Search Results - "Saavedra, Jannette"
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Growth hormone receptor deficiency is associated with a major reduction in pro-aging signaling, cancer, and diabetes in humans
Published in Science translational medicine (16-02-2011)“…Mutations in growth signaling pathways extend life span, as well as protect against age-dependent DNA damage in yeast and decrease insulin resistance and…”
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Cancer in growth hormone excess and growth hormone deficit
Published in Endocrine-related cancer (01-10-2023)“…The relationship between growth hormone (GH) excess and cancer is a controversial matter. Until 2016, most studies in patients with acromegaly found links with…”
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Cancer in Ecuadorian subjects with Laron syndrome (ELS)
Published in Endocrine-related cancer (01-06-2023)“…Meta-analyses from 2018–2022 have shown that obesity increases the risk of various cancers such as acute myeloid lymphoma, chronic myeloid lymphoma, diffuse…”
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GH Receptor Deficiency in Ecuadorian Adults Is Associated With Obesity and Enhanced Insulin Sensitivity
Published in The journal of clinical endocrinology and metabolism (01-07-2015)“…Context: Ecuadorian subjects with GH receptor deficiency (GHRD) have not developed diabetes, despite obesity. Objective: We sought to determine the metabolic…”
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Recommended IGF-I Dosage Causes Greater Fat Accumulation and Osseous Maturation Than Lower Dosage and May Compromise Long-term Growth Effects
Published in The journal of clinical endocrinology and metabolism (01-02-2013)“…Context: The maximum dose of IGF-I recommended for treatment of GH insensitivity is commonly used. Objective: The aim was to test the hypothesis that a lower…”
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Assessing insulin sensitivity and resistance in syndromes of severe short stature
Published in Growth hormone & IGF research (01-08-2020)“…Individuals affected with two genetic syndromes identified in Ecuador have severe short stature and diminished insulin secretion, along with essentially…”
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Is ultrasonography useful in predicting thyroid cancer in children with thyroid nodules and apparently benign cytopathologic features?
Published in Hormone research in paediatrics (01-01-2011)“…To assess whether the presence of certain findings on thyroid ultrasonography (US) correctly diagnoses malignancy even when a fine-needle aspiration biopsy…”
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