Search Results - "Saal, Lao H"

Serial monitoring of circulating tumor DNA in patients with primary breast cancer for detection of occult metastatic disease by Olsson, Eleonor, Winter, Christof, George, Anthony, Chen, Yilun, Howlin, Jillian, Tang, Man‐Hung Eric, Dahlgren, Malin, Schulz, Ralph, Grabau, Dorthe, van Westen, Danielle, Fernö, Mårten, Ingvar, Christian, Rose, Carsten, Bendahl, Pär‐Ola, Rydén, Lisa, Borg, Åke, Gruvberger‐Saal, Sofia K, Jernström, Helena, Saal, Lao H

“…Metastatic breast cancer is usually diagnosed after becoming symptomatic, at which point it is rarely curable. Cell‐free circulating tumor DNA (ctDNA) contains…”
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Clinical associations of ESR2 (estrogen receptor beta) expression across thousands of primary breast tumors by Dalal, Hina, Dahlgren, Malin, Gladchuk, Sergii, Brueffer, Christian, Gruvberger-Saal, Sofia K., Saal, Lao H.

“…Estrogen receptor alpha (ERα, encoded by ESR1 ) is a well-characterized transcription factor expressed in more than 75% of breast tumors and is the key…”
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Serum selenium, selenoprotein P and glutathione peroxidase 3 as predictors of mortality and recurrence following breast cancer diagnosis: A multicentre cohort study by Demircan, Kamil, Bengtsson, Ylva, Sun, Qian, Brange, Annie, Vallon-Christersson, Johan, Rijntjes, Eddy, Malmberg, Martin, Saal, Lao H., Rydén, Lisa, Borg, Åke, Manjer, Jonas, Schomburg, Lutz

“…The trace element selenium is of essential importance for the synthesis of a set of redox active proteins. We investigated three complementary serum selenium…”
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Features of increased malignancy in eosinophilic clear cell renal cell carcinoma by Nilsson, Helén, Lindgren, David, Axelson, Håkan, Brueffer, Christian, Saal, Lao H, Lundgren, Jaana, Johansson, Martin E

“…Clear cell renal cell carcinoma (ccRCC) is the most common form of renal cancer. Due to inactivation of the von Hippel–Lindau tumour suppressor, the…”
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NF1‐mutated melanoma tumors harbor distinct clinical and biological characteristics by Cirenajwis, Helena, Lauss, Martin, Ekedahl, Henrik, Törngren, Therese, Kvist, Anders, Saal, Lao H., Olsson, Håkan, Staaf, Johan, Carneiro, Ana, Ingvar, Christian, Harbst, Katja, Hayward, Nicholas K., Jönsson, Göran

“…In general, melanoma can be considered as a UV‐driven disease with an aggressive metastatic course and high mutational load, with only few tumors (acral,…”
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The mutational landscape of the SCAN‐B real‐world primary breast cancer transcriptome by Brueffer, Christian, Gladchuk, Sergii, Winter, Christof, Vallon‐Christersson, Johan, Hegardt, Cecilia, Häkkinen, Jari, George, Anthony M, Chen, Yilun, Ehinger, Anna, Larsson, Christer, Loman, Niklas, Malmberg, Martin, Rydén, Lisa, Borg, Åke, Saal, Lao H

“…Breast cancer is a disease of genomic alterations, of which the panorama of somatic mutations and how these relate to subtypes and therapy response is…”
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p53 Maintains Baseline Expression of Multiple Tumor Suppressor Genes by Pappas, Kyrie, Xu, Jia, Zairis, Sakellarios, Resnick-Silverman, Lois, Abate, Francesco, Steinbach, Nicole, Ozturk, Sait, Saal, Lao H, Su, Tao, Cheung, Pamela, Schmidt, Hank, Aaronson, Stuart, Hibshoosh, Hanina, Manfredi, James, Rabadan, Raul, Parsons, Ramon

“…is the most commonly mutated tumor suppressor gene and its mutation drives tumorigenesis. Using ChIP-seq for p53 in the absence of acute cell stress, we found…”
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Activation of the PI3K Pathway in Cancer Through Inhibition of PTEN by Exchange Factor P-REX2a by Fine, Barry, Hodakoski, Cindy, Koujak, Susan, Su, Tao, Saal, Lao H, Maurer, Matthew, Hopkins, Benjamin, Keniry, Megan, Sulis, Maria Luisa, Mense, Sarah, Hibshoosh, Hanina, Parsons, Ramon

“…PTEN (phosphatase and tensin homolog on chromosome 10) is a tumor suppressor whose cellular regulation remains incompletely understood. We identified…”
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Proteomic profiling reveals that ESR1 mutations enhance cyclin-dependent kinase signaling by De Marchi, Tommaso, Lai, Chun-Fui, Simmons, Georgia M., Goldsbrough, Isabella, Harrod, Alison, Lam, Thai, Buluwela, Lakjaya, Kjellström, Sven, Brueffer, Christian, Saal, Lao H., Malmström, Johan, Ali, Simak, Niméus, Emma

“…Three quarters of all breast cancers express the estrogen receptor (ER, ESR1 gene), which promotes tumor growth and constitutes a direct target for endocrine…”
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Poor prognosis in carcinoma is associated with a gene expression signature of aberrant PTEN tumor suppressor pathway activity by Saal, Lao H, Johansson, Peter, Holm, Karolina, Gruvberger-Saal, Sofia K, She, Qing-Bai, Maurer, Matthew, Koujak, Susan, Ferrando, Adolfo A, Malmström, Per, Memeo, Lorenzo, Isola, Jorma, Bendahl, Pär-Ola, Rosen, Neal, Hibshoosh, Hanina, Ringnér, Markus, Borg, Åke, Parsons, Ramon

“…Pathway-specific therapy is the future of cancer management. The oncogenic phosphatidylinositol 3-kinase (PI3K) pathway is frequently activated in solid…”
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Mitochondrial heteroplasmic shifts reveal a positive selection of breast cancer by Li, Yanni, Sundquist, Kristina, Vats, Sakshi, Hong, Mun-Gwan, Wang, Xiao, Chen, Yilun, Hedelius, Anna, Saal, Lao H, Sundquist, Jan, Memon, Ashfaque A

“…Abstract Background Breast cancer is, despite screening, not always detected early enough and is together with other tumor types known to shed genetic…”
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CD44 isoforms are heterogeneously expressed in breast cancer and correlate with tumor subtypes and cancer stem cell markers by Olsson, Eleonor, Honeth, Gabriella, Bendahl, Pär-Ola, Saal, Lao H, Gruvberger-Saal, Sofia, Ringnér, Markus, Vallon-Christersson, Johan, Jönsson, Göran, Holm, Karolina, Lövgren, Kristina, Fernö, Mårten, Grabau, Dorthe, Borg, Ake, Hegardt, Cecilia

“…The CD44 cell adhesion molecule is aberrantly expressed in many breast tumors and has been implicated in the metastatic process as well as in the putative…”
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Matched analysis of circulating selenium with the breast cancer selenotranscriptome: a multicentre prospective study by Demircan, Kamil, Bengtsson, Ylva, Chillon, Thilo Samson, Vallon-Christersson, Johan, Sun, Qian, Larsson, Christer, Malmberg, Martin, Saal, Lao H., Rydén, Lisa, Borg, Åke, Manjer, Jonas, Schomburg, Lutz

“…Abstract Introduction Low serum selenium and altered tumour RNA expression of certain selenoproteins are associated with a poor breast cancer prognosis…”
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Serum copper, zinc and copper/zinc ratio in relation to survival after breast cancer diagnosis: A prospective multicenter cohort study by Bengtsson, Ylva, Demircan, Kamil, Vallon-Christersson, Johan, Malmberg, Martin, Saal, Lao H., Rydén, Lisa, Borg, Åke, Schomburg, Lutz, Sandsveden, Malte, Manjer, Jonas

“…The essential trace elements copper and zinc, and their ratio (copper/zinc), are important for maintaining redox homeostasis. Previous studies suggest that…”
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Expression of functional toll like receptor 4 in estrogen receptor/progesterone receptor-negative breast cancer by Mehmeti, Meliha, Allaoui, Roni, Bergenfelz, Caroline, Saal, Lao H, Ethier, Stephen P, Johansson, Martin E, Jirström, Karin, Leandersson, Karin

“…Toll-like receptors (TLRs) are a family of pattern recognition receptors that are expressed on cells of the innate immune system. The ligands can be pathogen…”
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CITED1 as a marker of favourable outcome in anti-endocrine treated, estrogen-receptor positive, lymph-node negative breast cancer by Dahlgren, Malin, Lettiero, Barbara, Dalal, Hina, Mårtensson, Kira, Gaber, Alexander, Nodin, Björn, Gruvberger-Saal, Sofia K, Saal, Lao H, Howlin, Jillian

“…To investigate CITED1 as a potential biomarker of anti-endocrine response and breast cancer recurrence, given its previously determined role in mediating…”
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Global H3K27 trimethylation and EZH2 abundance in breast tumor subtypes by Holm, Karolina, Grabau, Dorthe, Lövgren, Kristina, Aradottir, Steina, Gruvberger-Saal, Sofia, Howlin, Jillian, Saal, Lao H., Ethier, Stephen P., Bendahl, Pär-Ola, Stål, Olle, Malmström, Per, Fernö, Mårten, Rydén, Lisa, Hegardt, Cecilia, Borg, Åke, Ringnér, Markus

“…Polycomb repressive complex 2 (PRC2) and its core member enhancer of zeste homolog 2 (EZH2) mediate the epigenetic gene silencing mark: trimethylation of…”
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Autoimmunity to selenoprotein P predicts breast cancer recurrence by Demircan, Kamil, Sun, Qian, Bengtsson, Ylva, Seemann, Petra, Vallon-Christersson, Johan, Malmberg, Martin, Saal, Lao H., Rydén, Lisa, Minich, Waldemar B., Borg, Åke, Manjer, Jonas, Schomburg, Lutz

“…Low concentrations of serum selenium (Se) and its main transporter selenoprotein P (SELENOP) are associated with a poor prognosis following breast cancer…”
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BioArray Software Environment (BASE): a platform for comprehensive management and analysis of microarray data by Saal, Lao H, Troein, Carl, Vallon-Christersson, Johan, Gruvberger, Sofia, Borg, Ake, Peterson, Carsten

“…The microarray technique requires the organization and analysis of vast amounts of data. These data include information about the samples hybridized, the…”
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Molecular and genetic diversity in the metastatic process of melanoma by Harbst, Katja, Lauss, Martin, Cirenajwis, Helena, Winter, Christof, Howlin, Jillian, Törngren, Therese, Kvist, Anders, Nodin, Björn, Olsson, Eleonor, Häkkinen, Jari, Jirström, Karin, Staaf, Johan, Lundgren, Lotta, Olsson, Håkan, Ingvar, Christian, Gruvberger-Saal, Sofia K, Saal, Lao H, Jönsson, Göran

“…Diversity between metastatic melanoma tumours in individual patients is known; however, the molecular and genetic differences remain unclear. To examine the…”
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