Search Results - "Sabir, Ian"

Current evidence for COVID-19 therapies: a systematic literature review by Welte, Tobias, Ambrose, Lucy J, Sibbring, Gillian C, Sheikh, Shehla, Müllerová, Hana, Sabir, Ian

“…Effective therapeutic interventions for the treatment and prevention of coronavirus disease 2019 (COVID-19) are urgently needed. A systematic review was…”
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Action potential wavelength restitution predicts alternans and arrhythmia in murine Scn5a+/− hearts by Matthews, Gareth D. K., Guzadhur, Laila, Sabir, Ian N., Grace, Andrew A., Huang, Christopher L.‐H.

“…Key points •  Mice which are haploinsufficient in the Scn5a+/− gene have reduced cardiac sodium channel (Nav1.5) density and are used to model the Brugada…”
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P194: Persistence of growth promoting effects in children with achondroplasia over seven years: Update from phase II extension study with vosoritide by Hoover-Fong, Julie, Irving, Melita, Bacino, Carlos, Charrow, Joel, Cormier-Daire, Valérie, Polgreen, Lynda, Harmatz, Paul, Huntsman-Labed, Alice, Fisheleva, Elena, Sabir, Ian, Day, Jonathan, Phillips, John, Savarirayan, Ravi

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Antithrombotic therapy in atrial fibrillation: aspirin is rarely the right choice by Sabir, Ian N, Matthews, Gareth D K, Huang, Christopher L-H

“…Atrial fibrillation, the commonest cardiac arrhythmia, predisposes to thrombus formation and consequently increases risk of ischaemic stroke. Recent years have…”
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An Alternative to Sodium Polystyrene Sulfonate and Patiromer for the Treatment of Hyperkalemia by Sabir, Ian

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Ventricular arrhythmogenesis: Insights from murine models by Sabir, Ian N., Killeen, Matthew J., Grace, Andrew A., Huang, Christopher L.-H.

“…Ventricular arrhythmias are the key underlying cause of sudden cardiac death, a common cause of mortality and a significant public health burden. Insights into…”
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The contribution of refractoriness to arrhythmic substrate in hypokalemic Langendorff-perfused murine hearts by Sabir, Ian N, Fraser, James A, Killeen, Matthew J, Grace, Andrew A, Huang, Christopher L-H

“…The clinical effects of hypokalemia including action potential prolongation and arrhythmogenicity suppressible by lidocaine were reproduced in hypokalemic (3.0…”
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Dispersions of repolarization and ventricular arrhythmogenesis: Lessons from animal models by Killeen, Matthew J., Sabir, Ian N., Grace, Andrew A., Huang, Christopher L.-H.

“…Sudden cardiac death resulting from ventricular arrhythmogenesis is a leading cause of mortality in the developed world, accounting for up to 400,000 deaths…”
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Sudden arrhythmic death: from basic science to clinical practice by Sabir, Ian N, Matthews, Gareth D K, Huang, Christopher L-H

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Restitution analysis of alternans and its relationship to arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts by Sabir, Ian N., Li, Lucia M., Grace, Andrew A., Huang, Christopher L.-H.

“…Alternans and arrhythmogenicity were studied in hypokalaemic (3.0 mM K + ) Langendorff-perfused murine hearts paced at high rates. Epicardial and endocardial…”
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Repolarization gradients and arrhythmogenicity in the murine heart by Killeen, Matthew J., Sabir, Ian N.

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Cardiac Arrhythmia: A Simple Conceptual Framework by Kalin, Asli, Usher-Smith, Juliet, Jones, Victoria J, Huang, Christopher L.-H, Sabir, Ian N

“…This review presents a simple trigger-substrate model of arrhythmogenesis and its application to the generation of reentrant ventricular arrhythmias. We…”
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Criteria for arrhythmogenicity in genetically-modified Langendorff-perfused murine hearts modelling the congenital long QT syndrome type 3 and the Brugada syndrome by Sabir, Ian N., Li, Lucia M., Jones, Victoria J., Goddard, Catharine A., Grace, Andrew A., Huang, Christopher L.-H.

“…The experiments investigated the applicability of two established criteria for arrhythmogenicity in Scn5a+/Δ and Scn5a+/− murine hearts modelling the…”
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Alternans in genetically modified langendorff-perfused murine hearts modeling catecholaminergic polymorphic ventricular tachycardia by Sabir, Ian N, Ma, Nan, Jones, Victoria J, Goddard, Catharine A, Zhang, Yanmin, Kalin, Asli, Grace, Andrew A, Huang, Christopher L-H

“…The relationship between alternans and arrhythmogenicity was studied in genetically modified murine hearts modeling catecholaminergic polymorphic ventricular…”
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Transient alterations in transmural repolarization gradients and arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts by Sabir, Ian N., Killeen, Matthew J., Goddard, Catharine A., Thomas, Glyn, Gray, Simon, Grace, Andrew A., Huang, Christopher L.‐H.

“…Clinical hypokalaemia is associated with acquired electrocardiographic QT prolongation and arrhythmic activity initiated by premature ventricular…”
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A quantitative analysis of the effect of cycle length on arrhythmogenicity in hypokalaemic Langendorff-perfused murine hearts by Sabir, Ian N, Fraser, James A, Cass, Thomas R, Grace, Andrew A, Huang, Christopher L-H

“…The clinically established proarrhythmic effect of bradycardia and antiarrhythmic effect of lidocaine (10 microM) were reproduced in hypokalaemic (3.0 mM K(+))…”
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Arrhythmogenic substrate and its modification by nicorandil in a murine model of long QT type 3 syndrome by Hothi, Sandeep S., Booth, Stephen W., Sabir, Ian N., Killeen, Matthew J., Simpson, Fergus, Zhang, Yanmin, Grace, Andrew A., Huang, Christopher L.-H.

“…The gain-of-function Scn5a+/ΔKPQ mutation in the cardiac Na+ channel causes human long QT type 3 syndrome (LQT3) associated with ventricular arrhythmogenesis…”
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Risk stratification for sudden cardiac death by Sabir, Ian N., Usher-Smith, Juliet A., Huang, Christopher L.-H., Grace, Andrew A.

“…Recent advances in pharmacological and device-based therapies have provided a range of management options for patients at risk of sudden cardiac death (SCD)…”
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MO214EVALUATION OF THE EFFECT OF A POTASSIUM BINDER ON ARRHYTHMIA-RELATED CARDIOVASCULAR OUTCOMES IN PATIENTS ON CHRONIC HAEMODIALYSIS WITH RECURRENT HYPERKALAEMIA: DESIGN AND RATIONALE FOR THE SODIUM ZIRCONIUM CYCLOSILICATE DIALIZE-OUTCOMES STUDY by Fishbane, Steven, Jadoul, Michel, Dember, Laura M, Kovesdy, Csaba, Sabir, Ian, Al-Shurbaji, Ayman, Thoren, Fredrik, Katona, Brian G, Guzman, Nicolas, Xu, John, Herzog, Charles A

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Persistent growth-promoting effects of vosoritide in children with achondroplasia are accompanied by improvements in physical and social aspects of health-related quality of life by Savarirayan, Ravi, Irving, Melita, Wilcox, William R., Bacino, Carlos A., Hoover-Fong, Julie E., Harmatz, Paul, Polgreen, Lynda E., Mohnike, Klaus, Prada, Carlos E., Kubota, Takuo, Arundel, Paul, Leiva-Gea, Antonio, Rowell, Richard, Low, Andrea, Sabir, Ian, Huntsman-Labed, Alice, Day, Jonathan

“…: Evaluate the impact of vosoritide on health-related quality of life in children with achondroplasia. Participants received vosoritide (15 μg/kg/day) in an…”
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