Search Results - "Sabourin, P J"

Extrapulmonary tissue responses in cynomolgus macaques (Macaca fascicularis) infected with highly pathogenic avian influenza A (H5N1) virus by Tolnay, A.-E., Baskin, C. R., Tumpey, T. M., Sabourin, P. J., Sabourin, C. L., Long, J. P., Pyles, J. A., Albrecht, R. A., García-Sastre, A., Katze, M. G., Bielefeldt-Ohmann, H.

“…The mechanisms responsible for virulence of influenza viruses in humans remain poorly understood. A prevailing hypothesis is that the highly pathogenic virus…”
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Metabolism of thalidomide in human microsomes, cloned human cytochrome P-450 isozymes, and Hansen's disease patients by Teo, Steve K., Sabourin, P. J., O'Brien, K., Kook, K. A., Thomas, S. D.

“…Previous in vitro studies in rat microsomal preparations suggested that thalidomide is metabolized by the cytochrome P450 system (CYP). In this study, we…”
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A physiological model for simulation of benzene metabolism by rats and mice by Medinsky, M A, Sabourin, P J, Lucier, G, Birnbaum, L S, Henderson, R F

“…Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6C3F1 mice are more sensitive to the toxic effects of…”
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The Effect of Dose, Dose Rate, Route of Administration, and Species on Tissue and Blood Levels of Benzene Metabolites by Henderson, Rogene F., Sabourin, Patrick J., Bechtold, William E., Griffith, William C., Medinsky, Michele A., Birnbaum, Linda S., Lucier, George W.

“…Studies were completed in F344/N rats and B6 C3 F1mice to determine the effect of dose, dose rate, route of administration, and rodent species on formation of…”
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Disposition of inhaled isobutene in F344/N rats by Henderson, R F, Sabourin, P J, Bechtold, W E, Steinberg, B, Chang, I Y

“…Isobutene (2-methylpropene) (CAS No. 115-11-7) is a gas widely used in the chemical manufacturing industry. As an aid to planning long-term toxicity studies,…”
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Distribution of microsomal monooxygenases in the rabbit respiratory tract by Sabourin, P J, Tynes, R E, Philpot, R M, Winquist, S, Dahl, A R

“…The distribution of microsomal cytochrome P-450 isozymes 2, 4, 5, and 6 and the pulmonary FAD-containing monooxygenase was determined in 10 different…”
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Physiologically based modeling of 2-butoxyethanol disposition in rats following different routes of exposure by Shyr, L J, Sabourin, P J, Medinsky, M A, Birnbaum, L S, Henderson, R F

“…2-Butoxyethanol (BE) is widely used as a solvent in coatings and other consumer products and has shown hematotoxicity in laboratory animals. To provide a…”
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Effect of exposure concentration, exposure rate, and route of administration on metabolism of benzene by F344 rats and B6C3F1 mice by Sabourin, P J, Bechtold, W E, Griffith, W C, Birnbaum, L S, Lucier, G, Henderson, R F

“…To determine the effect of exposure concentration and the route of administration on benzene metabolism, male F344/N rats and B6C3F1 mice were orally exposed…”
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Differences in the metabolism and disposition of inhaled [3H]benzene by F344/N rats and B6C3F1 mice by Sabourin, P J, Bechtold, W E, Birnbaum, L S, Lucier, G, Henderson, R F

“…Benzene is a potent hematotoxin and has been shown to cause leukemia in man. Chronic toxicity studies indicate that B6C3F1 mice are more susceptible than…”
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Identification of distinct hepatic and pulmonary forms of microsomal flavin-containing monooxygenase in the mouse and rabbit by Tynes, R E, Sabourin, P J, Hodgson, E

“…The flavin-containing monooxygenase has been purified from mouse and rabbit lung microsomes and shown to be distinct from the flavin-containing monooxygenase…”
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Identification of Thiocyanate as the Principal Metabolite of Oxamyl in Lactating Goat by Li, Y, Barefoot, A. C, Reiser, R. W, Fogiel, A. J, Sabourin, P. J

“…The metabolic fate of [1-14C]oxamyl in a lactating goat was investigated. The test animal was administered five consecutive daily doses orally at 31 ppm oxamyl…”
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Purification and characterization of an alpha-ketoisocaproate oxygenase of rat liver by Sabourin, P J, Bieber, L L

“…Rat liver contains a cytosolic alpha-ketoisocaproate oxygenase which oxidatively decarboxylates and hydroxylates alpha-ketoisocaproate to form…”
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Differences in the Pathways for Metabolism of Benzene in Rats and Mice Simulated by a Physiological Model by Medinsky, Michele A., Sabourin, Patrick J., Henderson, Rogene F., Lucier, George, Birnbaum, Linda S.

“…Studies conducted by the National Toxicology Program on the chronic toxicity of benzene indicated that B6 C3 F1mice were more sensitive to the carcinogenic…”
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Effect of dose on the absorption and excretion of [14C]benzene administered orally or by inhalation in rats and mice by Sabourin, P J, Chen, B T, Lucier, G, Birnbaum, L S, Fisher, E, Henderson, R F

“…The effect of dose on the absorption and excretion of [14C]benzene was studied using 13-week old male F344/N rats, Sprague-Dawley rats, and B6C3F1 mice…”
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Metabolism of [14C]benzene by cynomolgus monkeys and chimpanzees by Sabourin, P J, Muggenburg, B A, Couch, R C, Lefler, D, Lucier, G, Birnbaum, L S, Henderson, R F

“…Rodent bioassays indicate that B6C3F1 mice are more sensitive to the carcinogenicity of benzene than are rats. The urinary profile of benzene metabolites is…”
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The mechanism of alpha-ketoisocaproate oxygenase. Formation of beta-hydroxyisovalerate from alpha-ketoisocaproate by Sabourin, P J, Bieber, L L

“…A soluble alpha-ketoisocaproate oxygenase from rat liver catalyzes the decarboxylation and hydroxylation of alpha-ketoisocaproate to form…”
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A high pressure liquid chromatographic method for the separation and quantitation of water-soluble radiolabeled benzene metabolites by Sabourin, P J, Bechtold, W E, Henderson, R F

“…The glucuronide and sulfate conjugates of benzene metabolites as well as muconic acid and pre-phenyl- and phenylmercapturic acids were separated by ion-pairing…”
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Toxicokinetics of inhaled 1,3-butadiene in monkeys: comparison to toxicokinetics in rats and mice by Dahl, A R, Sun, J D, Birnbaum, L S, Bond, J A, Griffith, Jr, W C, Mauderly, J L, Muggenburg, B A, Sabourin, P J, Henderson, R F

“…1,3-Butadiene is a potent carcinogen in mice and a weaker carcinogen in rats. People are exposed to butadiene through its industrial use--largely in rubber…”
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Effect of exposure concentration on the disposition of inhaled butoxyethanol by F344 rats by Sabourin, P J, Medinsky, M A, Birnbaum, L S, Griffith, W C, Henderson, R F

“…The glycol ethers are a class of solvents widely used due to their range of vapor pressures and miscibility in aqueous and organic media. Butoxyethanol (BE)…”
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Formation of hydrogen peroxide and N-hydroxylated amines catalyzed by pulmonary flavin-containing monooxygenases in the presence of primary alkylamines by Tynes, R E, Sabourin, P J, Hodgson, E, Philpot, R M

“…In atypical reaction, incubation of purified rabbit pulmonary flavin-containing monooxygenase with certain primary alkylamines results in the oxidation of…”
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