Search Results - "Saari, Sina"
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Molecular pathways behind acquired obesity: Adipose tissue and skeletal muscle multiomics in monozygotic twin pairs discordant for BMI
Published in Cell reports. Medicine (20-04-2021)“…Tissue-specific mechanisms prompting obesity-related development complications in humans remain unclear. We apply multiomics analyses of subcutaneous adipose…”
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The most recently discovered carbonic anhydrase, CA XV, is expressed in the thick ascending limb of Henle and in the collecting ducts of mouse kidney
Published in PloS one (10-03-2010)“…Carbonic anhydrases (CAs) are key enzymes for physiological pH regulation, including the process of urine acidification. Previous studies have identified seven…”
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Differential Plasma N-Glycopeptides in Monozygotic Twin Pairs Discordant for BMI
Published in Obesity (Silver Spring, Md.) (01-11-2023)“…Background: N-glycosylation of proteins is a complex non-template post-translational modification, which influences protein function and is very sensitive to…”
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Effects of Diet on the Developmental Metabolism of Drosophila Expressing the Ciona intestinalis Alternative Oxidase
Published in The FASEB journal (01-05-2021)“…The expression of the mitochondrial alternative oxidase AOX from Ciona intestinalis (Tunicata: Ascidiacea) has provided clear beneficial effects in a variety…”
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Molecular phenotyping uncovers differences in basic housekeeping functions among closely related species of hares (Lepus spp., Lagomorpha: Leporidae)
Published in Molecular ecology (01-08-2023)“…Speciation is a fundamental evolutionary process, which results in genetic differentiation of populations and manifests as discrete morphological,…”
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Alternative respiratory chain enzymes: Therapeutic potential and possible pitfalls
Published in Biochimica et biophysica acta. Molecular basis of disease (01-04-2019)“…The alternative respiratory chain (aRC), comprising the alternative NADH dehydrogenases (NDX) and quinone oxidases (AOX), is found in microbes, fungi and…”
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Nicotinamide riboside improves muscle mitochondrial biogenesis, satellite cell differentiation, and gut microbiota in a twin study
Published in Science advances (13-01-2023)“…Nicotinamide adenine dinucleotide (NAD ) precursor nicotinamide riboside (NR) has emerged as a promising compound to improve obesity-associated mitochondrial…”
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Expression of Ciona intestinalis AOX causes male reproductive defects in Drosophila melanogaster
Published in BMC developmental biology (03-07-2017)“…Mitochondrial alternative respiratory-chain enzymes are phylogenetically widespread, and buffer stresses affecting oxidative phosphorylation in species that…”
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Alternative oxidase confers nutritional limitation on Drosophila development
Published in Journal of experimental zoology. Part A, Ecological and integrative physiology (01-07-2019)“…The mitochondrial alternative oxidase, AOX, present in most eukaryotes apart from vertebrates and insects, catalyzes the direct oxidation of ubiquinol by…”
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