Search Results - "Saar Gomes, Rodrigo"

Interleukin 32: a novel player in the control of infectious diseases by Ribeiro‐Dias, Fátima, Saar Gomes, Rodrigo, Lima Silva, Lucas Luiz, Santos, Jéssica Cristina, Joosten, Leo A. B.

“…Interleukin 32 (IL‐32) is a proinflammatory cytokine, expressed as 9 distinct isoforms. The most active isoform is the predominantly intracellular‐functioning…”
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Toll‐like receptor 10 controls TLR2‐induced cytokine production in monocytes from patients with Parkinson's disease by Rocha Sobrinho, Hermínio Maurício, Gomes, Rodrigo, Silva, Delson José, Quixabeira, Valéria Bernadete Leite, Joosten, Leo A. B., Cardoso, Cristina, Ribeiro‐Dias, Fátima

“…Peripheral inflammation, particularly mediated by monocytes, can cause neuroinflammation in Parkinson's disease (PD). We investigated the mechanism of…”
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The Antileishmanial Potential of C-3 Functionalized Isobenzofuranones against Leishmania (Leishmania) Infantum Chagasi by Pereira, Wagner Luiz, de Souza Vasconcellos, Raphael, Mariotini-Moura, Christiane, Saar Gomes, Rodrigo, Firmino, Rafaela de Cássia, da Silva, Adalberto Manoel, Silva Júnior, Abelardo, Bressan, Gustavo Costa, Almeida, Márcia Rogéria, Crocco Afonso, Luís Carlos, Teixeira, Róbson Ricardo, Lopes Rangel Fietto, Juliana

“…Leishmaniases are diseases caused by protozoan parasites of the genus Leishmania. Clinically, leishmaniases range from cutaneous to visceral forms, with…”
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Antileishmanial and cytotoxic activities of ionic surfactants compared to those of miltefosine by Alonso, Lais, Cardoso, Éder Jeferson Souza, Gomes, Rodrigo Saar, Mendanha, Sebastião Antônio, Dorta, Miriam Leandro, Alonso, Antonio

“…[Display omitted] •The IC50 of miltefosine on Leishmania was cell-concentration dependent.•Ionic surfactants increased the dynamics of the parasite membrane…”
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Leishmania (Viannia) guyanensis in tegumentary leishmaniasis by Borges, Arissa Felipe, Gomes, Rodrigo Saar, Ribeiro-Dias, Fátima

“…Leishmania (Viannia) guyanensis is a causal agent of American tegumentary leishmaniasis (ATL). This protozoan has been poorly investigated; however, it can…”
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The influence of a copper efflux pump in Histoplasma capsulatum virulence by Moraes, Dayane, Tristão, Gabriel Brum, Rappleye, Chad A., Ray, Stephanie C., Ribeiro‐Dias, Fátima, Gomes, Rodrigo Saar, Assunção, Leandro do Prado, Paccez, Juliano Domiraci, Zancopé‐Oliveira, Rosely Maria, Silva‐Bailão, Mirelle Garcia, Soares, Célia Maria de Almeida, Bailão, Alexandre Melo

“…During the infectious process, pathogenic microorganisms must obtain nutrients from the host in order to survive and proliferate. These nutritional sources…”
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Lipophosphoglycan From Dermotropic New World Leishmania Upregulates Interleukin-32 and Proinflammatory Cytokines Through TLR4 and NOD2 Receptors by Silveira, Murilo Barros, Gomes, Rodrigo Saar, Shio, Marina Tiemi, Rugani, Jeronimo Nunes, Paranaiba, Larissa Ferreira, Soares, Rodrigo Pedro, Ribeiro-Dias, Fátima

“…Interleukin-32 (IL-32) is produced during infection, but the components of the parasite that induce its production are unknown. An important multivirulence…”
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The NOD2 receptor is crucial for immune responses towards New World Leishmania species by dos Santos, Jéssica Cristina, Damen, Michelle S. M. A., Oosting, Marije, de Jong, Dirk J., Heinhuis, Bas, Gomes, Rodrigo Saar, Araújo, Carla Santos, Netea, Mihai G., Ribeiro-Dias, Fátima, Joosten, Leo A. B.

“…American Tegumentary Leishmaniasis is a chronic infection caused by Leishmania protozoan. It is not known whether genetic variances in NOD-like receptor (NLR)…”
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Cytokines and microbicidal molecules regulated by IL-32 in THP-1-derived human macrophages infected with New World Leishmania species by Dos Santos, Jéssica Cristina, Heinhuis, Bas, Gomes, Rodrigo Saar, Damen, Michelle S M A, Real, Fernando, Mortara, Renato A, Keating, Samuel T, Dinarello, Charles A, Joosten, Leo A B, Ribeiro-Dias, Fátima

“…Interleukin-32 (IL-32) is expressed in lesions of patients with American Tegumentary Leishmaniasis (ATL), but its precise role in the disease remains unknown…”
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Leishmania (Viannia) braziliensis amastigotes induces the expression of TNFα and IL-10 by human peripheral blood mononuclear cells in vitro in a TLR4-dependent manner by Galdino, Hélio, Saar Gomes, Rodrigo, dos Santos, Jessica Cristina, Pessoni, Lívia Lara, Maldaner, Anetícia Eduarda, Marques, Stéfanne Madalena, Gomes, Clayson Moura, Dorta, Miriam Leandro, de Oliveira, Milton Adriano Pelli, Joosten, Leo A.B., Ribeiro-Dias, Fátima

“…•L. braziliensis amastigotes induce TNFα and IL-10 in IFNγ-primed PBMCs.•Induction of TNFα and IL-10 by L. braziliensis amastigotes is dependent on TLR4.•TLR4…”
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Platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with Leishmania (Viannia) braziliensis by Borges, Arissa Felipe, Morato, Camila Imai, Gomes, Rodrigo Saar, Dorta, Miriam Leandro, de Oliveira, Milton Adriano Pelli, Ribeiro-Dias, Fátima

“…Abstract Platelet-activating factor (PAF) is produced by macrophages during inflammation and infections. We evaluated whether PAF is able to modulate the…”
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IL-32γ promotes the healing of murine cutaneous lesions caused by Leishmania braziliensis infection in contrast to Leishmania amazonensis by Gomes, Rodrigo Saar, Silva, Muriel Vilela Teodoro, Dos Santos, Jéssica Cristina, de Lima Silva, Lucas Luiz, Batista, Aline Carvalho, Machado, Juliana Reis, Teixeira, Mauro Martins, Dorta, Miriam Leandro, de Oliveira, Milton Adriano Pelli, Dinarello, Charles A, Joosten, Leo A B, Ribeiro-Dias, Fátima

“…Interleukin 32 (IL-32) is a pro-inflammatory cytokine induced in patients with American tegumentary leishmaniasis (ATL) caused by Leishmania braziliensis…”
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Alterations in monocyte subsets and cytokine production after TLR activation in American Cutaneous Leishmaniasis by Quixabeira, Valéria Bernadete Leite, Pereira, Ledice Inacia de Araújo, Veras, Poliana Ribeiro Valadares, da Costa, Ana Carolina Vieira, Fonseca, Larissa Gomides, Galdino Jr, Hélio, da Silva Jr, Ildefonso Alves, Morato, Camila Imai, Pinto, Sebastião Alves, Pereira, Ana Joaquina Cohen Serique, Dorta, Miriam Leandro, Oliveira, Milton Adriano Pelli de, Gomes, Rodrigo Saar, Ribeiro‐Dias, Fátima

“…Phenotypic and functional aspects of monocytes from Localized Cutaneous Leishmaniasis (LCL) patients were evaluated. The frequencies of monocyte subsets and…”
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Characterization of T Helper 1 and 2 Cytokine Profiles in Newborns of Mothers with COVID-19 by Moreira, André Luís Elias, Silva, Paulo Alex Neves da, Gomes, Rodrigo Saar, Santos, Mônica de Oliveira, Ito, Célia Regina Malveste, Barbosa, Lucas Candido Gonçalves, Souza, Paula Pires de, Peixoto, Fernanda Aparecida de Oliveira, Wastowski, Isabela Jubé, Carneiro, Lilian Carla, Avelino, Melissa Ameloti Gomes

“…An infectious disease caused by SARS-CoV-2, COVID-19 greatly affects the pediatric population and is 3 times more prevalent in newborns than in the general…”
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The influence of ecto-nucleotidases on Leishmania amazonensis infection and immune response in C57B/6 mice by de Souza, Miriam Conceição, de Assis, Elisângela Aparecida, Gomes, Rodrigo Saar, Marques da Silva, Eduardo de Almeida, Melo, Maria Norma, Fietto, Juliana Lopes Rangel, Afonso, Luís Carlos Crocco

“…Reduced infectivity of Leishmania amazonensis due to prolonged in vitro culture is associated with decreased ecto-nucleotidase activity and altered immune…”
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AVALIAÇÃO DE FATORES QUE IMPACTAM NA INCIDÊNCIA DE RECIDIVAS DE LEISHMANIOSE TEGUMENTAR OU LEISHMANIOSE VISCERAL EM PACIENTES CO-INFECTADOS COM O VÍRUS DA IMUNODEFICIÊNCIA HUMANA by Araújo, Camila Freire, Oliveira, Iara Barreto Neves, Silva, Muriel Vilela Teodoro, Pereira, Ledice Inácia de Araújo, Pinto, Sebastião Alves, Silveira, Murilo Barros, Dorta, Miriam Leandro, Fonseca, Simone Gonçalves, Gomes, Rodrigo Saar, Ribeiro-Dias, Fátima

“…A Leishmaniose tegumentar (LT) e a leishmaniose visceral (LV) são doenças endêmicas que emergiram como doenças oportunistas em pessoas vivendo com o vírus da…”
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Comparative EPR spectroscopy analysis of amphotericin B and miltefosine interactions with Leishmania, erythrocyte and macrophage membranes by Alonso, Lais, Mendanha, Sebastião Antônio, Gomes, Rodrigo Saar, Dorta, Miriam Leandro, Alonso, Antonio

“…•Amphotericin B (AmB) reduced the membrane probe dynamics in Leishmania parasite.•AmB membrane concentration was assessed in terms of its antiproliferative…”
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Single nucleotide polymorphisms in genes involved in immune responses and outcome of tegumentary leishmaniasis by Oliveira, Iara Barreto Neves, Borges, Clayton Luiz, Gomes, Rodrigo Saar, Ribeiro-Dias, Fátima

“…•Polymorphisms in the host immune response genes influence the pathogenesis and/or control of leishmaniasis.•Tegumentary leishmaniasis (TL) is a disease of the…”
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Antileishmanial activity of the chalcone derivative LQFM064 associated with reduced fluidity in the parasite membrane as assessed by EPR spectroscopy by Alonso, Lais, Menegatti, Ricardo, Gomes, Rodrigo Saar, Dorta, Miriam Leandro, Luzin, Rangel Magalhães, Lião, Luciano Morais, Alonso, Antonio

“…•LQFM064 causes cell membrane rigidity, as detected by EPR spectroscopy.•EPR spectroscopy suggests that LQFM064 causes peroxidation of membrane…”
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In vitro antileishmanial and cytotoxic activities of nerolidol are associated with changes in plasma membrane dynamics by Alonso, Lais, Fernandes, Kelly Souza, Mendanha, Sebastião Antônio, Gonçalves, Pablo José, Gomes, Rodrigo Saar, Dorta, Miriam Leandro, Alonso, Antonio

“…The sesquiterpene nerolidol is a membrane-active compound that has demonstrated antitumor, antibacterial, antifungal and antiparasitic activities. In this…”
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