Search Results - "Saal, L. H."

Estrogen receptor status in breast cancer is associated with remarkably distinct gene expression patterns by Gruvberger, S, Ringnér, M, Chen, Y, Panavally, S, Saal, L H, Borg A, Fernö, M, Peterson, C, Meltzer, P S

“…To investigate the phenotype associated with estrogen receptor alpha (ER) expression in breast carcinoma, gene expression profiles of 58 node-negative breast…”
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Targeted sequencing of BRCA1 and BRCA2 across a large unselected breast cancer cohort suggests that one-third of mutations are somatic by Winter, C., Nilsson, M.P., Olsson, E., George, A.M., Chen, Y., Kvist, A., Törngren, T., Vallon-Christersson, J., Hegardt, C., Häkkinen, J., Jönsson, G., Grabau, D., Malmberg, M., Kristoffersson, U., Rehn, M., Gruvberger-Saal, S.K., Larsson, C., Borg, Å., Loman, N., Saal, L.H.

“…A mutation found in the BRCA1 or BRCA2 gene of a breast tumor could be either germline or somatically acquired. The prevalence of somatic BRCA1/2 mutations and…”
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Minimizing inequality in access to precision medicine in breast cancer by real‐time population‐based molecular analysis in the SCAN‐B initiative by Rydén, L., Loman, N., Larsson, C., Hegardt, C., Vallon‐Christersson, J., Malmberg, M., Lindman, H., Ehinger, A., Saal, L. H., Borg, Å.

“…Background Selection of systemic therapy for primary breast cancer is currently based on clinical biomarkers along with stage. Novel genomic tests are…”
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Classification and diagnostic prediction of cancers using gene expression profiling and artificial neural networks by Khan, Javed, Meltzer, Paul S, Wei, Jun S, Ringnér, Markus, Saal, Lao H, Ladanyi, Marc, Westermann, Frank, Berthold, Frank, Schwab, Manfred, Antonescu, Cristina R, Peterson, Carsten

“…The purpose of this study was to develop a method of classifying cancers to specific diagnostic categories based on their gene expression signatures using…”
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Duplex Sequencing Uncovers Recurrent Low‐frequency Cancer‐associated Mutations in Infant and Childhood KMT2A‐rearranged Acute Leukemia by Pilheden, Mattias, Ahlgren, Louise, Hyrenius‐Wittsten, Axel, Gonzalez‐Pena, Veronica, Sturesson, Helena, Hansen Marquart, Hanne Vibeke, Lausen, Birgitte, Castor, Anders, Pronk, Cornelis Jan, Barbany, Gisela, Pokrovskaja Tamm, Katja, Fogelstrand, Linda, Lohi, Olli, Norén‐Nyström, Ulrika, Asklin, Johanna, Chen, Yilun, Song, Guangchun, Walsh, Michael, Ma, Jing, Zhang, Jinghui, Saal, Lao H., Gawad, Charles, Hagström‐Andersson, Anna K.

“…Infant acute lymphoblastic leukemia (ALL) with KMT2A‐gene rearrangements (KMT2A‐r) have few mutations and a poor prognosis. To uncover mutations that are below…”
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cDNA Microarrays Detect Activation of a Myogenic Transcription Program by the PAX3-FKHR Fusion Oncogene by Khan, Javed, Bittner, Michael L., Saal, Lao H., Teichmann, Ulrike, Azorsa, David O., Gooden, Gerald C., Pavan, William J., Trent, Jeffrey M., Meltzer, Paul S.

“…Alveolar rhabdomyosarcoma is an aggressive pediatric cancer of striated muscle characterized in 60% of cases by a t(2;13)(q35;q14). This results in the fusion…”
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Expression profiling in cancer using cDNA microarrays by Khan, Javed, Saal, Lao H., Bittner, Michael L., Chen, Yidong, Trent, Jeffrey M., Meltzer, Paul S.

“…Currently there are over 1000000 human expressed sequence tag (EST) sequences available on the public database, representing perhaps 50‐90% of all human genes…”
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Features of increased malignancy in eosinophilic clear cell renal cell carcinoma by Nilsson, Helén, Lindgren, David, Axelson, Håkan, Brueffer, Christian, Saal, Lao H, Lundgren, Jaana, Johansson, Martin E

“…Clear cell renal cell carcinoma (ccRCC) is the most common form of renal cancer. Due to inactivation of the von Hippel–Lindau tumour suppressor, the…”
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Comparison of RNA‐ and DNA‐based methods for measurable residual disease analysis in NPM1‐mutated acute myeloid leukemia by Pettersson, Louise, Johansson Alm, Sofie, Almstedt, Alvar, Chen, Yilun, Orrsjö, Gustav, Shah‐Barkhordar, Giti, Zhou, Li, Kotarsky, Heike, Vidovic, Karina, Asp, Julia, Lazarevic, Vladimir, Saal, Lao H., Fogelstrand, Linda, Ehinger, Mats

“…Introduction Reverse transcriptase quantitative PCR (RT‐qPCR) is considered the method of choice for measurable residual disease (MRD) assessment in…”
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Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling by Roswall, Pernilla, Bocci, Matteo, Bartoschek, Michael, Li, Hong, Kristiansen, Glen, Jansson, Sara, Lehn, Sophie, Sjölund, Jonas, Reid, Steven, Larsson, Christer, Eriksson, Pontus, Anderberg, Charlotte, Cortez, Eliane, Saal, Lao H, Orsmark-Pietras, Christina, Cordero, Eugenia, Haller, Bengt Kristian, Häkkinen, Jari, Burvenich, Ingrid J G, Lim, Elgene, Orimo, Akira, Höglund, Mattias, Rydén, Lisa, Moch, Holger, Scott, Andrew M, Eriksson, Ulf, Pietras, Kristian

“…Paracrine signaling networks in the breast cancer microenvironment uncover determinants of hormone receptor status and offer opportunities for therapeutic…”
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Comprehensive molecular comparison of BRCA1 hypermethylated and BRCA1 mutated triple negative breast cancers by Glodzik, Dominik, Bosch, Ana, Hartman, Johan, Aine, Mattias, Vallon-Christersson, Johan, Reuterswärd, Christel, Karlsson, Anna, Mitra, Shamik, Niméus, Emma, Holm, Karolina, Häkkinen, Jari, Hegardt, Cecilia, Saal, Lao H., Larsson, Christer, Malmberg, Martin, Rydén, Lisa, Ehinger, Anna, Loman, Niklas, Kvist, Anders, Ehrencrona, Hans, Nik-Zainal, Serena, Borg, Åke, Staaf, Johan

“…Homologous recombination deficiency (HRD) is a defining characteristic in BRCA -deficient breast tumors caused by genetic or epigenetic alterations in key…”
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Molecular stratification of metastatic melanoma using gene expression profiling: Prediction of survival outcome and benefit from molecular targeted therapy by Cirenajwis, Helena, Ekedahl, Henrik, Lauss, Martin, Harbst, Katja, Carneiro, Ana, Enoksson, Jens, Rosengren, Frida, Werner-Hartman, Linda, Törngren, Therese, Kvist, Anders, Fredlund, Erik, Bendahl, Pär-Ola, Jirström, Karin, Lundgren, Lotta, Howlin, Jillian, Borg, Åke, Gruvberger-Saal, Sofia K, Saal, Lao H, Nielsen, Kari, Ringnér, Markus, Tsao, Hensin, Olsson, Håkan, Ingvar, Christian, Staaf, Johan, Jönsson, Göran

“…Melanoma is currently divided on a genetic level according to mutational status. However, this classification does not optimally predict prognosis. In prior…”
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PIK3CA mutations correlate with hormone receptors, node metastasis, and ERBB2, and are mutually exclusive with PTEN loss in human breast carcinoma by SAAL, Lao H, HOLM, Karolina, HIBSHOOSH, Hanina, BORG, Ake, PARSONS, Ramon, MAURER, Matthew, MEMEO, Lorenzo, TAO SU, XIAOMEI WANG, YU, Jennifer S, MALMSTRÖM, Per-Olof, MANSUKHANI, Mahesh, ENOKSSON, Jens

“…Deregulation of the phosphatidylinositol 3-kinase (PI3K) pathway either through loss of PTEN or mutation of the catalytic subunit alpha of PI3K (PIK3CA) occurs…”
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Abstract P3-02-02: Concordance between immunohistochemical and gene-expression based subtyping of early breast cancer using core needle biopsies and surgical specimens - experices from SCAN-B by Morgan, G, Larsson, C, Tahin, B, Vallon-Christersson, J, Häkkinen, J, Ehinger, A, Malmberg, M, Hegardt, C, Borg, Å, Rydén, L, Saal, LH, Hedenfalk, I, Loman, N

“…Abstract Introduction: Preoperative chemotherapy in early breast cancer increases the rate of breast preservation and provides prognostic information…”
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Abstract P1-06-01: Putting multigene signatures to the test: Prognostic assessment in population-based contemporary clinical breast cancer by Staaf, J, Vallon-Christersson, J, Häkkinen, J, Saal, LH, Hegardt, C, Larsson, C, Ehinger, A, Ryden, L, Loman, N, Malmberg, M, Borg, Å

“…Abstract Background Gene expression signatures hold promise for a molecularly driven division of primary breast cancer with clinical implications. A gap still…”
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Abstract P4-09-03: On the development and clinical value of RNA-sequencing-based classifiers for prediction of the five conventional breast cancer biomarkers: A report from the population-based multicenter SCAN-B study by Brueffer, C, Vallon-Christersson, J, Grabau, D, Ehinger, A, Häkkinen, J, Hegardt, C, Malina, J, Chen, Y, Bendahl, P-O, Manjer, J, Malmberg, M, Larsson, C, Loman, N, Ryden, L, Borg, Å, Saal, LH

“…Abstract Background: In early breast cancer, five histopathological biomarkers are part of current clinical routines and used for determining prognosis and…”
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Abstract P2-02-09: Breast cancer subtype distribution and circulating tumor DNA in response to neoadjuvant chemotherapy: Experiences from a preoperative cohort within SCAN-B by Loman, N, Chen, Y, Aaltonen, K, Brueffer, C, George, AM, Zander, L, Vallon-Christersson, J, Häkkinen, J, Förnvik, D, Rigo, R, Ehinger, A, Malmberg, M, Larsson, C, Hegardt, C, Borg, Å, Rydén, L, Saal, LH

“…Abstract Introduction: Preoperative chemotherapy in early breast cancer increases the rate of breast preservation and provides prognostic information. In the…”
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Abstract P1-07-17: The SCAN-B study: 5-year summary of a large-scale population-based prospective breast cancer translational genomics platform covering a wide geography of Sweden (NCT02306096) by Saal, LH, Hegardt, C, Vallon-Christersson, J, Häkkinen, J, Ehinger, A, Manjer, J, Larsson, C, Loman, N, Rydén, L, Malmberg, M, Borg, Å

“…Abstract Background: Breast cancer exhibits significant molecular, pathological, and clinical heterogeneity. Current clinicopathological evaluation is…”
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Germline mutations in BRCA1 and BRCA2 incidentally revealed in a biobank research study: experiences from re-contacting mutation carriers and relatives by Nilsson, Martin P., Emmertz, Monica, Kristoffersson, Ulf, Borg, Åke, Larsson, Christer, Rehn, Martin, Winter, Christof, Saal, Lao H., Brandberg, Yvonne, Loman, Niklas

“…Once an incidental finding (IF) is discovered in the course of genomic research, the researchers are faced with the question of whether or not that finding…”
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P3-06-08: SCAN-B: An Accelerated Translational Pipeline from Profile to Prognosis and Prediction for Individual Breast Cancer Patients by Loman, N, Saal, LH, Häkkinen, J, Vallon-Christersson, J, Ringnér, M, Hegardt, C, Jönsson, G, Gruvberger-Saal, SK, Kvist, A, Reuterswärd, C, Schulz, R, Karlsson, A, Jönsson, M, Grabau, D, Manjer, J, Carlson, J, Malina, J, Larsson, C, Rydén, L, Borg, Å

“…Abstract The South Sweden Cancerome Analysis Network - Breast (SCAN-B) Initiative is a multidisciplinary network of clinical providers of breast cancer (BC)…”
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