. Patients with luminal breast cancers are…”
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Integration of Distinct ShcA Signaling Complexes Promotes Breast Tumor Growth and Tyrosine Kinase Inhibitor Resistance by Ha, Jacqueline R, Ahn, Ryuhjin, Smith, Harvey W, Sabourin, Valerie, Hébert, Steven, Cepeda Cañedo, Eduardo, Im, Young Kyuen, Kleinman, Claudia L, Muller, William J, Ursini-Siegel, Josie

“…The commonality between most phospho-tyrosine signaling networks is their shared use of adaptor proteins to transduce mitogenic signals. ShcA ( ) is one such…”
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