Revisiting the Daily Timing of POS Phagocytosis

Retinal pigment epithelium (RPE) cells daily ingest the tips of the photoreceptor outer segments (POSs), with phagosome number varying throughout a 24-h cycle. A major focus in the literature has been on a peak in phagosome concentration shortly after lights-on. Moreover, this peak has frequently be...

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Bibliographic Details
Published in:	Advances in experimental medicine and biology Vol. 1415; p. 515
Main Authors:	Paniagua, Antonio E, Sabharwal, Harjas S, Kethu, Kausalya, Chang, Andrew W, Williams, David S
Format:	Journal Article
Language:	English
Published:	United States 2023
Subjects:	Cells, Cultured Neurons Phagocytosis Phagosomes - metabolism Retinal Photoreceptor Cell Outer Segment Retinal Pigment Epithelium Daily rhythm Phagosome RPE Phagocytosis Photoreceptor outer segment
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Summary:	Retinal pigment epithelium (RPE) cells daily ingest the tips of the photoreceptor outer segments (POSs), with phagosome number varying throughout a 24-h cycle. A major focus in the literature has been on a peak in phagosome concentration shortly after lights-on. Moreover, this peak has frequently been inferred to represent a peak in POS tip ingestion. Here, we have reviewed old and new literature on the daily cycle of phagosome number in the RPE and conclude that there is more variation in the timing of phagosome concentration peaks than is currently acknowledged. We also discuss that phagosome quantity is affected by the rate of phagosome degradation as well as the rate of ingestion; given that phagosome half-life may not be constant throughout the daily cycle, maximal POS ingestion may not necessarily coincide with a peak in phagosome concentration.
ISSN:	0065-2598
DOI:	10.1007/978-3-031-27681-1_75