Search Results - "Sabo, Tibor J"
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In Vitro Anticancer Evaluation of Platinum(II/IV) Complexes with Diisoamyl Ester of (S,S)-ethylenediamine-N,N'-di-2-propanoic Acid
Published in Anti-cancer agents in medicinal chemistry (01-07-2017)“…Platinum(II) and platinum(IV) complexes [PtCln{(S,S)-(i-Am)2eddip}] (n = 2, 4: 1, 2, respectively; (S,S)-(i-Am)2eddip =…”
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Synthesis and in vitro Anticancer Activity of Octahedral Platinum(IV) Complexes with Cyclohexyl-Functionalized Ethylenediamine-N,N′-Diacetate-Type Ligands
Published in ChemMedChem (07-06-2010)“…The present study describes the synthesis and anticancer activity of novel octahedral PtIV complexes with cyclohexyl functionalized…”
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Prediction of in vivo Bioavailibility by in vitro Characterization of Ethylenediamine Dipropanoic Acid Derivatives with Cytotoxic Activity
Published in Acta chimica Slovenica (01-03-2018)“…O,O'-diethyl-(S,S)-ethylenediamine-N,N'-di-2-(3-cyclohexyl)propanoate (DE-EDCP) is novel substance with cytotoxic activity in human leukemic cells. The aim of…”
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Novel methylene bridged ethylenediamine-type ligands: Synthesis and spectral characterization
Published in Journal of the Serbian Chemical Society (01-01-2014)“…Herein we report the synthesis of two new organic compounds, diisobutyl- and diisopentyl…”
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Synthesis and high in vitro cytotoxicity of some (S,S)-ethylenediamine-N,N’-di-2-propanoate dihydrochloride esters
Published in Journal of the Serbian Chemical Society (01-01-2014)“…Novel (S,S)-R2eddip ester, O,O’-diisoamyl-(S,S)-ethylenediamine-N,N’-di-2-propanoate dihydrochloride, 1, was synthesized and characterized by IR, 1H and 13C…”
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In vitro anticancer activity of gold(III) complexes with some esters of (S,S)-ethylenediamine-N,N′-di-2-propanoic acid
Published in European journal of medicinal chemistry (27-01-2015)“…Five novel gold(III) complexes of general formulas [AuCl2{(S,S)-R2eddip}]PF6, ((S,S)-eddip = (S,S)-ethylenediamine-N,N′-di-2-propanoate, R = n-Bu, n-Pe, i-Bu,…”
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Synthesis, characterization and cytotoxic activity of novel platinum(II) iodido complexes
Published in European journal of medicinal chemistry (23-07-2014)“…Novel Pt(II) complexes of general formula [PtI2(L1−3)], (C1–C3): where L1−3 are isobutyl, n-pentyl and isopentyl esters of…”
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Antileukemic action of novel diamine Pt(II) halogenido complexes: Comparison of the representative novel Pt(II) with corresponding Pt(IV) complex
Published in Chemical biology & drug design (01-08-2017)“…This study presents the synthesis, characterization, and antitumor action of five new Pt(II) halogenido, chlorido, and iodido complexes with edda type of…”
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In vitro antitumor activity, metal uptake and reactivity with ascorbic acid and BSA of some gold(III) complexes with N,N′-ethylenediamine bidentate ester ligands
Published in Journal of inorganic biochemistry (01-07-2017)“…Four novel gold(III) complexes of general formulae [AuCl2{(S,S)-R2eddl}]PF6 (R2eddl=O,O′-dialkyl-(S,S)-ethylenediamine-N,N′-di-2-(4-methyl)pentanoate, R=n-Pr,…”
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Reactions of cytotoxic metallodrugs with lysozyme in pure DMSO explored through UV–Vis absorption spectroscopy and ESI MS
Published in Biometals (01-04-2015)“…The reactions of four representative metallodrugs with the model protein HEWL were investigated within a non-aqueous environment-i.e. in pure DMSO- through…”
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Gold(III) complexes with esters of cyclohexyl-functionalized ethylenediamine-N,N′-diacetate
Published in Journal of inorganic biochemistry (01-11-2013)“…Six novel gold(III) complexes containing O,O′-dialkyl-(S,S)-ethylenediamine-N,N′-di-2-(3-cyclohexyl)propanoate ([AuCl2{(S,S)-R2eddch}]PF6, R=Me, Et, n-Pr,…”
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Cytotoxic studies of substituted titanocene and ansa-titanocene anticancer drugs
Published in Journal of inorganic biochemistry (01-08-2008)“…A variety of substituted titanocene and ansa-titanocene complexes have been synthesized and characterized using traditional methods. The cytotoxic activity of…”
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Novel platinum(IV) complexes induce rapid tumor cell death in vitro
Published in International journal of cancer (01-09-2005)“…The anticancer activity of platinum complexes has been known since the discovery of classical Pt(II)‐based drug cisplatin. However, Pt(IV) complexes have…”
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In vitro and in vivo antimelanoma effect of ethyl ester cyclohexyl analog of ethylenediamine dipropanoic acid
Published in Melanoma research (01-02-2018)“…Melanoma, an aggressive skin tumor with high metastatic potential, is associated with high mortality and increasing morbidity. Multiple available…”
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Novel methylene modified cyclohexyl ethylenediamine-N,N′-diacetate ligands and their platinum(IV) complexes. Influence on biological activity
Published in Journal of inorganic biochemistry (01-04-2012)“…This paper focuses on the synthesis, characterization and biological activity of new N,N′-methylene modified cyclohexyl ethylenediamine-N,N′-diacetate…”
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Palladium(II) complexes with R(2)edda derived ligands. Part IV. O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: synthesis, characterization and in vitro antitumoral activity against chronic lymphocytic leukemia (CLL) cells
Published in European journal of medicinal chemistry (01-09-2010)“…Four novel bidentate N,N'-ligand precursors, including O,O'-dialkyl esters (alkyl = ethyl, n-propyl, n-butyl and n-pentyl), L1 x 2 HCl-L4 x 2 HCl, of…”
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Palladium(II) complexes with R2edda derived ligands. Part IV. O,O'-dialkyl esters of (S,S)-ethylenediamine-N,N'-di-2-(4-methyl)-pentanoic acid dihydrochloride and their palladium(II) complexes: Synthesis, characterization and in vitro antitumoral activity against chronic lymphocytic leukemia (CLL) cells
Published in European journal of medicinal chemistry (01-09-2010)Get full text
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Synthesis, characterization and ROS-mediated cytotoxic action of novel (S,S)-1,3-propanediamine-N,N′-di-2-(3-cyclohexyl)propanoic acid and corresponding esters
Published in Bioorganic chemistry (01-06-2014)“…[Display omitted] •Report of new cyclohexyl 1,3-propanediamine-N,N′-diacetate-type molecules.•Assessment of in vitro anticancer activity against different…”
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Synthesis and in vitro antitumoral activity of novel O,O′-di-2-alkyl-(S,S)-ethylenediamine-N,N′-di-2-propanoate ligands and corresponding platinum(II/IV) complexes
Published in Journal of inorganic biochemistry (01-04-2008)“…Syntheses of two novel ligand precursors O,O′-diisopropyl- (1a) and O,O′-diisobutyl-(S,S)-ethylenediamine-N,N′-di-2-propanoate dihydrochloride monohydrate (1b)…”
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Pyrolysis and Catalyzed Pyrolysis in the Investigation of a Neogene Shale Potential from Valjevo-Mionica Basin, Serbia
Published in Energy & fuels (19-08-2010)“…The generative potential of a Neogene shale from Valjevo-Mionica Basin (Serbia) was investigated using conventional pyrolysis and pyrolysis in the presence of…”
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