Endometrial Injury May Increase the Pregnancy Rate in Patients Undergoing Intrauterine Insemination: An Interventional Randomized Clinical Trial

Endometrial Injury May Increase the Pregnancy Rate in Patients Undergoing Intrauterine Insemination: An Interventional Randomized Clinical Trial

This study aimed to investigate the effect of endometrial injury using Pipelle catheter in the follicular phase (cycle day 5, 6, or 7) of the stimulation cycle on pregnancy rates in patients undergoing intrauterine insemination. This prospective randomized controlled study was carried out in the Ass...

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Bibliographic Details
Published in:Reproductive sciences (Thousand Oaks, Calif.) Vol. 23; no. 10; p. 1326
Main Authors: Bahaa Eldin, Ahmed M, Abdelmaabud, Karim H, Laban, Mohamed, Hassanin, Alaa S, Tharwat, Ahmed A, Aly, Tarek R, Elbohoty, Ahmed E, Elsayed, Helmy M, Ibrahim, Ahmed M, Ibrahim, Mohammed E, Sabaa, Haitham M, Abdelrazik, Azza A, Abdelhady, Ibrahim
Format: Journal Article
Language:English
Published: United States 01-10-2016
Subjects:
Adult
Catheters
Endometrium - injuries
Female
Follicular Phase
Humans
Insemination, Artificial - methods
Pregnancy
Pregnancy Rate
Prospective Studies
Young Adult
endometrial scratch
infertility
intrauterine insemination
endometrial injury
Pipelle
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Summary:This study aimed to investigate the effect of endometrial injury using Pipelle catheter in the follicular phase (cycle day 5, 6, or 7) of the stimulation cycle on pregnancy rates in patients undergoing intrauterine insemination. This prospective randomized controlled study was carried out in the Assisted Reproductive Technology Unit of Ain Shams University Maternity Hospital, Cairo, Egypt, from July 1, 2013 to August 31, 2015. Three hundred sixty women, 20 to 35 years of age, with patent fallopian tubes, mild male factor infertility, or unexplained infertility were recruited. Participants were allocated randomly into 2 groups: experimental arm and control arm. Women in the experimental arm underwent endometrial biopsy using a Pipelle catheter on day 5, 6, or 7 of the stimulation cycle combined with intrauterine insemination. Women in the control group underwent intrauterine insemination with no endometrial biopsy done. The primary outcomes were the clinical and chemical pregnancy rates. Data of 344 participants were statistically analyzed. The chemical pregnancy rate was 23.66% in the experimental arm and 10.85% in the control arm (P = .002). The clinical pregnancy rate was 18.93% in the experimental arm and 7.42% in the control arm (P = .003). Endometrial injury using a Pipelle catheter in the stimulation cycle may improve pregnancy rates in women undergoing intrauterine insemination.
ISSN:1933-7205
DOI:10.1177/1933719116638191