Search Results - "Sabbah, Dima A."

Review on Epidermal Growth Factor Receptor (EGFR) Structure, Signaling Pathways, Interactions, and Recent Updates of EGFR Inhibitors by Sabbah, Dima A, Hajjo, Rima, Sweidan, Kamal

“…The epidermal growth factor receptor (EGFR) belongs to the ERBB family of tyrosine kinase receptors. EGFR signaling cascade is a key regulator in cell…”
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Shedding the Light on Post-Vaccine Myocarditis and Pericarditis in COVID-19 and Non-COVID-19 Vaccine Recipients by Hajjo, Rima, Sabbah, Dima A., Bardaweel, Sanaa K., Tropsha, Alexander

“…Myocarditis and pericarditis have been linked recently to COVID-19 vaccines without exploring the underlying mechanisms, or compared to cardiac adverse events…”
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Monoamine Oxidase (MAO) as a Potential Target for Anticancer Drug Design and Development by Aljanabi, Reem, Alsous, Lina, Sabbah, Dima A, Gul, Halise Inci, Gul, Mustafa, Bardaweel, Sanaa K

“…Monoamine oxidases (MAOs) are oxidative enzymes that catalyze the conversion of biogenic amines into their corresponding aldehydes and ketones through…”
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Sitagliptin: a potential drug for the treatment of COVID-19? by Bardaweel, Sanaa K., Hajjo, Rima, Sabbah, Dima A.

“…Recently, an outbreak of a fatal coronavirus, SARS-CoV-2, has emerged from China and is rapidly spreading worldwide. Possible interaction of SARS-CoV-2 with…”
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An Updated Review on SARS-CoV-2 Main Proteinase (M Pro ): Protein Structure and Small-Molecule Inhibitors by Sabbah, Dima A, Hajjo, Rima, Bardaweel, Sanaa K, Zhong, Haizhen A

“…[Coronaviruses (CoVs) are enveloped positive-stranded RNA viruses with spike (S) protein projections that allow the virus to enter and infect host cells. The S…”
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Advances in the Development of Class I Phosphoinositide 3-Kinase (PI3K) Inhibitors by Sabbah, Dima A, Hu, Jian, Zhong, Haizhen A

“…The PI3K signaling cascade is the key moderator of cell proliferation, survival, motility, and apoptosis. Class I PI3K proteins are well characterized and…”
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Targeting Human Proteins for Antiviral Drug Discovery and Repurposing Efforts: A Focus on Protein Kinases by Hajjo, Rima, Sabbah, Dima A, Abusara, Osama H, Kharmah, Reham, Bardaweel, Sanaa

“…Despite the great technological and medical advances in fighting viral diseases, new therapies for most of them are still lacking, and existing antivirals…”
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N -Phenyl-6-Chloro-4-Hydroxy-2-Quinolone-3-CarboxAmides: Molecular Docking, Synthesis, and Biological Investigation as Anticancer Agents by Sabbah, Dima A, Haroon, Rawan A, Bardaweel, Sanaa K, Hajjo, Rima, Sweidan, Kamal

“…Cancer is a multifactorial disease and the second leading cause of death worldwide. Diverse factors induce carcinogenesis, such as diet, smoking, radiation,…”
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Unlocking the Potential of the Human Microbiome for Identifying Disease Diagnostic Biomarkers by Hajjo, Rima, Sabbah, Dima A, Al Bawab, Abdel Qader

“…The human microbiome encodes more than three million genes, outnumbering human genes by more than 100 times, while microbial cells in the human microbiota…”
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Analyzing the Systems Biology Effects of COVID-19 mRNA Vaccines to Assess Their Safety and Putative Side Effects by Hajjo, Rima, Sabbah, Dima A, Tropsha, Alexander

“…COVID-19 vaccines have been instrumental tools in reducing the impact of SARS-CoV-2 infections around the world by preventing 80% to 90% of hospitalizations…”
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Gold Nanocomplex Strongly Modulates the PI3K/Akt Pathway and Other Pathways in MCF-7 Breast Cancer Cell Line by Mahmoud, Nouf N, Abuarqoub, Duaa, Zaza, Rand, Sabbah, Dima A, Khalil, Enam A, Abu-Dahab, Rana

“…Conjugating drugs with gold nanoparticles (GNP) is a key strategy in cancer therapy. Herein, the potential inhibition of the phosphatidylinositol 3-kinase…”
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A Review of the Recent Advances in Alzheimer's Disease Research and the Utilization of Network Biology Approaches for Prioritizing Diagnostics and Therapeutics by Hajjo, Rima, Sabbah, Dima A, Abusara, Osama H, Al Bawab, Abdel Qader

“…Alzheimer's disease (AD) is a polygenic multifactorial neurodegenerative disease that, after decades of research and development, is still without a cure…”
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Identifying a causal link between prolactin signaling pathways and COVID-19 vaccine-induced menstrual changes by Hajjo, Rima, Momani, Ensaf, Sabbah, Dima A., Baker, Nancy, Tropsha, Alexander

“…COVID-19 vaccines have been instrumental tools in the fight against SARS-CoV-2 helping to reduce disease severity and mortality. At the same time, just like…”
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The In Vitro Immunomodulatory Effects of Gold Nanocomplex on THP-1-Derived Macrophages by Abuarqoub, Duaa, Mahmoud, Nouf N., Zaza, Rand, Abu-Dahab, Rana, Khalil, Enam A., Sabbah, Dima A.

“…Introduction. This study is aimed at investigating the immunological response after treating THP-1 cells with gold nanorods conjugated with a…”
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Docking Studies on Isoform-Specific Inhibition of Phosphoinositide-3-Kinases by Sabbah, Dima A, Vennerstrom, Jonathan L, Zhong, Haizhen

“…Phosphatidylinositol 3-kinase α (PI3Kα) is a promising target for anticancer drug design. Oncogenic mutation H1047R in the catalytic domain is observed in many…”
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Molecular Modeling, Synthesis and Biological Evaluation of N -Phenyl-4-Hydroxy-6-Methyl-2-Quinolone-3-CarboxAmides as Anticancer Agents by Sabbah, Dima A, Hasan, Shaima' E, Abu Khalaf, Reema, Bardaweel, Sanaa K, Hajjo, Rima, Alqaisi, Khalid M, Sweidan, Kamal A, Al-Zuheiri, Aya M

“…The emergence of phosphatidylinositol 3-kinase (PI3Kα) in cancer development has accentuated its significance as a potential target for anticancer drug design…”
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Identification of Tumor-Specific MRI Biomarkers Using Machine Learning (ML) by Hajjo, Rima, Sabbah, Dima A, Bardaweel, Sanaa K, Tropsha, Alexander

“…The identification of reliable and non-invasive oncology biomarkers remains a main priority in healthcare. There are only a few biomarkers that have been…”
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Chemocentric Informatics Analysis: Dexamethasone Versus Combination Therapy for COVID-19 by Hajjo, Rima, Sabbah, Dima A, Bardaweel, Sanaa K

“…COVID-19 is a biphasic infectious disease with no approved vaccine or pharmacotherapy. The first drug that has shown promise in reducing COVID-19 mortality in…”
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Synthesis and in Vivo Lipid-Lowering Activity of Novel Imidazoles-5-carboxamide Derivatives in Triton-WR-1339-Induced Hyperlipidemic Wistar Rats by Jasim, Suhair H., Sheikha, Ghassan M. Abu, Abuzaid, Haneen M., Al-Qirim, Tariq M., Shattat, Ghassan F., Sabbah, Dima A., Ala, Samah A., Aboumair, Mustafa S., Sweidan, Kamal A., Bkhaitan, Majdi M.

“…A new series of imidazole-5-carboxamide derivatives were prepared and tested for their anti-hyperlipidemic activity in Triton-WR-1339-induced hyperlipidemic…”
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A cross-sectional study confirms temporary post-COVID-19 vaccine menstrual irregularity and the associated physiological changes among vaccinated women in Jordan by Almomani, Ensaf Y, Hajjo, Rima, Qablan, Ahmad, Sabbah, Dima A, Al-Momany, Abass

“…COVID-19 vaccines continue to save people's lives around the world; however, some vaccine adverse events have been a major concern which slowed down…”
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