Search Results - "Saba, Laura M."

The regulatory landscape of multiple brain regions in outbred heterogeneous stock rats by Munro, Daniel, Wang, Tengfei, Chitre, Apurva S, Polesskaya, Oksana, Ehsan, Nava, Gao, Jianjun, Gusev, Alexander, Woods, Leah C Solberg, Saba, Laura M, Chen, Hao, Palmer, Abraham A, Mohammadi, Pejman

“…Heterogeneous Stock (HS) rats are a genetically diverse outbred rat population that is widely used for studying genetics of behavioral and physiological…”
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Aptardi predicts polyadenylation sites in sample-specific transcriptomes using high-throughput RNA sequencing and DNA sequence by Lusk, Ryan, Stene, Evan, Banaei-Kashani, Farnoush, Tabakoff, Boris, Kechris, Katerina, Saba, Laura M.

“…Annotation of polyadenylation sites from short-read RNA sequencing alone is a challenging computational task. Other algorithms rooted in DNA sequence predict…”
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RCFGL: Rapid Condition adaptive Fused Graphical Lasso and application to modeling brain region co-expression networks by Seal, Souvik, Li, Qunhua, Basner, Elle Butler, Saba, Laura M, Kechris, Katerina

“…Inferring gene co-expression networks is a useful process for understanding gene regulation and pathway activity. The networks are usually undirected graphs…”
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Elevated Nrf-2 responses are insufficient to mitigate protein carbonylation in hepatospecific PTEN deletion mice by Petersen, Dennis R, Saba, Laura M, Sayin, Volkan I, Papagiannakopoulos, Thales, Schmidt, Edward E, Merrill, Gary F, Orlicky, David J, Shearn, Colin T

“…In the liver, a contributing factor in the pathogenesis of non-alcoholic fatty liver disease (NASH) is oxidative stress, which leads to the accumulation of…”
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Evaluation and characterization of expression quantitative trait analysis methods in the Hybrid Rat Diversity Panel by Pattee, Jack, Vanderlinden, Lauren A, Mahaffey, Spencer, Hoffman, Paula, Tabakoff, Boris, Saba, Laura M

“…The Hybrid Rat Diversity Panel (HRDP) is a stable and well-characterized set of more than 90 inbred rat strains that can be leveraged for systems genetics…”
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Development of a tissue augmented Bayesian model for expression quantitative trait loci analysis by Zhuang, Yong Hua, Wade, Kristen, Saba, Laura M, Kechris, Katerina

“…Expression quantitative trait loci (eQTL) analyses detect genetic variants (SNPs) associated with RNA expression levels of genes. The conventional eQTL…”
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Systems genetics analysis of the LXS recombinant inbred mouse strains:Genetic and molecular insights into acute ethanol tolerance by Radcliffe, Richard A, Dowell, Robin, Odell, Aaron T, Richmond, Phillip A, Bennett, Beth, Larson, Colin, Kechris, Katerina, Saba, Laura M, Rudra, Pratyaydipta, Wen, Shi

“…We have been using the Inbred Long- and Short-Sleep mouse strains (ILS, ISS) and a recombinant inbred panel derived from them, the LXS, to investigate the…”
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Alcohol Sensitivity as an Endophenotype of Alcohol Use Disorder: Exploring Its Translational Utility between Rodents and Humans by Parker, Clarissa C, Lusk, Ryan, Saba, Laura M

“…Alcohol use disorder (AUD) is a complex, chronic, relapsing disorder with multiple interacting genetic and environmental influences. Numerous studies have…”
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Beyond Genes: Inclusion of Alternative Splicing and Alternative Polyadenylation to Assess the Genetic Architecture of Predisposition to Voluntary Alcohol Consumption in Brain of the HXB/BXH Recombinant Inbred Rat Panel by Lusk, Ryan, Hoffman, Paula L, Mahaffey, Spencer, Rosean, Samuel, Smith, Harry, Silhavy, Jan, Pravenec, Michal, Tabakoff, Boris, Saba, Laura M

“…Post transcriptional modifications of RNA are powerful mechanisms by which eukaryotes expand their genetic diversity. For instance, researchers estimate that…”
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Investigating RNA expression profiles altered by nicotinamide mononucleotide therapy in a chronic model of alcoholic liver disease by Assiri, Mohammed A, Ali, Hadi R, Marentette, John O, Yun, Youngho, Liu, Juan, Hirschey, Matthew D, Saba, Laura M, Harris, Peter S, Fritz, Kristofer S

“…Chronic alcohol consumption is a significant cause of liver disease worldwide. Several biochemical mechanisms have been linked to the initiation and…”
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Knockout of the Gsta4 Gene in Male Mice Leads to an Altered Pattern of Hepatic Protein Carbonylation and Enhanced Inflammation Following Chronic Consumption of an Ethanol Diet by Shearn, Colin T., Pulliam, Casey F., Pedersen, Kim, Meredith, Kyle, Mercer, Kelly E., Saba, Laura M., Orlicky, David J., Ronis, Martin J., Petersen, Dennis R.

“…Background Glutathione S‐transferase A4‐4 (GSTA4) is a key enzyme for removal of toxic lipid peroxidation products such as 4‐hydroxynonenal (4‐HNE). In this…”
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Association Between Variants in Calcineurin Inhibitor Pharmacokinetic and Pharmacodynamic Genes and Renal Dysfunction in Adult Heart Transplant Recipients by Oreschak, Kris, Saba, Laura M, Rafaels, Nicholas, Ambardekar, Amrut V, Deininger, Kimberly M, Page, 2nd, Robert L, Lindenfeld, JoAnn, Aquilante, Christina L

“…: The goal of the study was to assess the relationship between single nucleotide variants (SNVs) in calcineurin inhibitor (CNI) pharmacokinetic and…”
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Whole brain and brain regional coexpression network interactions associated with predisposition to alcohol consumption by Vanderlinden, Lauren A, Saba, Laura M, Kechris, Katerina, Miles, Michael F, Hoffman, Paula L, Tabakoff, Boris

“…To identify brain transcriptional networks that may predispose an animal to consume alcohol, we used weighted gene coexpression network analysis (WGCNA)…”
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Identification of Genes Involved in the Differentiation of R7y and R7p Photoreceptor Cells in Drosophila by Earl, James B, Vanderlinden, Lauren A, Jacobsen, Thomas L, Aldrich, John C, Saba, Laura M, Britt, Steven G

“…Abstract The R7 and R8 photoreceptor cells of the Drosophila compound eye mediate color vision. Throughout the majority of the eye, these cells occur in two…”
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Liver-Specific Deletion of Phosphatase and Tensin Homolog Deleted on Chromosome 10 Significantly Ameliorates Chronic EtOH-Induced Increases in Hepatocellular Damage by Shearn, Colin T, Orlicky, David J, McCullough, Rebecca L, Jiang, Hua, Maclean, Kenneth N, Mercer, Kelly E, Stiles, Bangyan L, Saba, Laura M, Ronis, Martin J, Petersen, Dennis R

“…Alcoholic liver disease is a significant contributor to global liver failure. In murine models, chronic ethanol consumption dysregulates PTEN/Akt signaling…”
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Deletion of GSTA4-4 results in increased mitochondrial post-translational modification of proteins by reactive aldehydes following chronic ethanol consumption in mice by Shearn, Colin T, Fritz, Kristofer S, Shearn, Alisabeth H, Saba, Laura M, Mercer, Kelly E, Engi, Bridgette, Galligan, James J, Zimniak, Piotr, Orlicky, David J, Ronis, Martin J, Petersen, Dennis R

“…Chronic alcohol consumption induces hepatic oxidative stress resulting in production of highly reactive electrophilic α/β-unsaturated aldehydes that have the…”
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Zolpidem prescribing practices before and after Food and Drug Administration required product labeling changes by Norman, Jessica L, Fixen, Danielle R, Saseen, Joseph J, Saba, Laura M, Linnebur, Sunny A

“…Background: Women have higher morning serum zolpidem concentrations than men after taking an evening dose, potentially leading to increased risk of harm. On 19…”
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Comparative Proteomic Analysis of Carbonylated Proteins from the Striatum and Cortex of Pesticide-Treated Mice by Roede, James R., Caudle, W. Michael, Saba, Laura M., Richardson, Jason R., Lohr, Kelly M., Walker, Douglas I., Coughlan, Christina, Fritz, Kristofer S.

“…Epidemiological studies indicate exposures to the herbicide paraquat (PQ) and fungicide maneb (MB) are associated with increased risk of Parkinson’s disease…”
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Peptide−Spectrum Match Validation with Internal Standards (P−VIS): Internally-Controlled Validation of Mass Spectrometry-Based Peptide Identifications by Wiles, Timothy Aaron, Saba, Laura M, Delong, Thomas

“…Liquid chromatography–tandem mass spectrometry is an increasingly powerful tool for studying proteins in the context of disease. As technological advances in…”
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Complement opsonization of nanoparticles: Differences between humans and preclinical species by Li, Yue, Wang, Guankui, Griffin, Lynn, Banda, Nirmal K., Saba, Laura M., Groman, Ernest V., Scheinman, Robert, Moghimi, S. Moein, Simberg, Dmitri

“…The complement system plays a key role in opsonization and immune clearance of engineered nanoparticles. Understanding the efficiency, inter-subject, and…”
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