Search Results - "Saadiq, Ishran"

IL-10 partly mediates the ability of MSC-derived extracellular vesicles to attenuate myocardial damage in experimental metabolic renovascular hypertension by Jiang, Yamei, Hong, Siting, Zhu, Xiangyang, Zhang, Lei, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Huang, Weijun, Lerman, Amir, Eirin, Alfonso, Lerman, Lilach O

“…Extracellular vesicles (EVs) obtain properties of immunomodulation and tissue repair from their parental mesenchymal stem cells (MSCs), and upon delivery may…”
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Renovascular disease induces mitochondrial damage in swine scattered tubular cells by Nargesi, Arash Aghajani, Zhu, Xiang-Yang, Conley, Sabena M, Woollard, John R, Saadiq, Ishran M, Lerman, Lilach O, Eirin, Alfonso

“…Scattered tubular-like cells (STCs) contribute to repair neighboring injured renal tubular cells. Mitochondria mediate STC biology and function but might be…”
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Mesenchymal stem cells protect renal tubular cells via TSG-6 regulating macrophage function and phenotype switching by Zhao, Yu, Zhu, Xiang-Yang, Song, Turun, Zhang, Lei, Eirin, Alfonso, Conley, Sabena, Tang, Hui, Saadiq, Ishran, Jordan, Kyra, Lerman, Amir, Lerman, Lilach O

“…Tumor necrosis factor (TNF)-α-induced gene/protein (TSG)-6 regulates the immunomodulatory properties of mesenchymal stem cells (MSCs), but its ability to…”
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Coexisting renal artery stenosis and metabolic syndrome magnifies mitochondrial damage, aggravating poststenotic kidney injury in pigs by Nargesi, Arash Aghajani, Zhang, Lihong, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Textor, Stephen C, Lerman, Lilach O, Eirin, Alfonso

“…OBJECTIVE:Renovascular disease (RVD) produces chronic underperfusion of the renal parenchyma and progressive ischemic injury. Metabolic abnormalities often…”
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Human Obesity Induces Dysfunction and Early Senescence in Adipose Tissue-Derived Mesenchymal Stromal/Stem Cells by Conley, Sabena M, Hickson, LaTonya J, Kellogg, Todd A, McKenzie, Travis, Heimbach, Julie K, Taner, Timucin, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Woollard, John R, Isik, Busra, Afarideh, Mohsen, Tchkonia, Tamar, Kirkland, James L, Lerman, Lilach O

“…Chronic inflammatory conditions like obesity may adversely impact the biological functions underlying the regenerative potential of mesenchymal stromal/stem…”
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Obesity blunts amelioration of cardiac hypertrophy and fibrosis by human mesenchymal stem/stromal cell-derived extracellular vesicles by Hong, Siting, Huang, Weijun, Zhu, Xiangyang, Tang, Hui, Krier, James D, Xing, Li, Lu, Bo, Gandhi, Deep, Jordan, Kyra L, Saadiq, Ishran M, Lerman, Amir, Eirin, Alfonso, Lerman, Lilach O

“…Renovascular hypertension (RVH) can induce cardiac damage that is reversible using adipose tissue-derived mesenchymal stromal/stem cells (A-MSCs). However,…”
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Extracellular vesicles released by adipose tissue-derived mesenchymal stromal/stem cells from obese pigs fail to repair the injured kidney by Eirin, Alfonso, Ferguson, Christopher M., Zhu, Xiang-Yang, Saadiq, Ishran M., Tang, Hui, Lerman, Amir, Lerman, Lilach O.

“…•Metabolic syndrome modifies the cargo of stem cell-derived extracellular vesicles.•Vesicles contain microRNAs that target angiogenic pathways in recipient…”
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Metabolic syndrome increases senescence-associated micro-RNAs in extracellular vesicles derived from swine and human mesenchymal stem/stromal cells by Li, Yongxin, Meng, Yu, Zhu, Xiangyang, Saadiq, Ishran M, Jordan, Kyra L, Eirin, Alfonso, Lerman, Lilach O

“…The metabolic syndrome (MetS) is a combination of cardiovascular risk-factors, including obesity, hypertension, hyperglycemia, and insulin resistance. MetS may…”
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Renovascular Hypertension Induces Myocardial Mitochondrial Damage, Contributing to Cardiac Injury and Dysfunction in Pigs With Metabolic Syndrome by Nargesi, Arash Aghajani, Farah, Mohamed C, Zhu, Xiang-Yang, Zhang, Lei, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Lerman, Amir, Lerman, Lilach O, Eirin, Alfonso

“…Abstract BACKGROUND Renovascular hypertension (RVH) often manifest with metabolic syndrome (MetS) as well. Coexisting MetS and hypertension increases…”
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Low-Energy Shockwave Treatment Promotes Endothelial Progenitor Cell Homing to the Stenotic Pig Kidney by Zhao, Yu, Santelli, Adrian, Zhu, Xiang-Yang, Zhang, Xin, Woollard, John R., Chen, Xiao-Jun, Jordan, Kyra L., Krier, James, Tang, Hui, Saadiq, Ishran, Lerman, Amir, Lerman, Lilach O.

“…Endothelial progenitor cells (EPCs) patrols the circulation and contributes to endothelial cell regeneration. Atherosclerotic renal artery stenosis (ARAS)…”
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Diabetic kidney disease alters the transcriptome and function of human adipose-derived mesenchymal stromal cells but maintains immunomodulatory and paracrine activities important for renal repair by Hickson, LaTonya J, Eirin, Alfonso, Conley, Sabena M, Taner, Timucin, Bian, Xiaohui, MBBCh, Ahmed Saad, Herrmann, Sandra M, Mehta, Ramila A, McKenzie, Travis J, Kellogg, Todd A, Kirkland, James L, Tchkonia, Tamar, Saadiq, Ishran M, Tang, Hui, Jordan, Kyra L, Zhu, Xiangyang, MBBCh, Mathew D Griffin, Rule, Andrew D, van Wijnen, Andre J, Textor, Stephen C, Lerman, Lilach O

“…Mesenchymal stem/stromal cells (MSC) facilitate repair in experimental diabetic kidney disease (DKD). However, the hyperglycemic and uremic milieu may diminish…”
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Effect of Hypoxia Preconditioning on the Regenerative Capacity of Adipose Tissue Derived Mesenchymal Stem Cells in a Model of Renal Artery Stenosis by Farooqui, Naba, Mohan, Arjunmohan, Isik, Busra, Goksu, Busra B, Thaler, Roman, Zhu, Xiang Yang, Krier, James D, Saadiq, Ishran M, Ferguson, Christopher M, Jordan, Kyra L, Tang, Hui, Textor, Stephen C, Hickson, La Tonya J, van Wijnen, Andre J, Eirin, Alfonso, Lerman, Lilach O, Herrmann, Sandra M

“…Atherosclerotic renal artery stenosis (ARAS) is associated with irreversible parenchymal renal disease and regenerative stem cell therapies may improve renal…”
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Microvascular remodeling and altered angiogenic signaling in human kidneys distal to occlusive atherosclerotic renal artery stenosis by Klomjit, Nattawat, Zhu, Xiang-Yang, Eirin, Alfonso, Pawar, Aditya S, Conley, Sabena M, Puranik, Amrutesh S, Ferguson, Christopher M, Kim, Seo Rin, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, Lerman, Amir, Grande, Joseph P, Textor, Stephen C, Lerman, Lilach O

“…Renal artery stenosis (RAS) is an important cause of chronic kidney disease and secondary hypertension. In animal models, renal ischemia leads to…”
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Global epigenetic alterations of mesenchymal stem cells in obesity: the role of vitamin C reprogramming by Afarideh, Mohsen, Thaler, Roman, Khani, Farzaneh, Tang, Hui, Jordan, Kyra L., Conley, Sabena M., Saadiq, Ishran M., Obeidat, Yasin, Pawar, Aditya S., Eirin, Alfonso, Zhu, Xiang-Yang, Lerman, Amir, van Wijnen, Andre J., Lerman, Lilach O.

“…Obesity promotes dysfunction and impairs the reparative capacity of mesenchymal stem/stromal cells (MSCs), and alters their transcription, protein content, and…”
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Experimental Renovascular Disease Induces Endothelial Cell Mitochondrial Damage and Impairs Endothelium-Dependent Relaxation of Renal Artery Segments by Nargesi, Arash Aghajani, Zhu, Xiang-Yang, Saadiq, Ishran M, Jordan, Kyra L, Lerman, Amir, Lerman, Lilach O, Eirin, Alfonso

“…Abstract BACKGROUND Mitochondria modulate endothelial cell (EC) function, but may be damaged during renal disease. We hypothesized that the ischemic and…”
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The impact of hypoxia preconditioning on mesenchymal stem cells performance in hypertensive kidney disease by Sohi, Gurparneet Kaur, Farooqui, Naba, Mohan, Arjunmohan, Rajagopalan, Kamalnath Sankaran, Xing, Li, Zhu, Xiang Y, Jordan, Kyra, Krier, James D, Saadiq, Ishran M, Tang, Hui, Hickson, LaTonya J, Eirin, Alfonso, Lerman, Lilach O, Herrmann, Sandra M

“…Autologous mesenchymal stem cells (MSCs) have emerged as a therapeutic option for many diseases. Hypertensive kidney disease (HKD) might impair MSCs'…”
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Hypoxic preconditioning induces epigenetic changes and modifies swine mesenchymal stem cell angiogenesis and senescence in experimental atherosclerotic renal artery stenosis by Isik, Busra, Thaler, Roman, Goksu, Busra B, Conley, Sabena M, Al-Khafaji, Hayder, Mohan, Arjunmohan, Afarideh, Mohsen, Abumoawad, Abdelrhman M, Zhu, Xiang Y, Krier, James D, Saadiq, Ishran M, Tang, Hui, Eirin, Alfonso, Hickson, LaTonya J, van Wijnen, Andre J, Textor, Stephen C, Lerman, Lilach O, Herrmann, Sandra M

“…Atherosclerotic renal artery stenosis (ARAS) is a risk factor for ischemic and hypertensive kidney disease (HKD) for which autologous mesenchymal stem cell…”
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Percutaneous transluminal renal angioplasty attenuates poststenotic kidney mitochondrial damage in pigs with renal artery stenosis and metabolic syndrome by Farahani, Rahele A., Afarideh, Mohsen, Zhu, Xiang‐Yang, Tang, Hui, Jordan, Kyra L., Saadiq, Ishran M., Ferguson, Christopher M., Lerman, Amir, Textor, Stephen C., Lerman, Lilach O., Eirin, Alfonso

“…Percutaneous transluminal renal angioplasty (PTRA) has been used to treat renovascular disease (RVD), a chronic condition characterized by renal ischemia and…”
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Obesity and dyslipidemia are associated with partially reversible modifications to DNA hydroxymethylation of apoptosis- and senescence-related genes in swine adipose-derived mesenchymal stem/stromal cells by Glasstetter, Logan M, Oderinde, Tomiwa S, Mirchandani, Mohit, Rajagopalan, Kamalnath Sankaran, Barsom, Samer H, Thaler, Roman, Siddiqi, Sarosh, Zhu, Xiang-Yang, Tang, Hui, Jordan, Kyra L, Saadiq, Ishran M, van Wijnen, Andre J, Eirin, Alfonso, Lerman, Lilach O

“…Obesity dysregulates key biological processes underlying the functional homeostasis, fate decisions, and reparative potential of mesenchymal stem/stromal cells…”
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Human liver derived mesenchymal stromal cells ameliorate murine ischemia-induced inflammation through macrophage polarization by Liang, Yun, Ozdogan, Elif, Hansen, Michael J, Tang, Hui, Saadiq, Ishran, Jordan, Kyra L, Krier, James D, Gandhi, Deep B, Grande, Joseph P, Lerman, Lilach O, Taner, Timucin

“…The immunomodulatory properties of mesenchymal stromal cells (MSC) have been well-characterized in and models. We have previously shown that liver MSC (L-MSC)…”
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