Search Results - "Sabatini, L."

Dopaminergic Modulation of Synaptic Transmission in Cortex and Striatum by Tritsch, Nicolas X., Sabatini, Bernardo L.

“…Among the many neuromodulators used by the mammalian brain to regulate circuit function and plasticity, dopamine (DA) stands out as one of the most…”
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Anatomically segregated basal ganglia pathways allow parallel behavioral modulation by Lee, Jaeeon, Wang, Wengang, Sabatini, Bernardo L.

“…In the basal ganglia (BG), anatomically segregated and topographically organized feedforward circuits are thought to modulate multiple behaviors in parallel…”
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Striatal indirect pathway mediates exploration via collicular competition by Lee, Jaeeon, Sabatini, Bernardo L.

“…The ability to suppress actions that lead to a negative outcome and explore alternative actions is necessary for optimal decision making. Although the basal…”
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Mechanisms and functions of GABA co-release by Tritsch, Nicolas X., Granger, Adam J., Sabatini, Bernardo L.

“…The long-held doctrine that an individual neuron releases only one type of small molecule neurotransmitter has been challenged in recent years. In this…”
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Multipoint-Emitting Optical Fibers for Spatially Addressable In Vivo Optogenetics by Pisanello, Ferruccio, Sileo, Leonardo, Oldenburg, Ian A., Pisanello, Marco, Martiradonna, Luigi, Assad, John A., Sabatini, Bernardo L., De Vittorio, Massimo

“…Optical stimulation and silencing of neural activity is a powerful technique for elucidating the structure and function of neural circuitry. In most in vivo…”
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Excitatory/Inhibitory Synaptic Imbalance Leads to Hippocampal Hyperexcitability in Mouse Models of Tuberous Sclerosis by Bateup, Helen S., Johnson, Caroline A., Denefrio, Cassandra L., Saulnier, Jessica L., Kornacker, Karl, Sabatini, Bernardo L.

“…Neural circuits are regulated by activity-dependent feedback systems that tightly control network excitability and which are thought to be crucial for proper…”
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Caveolae in CNS arterioles mediate neurovascular coupling by Chow, Brian W., Nuñez, Vicente, Kaplan, Luke, Granger, Adam J., Bistrong, Karina, Zucker, Hannah L., Kumar, Payal, Sabatini, Bernardo L., Gu, Chenghua

“…Proper brain function depends on neurovascular coupling: neural activity rapidly increases local blood flow to meet moment-to-moment changes in regional brain…”
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Early hyperactivity and precocious maturation of corticostriatal circuits in Shank3B−/− mice by Peixoto, Rui T, Wang, Wengang, Croney, Donyell M, Kozorovitskiy, Yevgenia, Sabatini, Bernardo L

“…Peixoto et al . show that Shank3B −/− mice exhibit premature development and subsequent arrest of striatal afferent connectivity. This phenotype is a result of…”
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Antagonistic but Not Symmetric Regulation of Primary Motor Cortex by Basal Ganglia Direct and Indirect Pathways by Oldenburg, Ian A., Sabatini, Bernardo L.

“…Motor cortex, basal ganglia (BG), and thalamus are arranged in a recurrent loop whose activity guides motor actions. In the dominant model of the function of…”
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The Striatum Organizes 3D Behavior via Moment-to-Moment Action Selection by Markowitz, Jeffrey E., Gillis, Winthrop F., Beron, Celia C., Neufeld, Shay Q., Robertson, Keiramarie, Bhagat, Neha D., Peterson, Ralph E., Peterson, Emalee, Hyun, Minsuk, Linderman, Scott W., Sabatini, Bernardo L., Datta, Sandeep Robert

“…Many naturalistic behaviors are built from modular components that are expressed sequentially. Although striatal circuits have been implicated in action…”
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Competitive regulation of synaptic Ca2+ influx by D2 dopamine and A2A adenosine receptors by Higley, Michael J, Sabatini, Bernardo L

“…The authors combine optogenetics, two-photon microscopy and glutamate uncaging to study D2-type dopamine receptor modulation of glutamatergic transmission in…”
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Fasting Activation of AgRP Neurons Requires NMDA Receptors and Involves Spinogenesis and Increased Excitatory Tone by Liu, Tiemin, Kong, Dong, Shah, Bhavik P., Ye, Chianping, Koda, Shuichi, Saunders, Arpiar, Ding, Jun B., Yang, Zongfang, Sabatini, Bernardo L., Lowell, Bradford B.

“…AgRP neuron activity drives feeding and weight gain whereas that of nearby POMC neurons does the opposite. However, the role of excitatory glutamatergic input…”
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Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1 by Wang, Shuyu, Tsun, Zhi-Yang, Wolfson, Rachel L., Shen, Kuang, Wyant, Gregory A., Plovanich, Molly E., Yuan, Elizabeth D., Jones, Tony D., Chantranupong, Lynne, Comb, William, Wang, Tim, Bar-Peled, Liron, Zoncu, Roberto, Straub, Christoph, Kim, Choah, Park, Jiwon, Sabatini, Bernardo L., Sabatini, David M.

“…The mechanistic target of rapamycin complex 1 (mTORC1) protein kinase is a master growth regulator that responds to multiple environmental cues. Amino acids…”
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Anatomical and physiological plasticity of dendritic spines by ALVAREZ, Veronica A, SABATINI, Bernardo L

“…In excitatory neurons, most glutamatergic synapses are made on the heads of dendritic spines, each of which houses the postsynaptic terminal of a single…”
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Efficient and accurate extraction of in vivo calcium signals from microendoscopic video data by Zhou, Pengcheng, Resendez, Shanna L, Rodriguez-Romaguera, Jose, Jimenez, Jessica C, Neufeld, Shay Q, Giovannucci, Andrea, Friedrich, Johannes, Pnevmatikakis, Eftychios A, Stuber, Garret D, Hen, Rene, Kheirbek, Mazen A, Sabatini, Bernardo L, Kass, Robert E, Paninski, Liam

“…In vivo calcium imaging through microendoscopic lenses enables imaging of previously inaccessible neuronal populations deep within the brains of freely moving…”
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Synapses and Alzheimer's disease by Sheng, Morgan, Sabatini, Bernardo L, Südhof, Thomas C

“…Alzheimer's disease (AD) is a major cause of dementia in the elderly. Pathologically, AD is characterized by the accumulation of insoluble aggregates of…”
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Recombinant Probes for Visualizing Endogenous Synaptic Proteins in Living Neurons by Gross, Garrett G., Junge, Jason A., Mora, Rudy J., Kwon, Hyung-Bae, Olson, C. Anders, Takahashi, Terry T., Liman, Emily R., Ellis-Davies, Graham C.R., McGee, Aaron W., Sabatini, Bernardo L., Roberts, Richard W., Arnold, Don B.

“…The ability to visualize endogenous proteins in living neurons provides a powerful means to interrogate neuronal structure and function. Here we…”
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Corelease of acetylcholine and GABA from cholinergic forebrain neurons by Saunders, Arpiar, Granger, Adam J, Sabatini, Bernardo L

“…Neurotransmitter corelease is emerging as a common theme of central neuromodulatory systems. Though corelease of glutamate or GABA with acetylcholine has been…”
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Genetically Distinct Parallel Pathways in the Entopeduncular Nucleus for Limbic and Sensorimotor Output of the Basal Ganglia by Wallace, Michael L., Saunders, Arpiar, Huang, Kee Wui, Philson, Adrienne C., Goldman, Melissa, Macosko, Evan Z., McCarroll, Steven A., Sabatini, Bernardo L.

“…The basal ganglia (BG) integrate inputs from diverse sensorimotor, limbic, and associative regions to guide action-selection and goal-directed behaviors. The…”
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Molecular and anatomical organization of the dorsal raphe nucleus by Huang, Kee Wui, Ochandarena, Nicole E, Philson, Adrienne C, Hyun, Minsuk, Birnbaum, Jaclyn E, Cicconet, Marcelo, Sabatini, Bernardo L

“…The dorsal raphe nucleus (DRN) is an important source of neuromodulators and has been implicated in a wide variety of behavioral and neurological disorders…”
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