Search Results - "Saatman, Kathryn"

Regional Neurodegeneration and Gliosis Are Amplified by Mild Traumatic Brain Injury Repeated at 24-Hour Intervals by Bolton, Amanda N, Saatman, Kathryn E

“…ABSTRACTMost traumatic brain injuries (TBIs) that occur every year are classified as “mild.” Individuals involved in high-risk activities may sustain multiple…”
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Central Infusion of Insulin-Like Growth Factor-1 Increases Hippocampal Neurogenesis and Improves Neurobehavioral Function after Traumatic Brain Injury by Carlson, Shaun W, Saatman, Kathryn E

“…Traumatic brain injury (TBI) produces neuronal dysfunction and cellular loss that can culminate in lasting impairments in cognitive and motor abilities…”
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Astrocyte-Specific Overexpression of Insulin-Like Growth Factor-1 Protects Hippocampal Neurons and Reduces Behavioral Deficits following Traumatic Brain Injury in Mice by Madathil, Sindhu K, Carlson, Shaun W, Brelsfoard, Jennifer M, Ye, Ping, D'Ercole, A Joseph, Saatman, Kathryn E

“…Traumatic brain injury (TBI) survivors often suffer from long-lasting cognitive impairment that stems from hippocampal injury. Systemic administration of…”
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Repeated Closed Head Injury in Mice Results in Sustained Motor and Memory Deficits and Chronic Cellular Changes by Bolton Hall, Amanda N, Joseph, Binoy, Brelsfoard, Jennifer M, Saatman, Kathryn E

“…Millions of mild traumatic brain injuries (TBIs) occur every year in the United States, with many people subject to multiple head injuries that can lead to…”
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Calpains mediate axonal cytoskeleton disintegration during Wallerian degeneration by Ma, Marek, Ferguson, Toby A, Schoch, Kathleen M, Li, Jian, Qian, Yaping, Shofer, Frances S, Saatman, Kathryn E, Neumar, Robert W

“…Abstract In both the central nervous system (CNS) and peripheral nervous system (PNS), transected axons undergo Wallerian degeneration. Even though Augustus…”
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IGF-1 mediated Neurogenesis Involves a Novel RIT1/Akt/Sox2 Cascade by Mir, Sajad, Cai, Weikang, Carlson, Shaun W., Saatman, Kathryn E., Andres, Douglas A.

“…Insulin-like growth factor 1 (IGF-1) is known to have diverse effects on brain structure and function, including the promotion of stem cell proliferation and…”
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Experimental Designs for Repeated Mild Traumatic Brain Injury: Challenges and Considerations by Bolton-Hall, Amanda N, Hubbard, W Brad, Saatman, Kathryn E

“…Mild traumatic brain injury (mild TBI) is a growing public concern, as evidence mounts that even brain injuries classified as "mild" can result in persistent…”
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Acute gastrointestinal permeability after traumatic brain injury in mice precedes a bloom in Akkermansia muciniphila supported by intestinal hypoxia by DeSana, Anthony J., Estus, Steven, Barrett, Terrence A., Saatman, Kathryn E.

“…Traumatic brain injury (TBI) increases gastrointestinal morbidity and associated mortality. Clinical and preclinical studies implicate gut dysbiosis as a…”
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Calpain as a Therapeutic Target in Traumatic Brain Injury by Saatman, Kathryn E., Creed, Jennifer, Raghupathi, Ramesh

“…The family of calcium-activated neutral proteases, calpains, appears to play a key role in neuropathologic events following traumatic brain injury (TBI)…”
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Therapeutic potential of natural compounds from Chinese medicine in acute and subacute phases of ischemic stroke by Zhang, Bei, Saatman, Kathryn, Chen, Lei

“…Stroke is one of the leading causes of death and disability in adults worldwide, resulting in huge social and financial burdens. Extracts from herbs,…”
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Doxorubicin-induced elevated oxidative stress and neurochemical alterations in brain and cognitive decline: protection by MESNA and insights into mechanisms of chemotherapy-induced cognitive impairment ("chemobrain") by Keeney, Jeriel T R, Ren, Xiaojia, Warrier, Govind, Noel, Teresa, Powell, David K, Brelsfoard, Jennifer M, Sultana, Rukhsana, Saatman, Kathryn E, Clair, Daret K St, Butterfield, D Allan

“…Chemotherapy-induced cognitive impairment (CICI) is now widely recognized as a real and too common complication of cancer chemotherapy experienced by an…”
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Brain microvascular injury and white matter disease provoked by diabetes‐associated hyperamylinemia by Ly, Han, Verma, Nirmal, Wu, Fengen, Liu, Miao, Saatman, Kathryn E., Nelson, Peter T., Slevin, John T., Goldstein, Larry B., Biessels, Geert Jan, Despa, Florin

“…Objective The brain blood vessels of patients with type 2 diabetes and dementia have deposition of amylin, an amyloidogenic hormone cosecreted with insulin. It…”
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Classification of traumatic brain injury for targeted therapies by Saatman, Kathryn E, Duhaime, Ann-Christine, Bullock, Ross, Maas, Andrew I R, Valadka, Alex, Manley, Geoffrey T

“…The heterogeneity of traumatic brain injury (TBI) is considered one of the most significant barriers to finding effective therapeutic interventions. In…”
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Insulin-like growth factor-1 overexpression increases long-term survival of posttrauma-born hippocampal neurons while inhibiting ectopic migration following traumatic brain injury by Littlejohn, Erica L, Scott, Danielle, Saatman, Kathryn E

“…Cellular damage associated with traumatic brain injury (TBI) manifests in motor and cognitive dysfunction following injury. Experimental models of TBI reveal…”
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A role for insulin-like growth factor-1 in hippocampal plasticity following traumatic brain injury by Williams, Hannah C, Carlson, Shaun W, Saatman, Kathryn E

“…Traumatic brain injury (TBI) initiates a constellation of secondary injury cascades, leading to neuronal damage and dysfunction that is often beyond the scope…”
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Fractionated mitochondrial magnetic separation for isolation of synaptic mitochondria from brain tissue by Hubbard, W. Brad, Harwood, Christopher L., Prajapati, Paresh, Springer, Joe E., Saatman, Kathryn E., Sullivan, Patrick G.

“…While mitochondria maintain essential cellular functions, such as energy production, calcium homeostasis, and regulating programmed cellular death, they also…”
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Conditional Overexpression of Insulin-Like Growth Factor-1 Enhances Hippocampal Neurogenesis and Restores Immature Neuron Dendritic Processes After Traumatic Brain Injury by Carlson, Shaun W, Madathil, Sindhu K, Sama, Diana M, Gao, Xiang, Chen, Jinhui, Saatman, Kathryn E

“…ABSTRACTTraumatic brain injury (TBI) is associated with neuronal damage or neuronal death in the hippocampus, a region critical for cognitive function…”
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EcoHIV-Infected Mice Show No Signs of Platelet Activation by Alfar, Hammodah R, Nthenge-Ngumbau, Dominic Ngima, Saatman, Kathryn E, Whiteheart, Sidney W

“…Platelets express several surface receptors that could interact with different viruses. To understand the mechanisms of HIV-1's interaction with platelets, we…”
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Speckle contrast diffuse correlation tomography of cerebral blood flow in perinatal disease model of neonatal piglets by Huang, Chong, Mazdeyasna, Siavash, Mohtasebi, Mehrana, Saatman, Kathryn E., Cheng, Qiang, Yu, Guoqiang, Chen, Lei

“…We adapted and tested an innovative noncontact speckle contrast diffuse correlation tomography (scDCT) system for 3D imaging of cerebral blood flow (CBF)…”
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Neuroinflammation and neurologic deficits in diabetes linked to brain accumulation of amylin by Srodulski, Sarah, Sharma, Savita, Bachstetter, Adam B, Brelsfoard, Jennifer M, Pascual, Conrado, Xie, Xinmin Simon, Saatman, Kathryn E, Van Eldik, Linda J, Despa, Florin

“…We recently found that brain tissue from patients with type-2 diabetes (T2D) and cognitive impairment contains deposits of amylin, an amyloidogenic hormone…”
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