Search Results - "Saadeh, M"

Cardiopulmonary Bypass and Oxidative Stress by Angelini, Gianni D., Suleiman, M.-Saadeh, Guida, Gustavo, Zakkar, Mustafa

“…The development of the cardiopulmonary bypass (CPB) revolutionized cardiac surgery and contributed immensely to improved patients outcomes. CPB is associated…”
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Hearts from mice fed a non-obesogenic high-fat diet exhibit changes in their oxidative state, calcium and mitochondria in parallel with increased susceptibility to reperfusion injury by Littlejohns, Ben, Pasdois, Philippe, Duggan, Simon, Bond, Andrew R, Heesom, Kate, Jackson, Christopher L, Angelini, Gianni D, Halestrap, Andrew P, Suleiman, M-Saadeh

“…High-fat diet with obesity-associated co-morbidities triggers cardiac remodeling and renders the heart more vulnerable to ischemia/reperfusion injury. However,…”
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Endothelial glycocalyx is damaged in diabetic cardiomyopathy: angiopoietin 1 restores glycocalyx and improves diastolic function in mice by Qiu, Yan, Buffonge, Stanley, Ramnath, Raina, Jenner, Sophie, Fawaz, Sarah, Arkill, Kenton P., Neal, Chris, Verkade, Paul, White, Stephen J., Hezzell, Melanie, Salmon, Andrew H. J., Suleiman, M.-Saadeh, Welsh, Gavin I., Foster, Rebecca R., Madeddu, Paolo, Satchell, Simon C.

“…Aims/hypothesis Diabetic cardiomyopathy (DCM) is a serious and under-recognised complication of diabetes. The first sign is diastolic dysfunction, which…”
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Cardioprotection of Immature Heart by Simultaneous Activation of PKA and Epac: A Role for the Mitochondrial Permeability Transition Pore by Lewis, Martin John, Khaliulin, Igor, Hall, Katie, Suleiman, M Saadeh

“…Metabolic and ionic changes during ischaemia predispose the heart to the damaging effects of reperfusion. Such changes and the resulting injury differ between…”
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Inhibition of Cardiac RIP3 Mitigates Early Reperfusion Injury and Calcium-Induced Mitochondrial Swelling without Altering Necroptotic Signalling by Horvath, Csaba, Young, Megan, Jarabicova, Izabela, Kindernay, Lucia, Ferenczyova, Kristina, Ravingerova, Tanya, Lewis, Martin, Suleiman, M Saadeh, Adameova, Adriana

“…Receptor-interacting protein kinase 3 (RIP3) is a convergence point of multiple signalling pathways, including necroptosis, inflammation and oxidative stress;…”
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Nrf2-Keap-1 imbalance under acute shear stress induces inflammatory response in venous endothelial cells by Ward, Alexander O, Sala-Newby, Graciela B, Ladak, Shameem, Angelini, Gianni D, Caputo, Massimo, Suleiman, M.-Saadeh, Evans, Paul C, George, Sarah J, Zakkar, Mustafa

“…Vascular endothelial cell stimulation is associated with the activation of different signalling pathways and transcription factors. Acute shear stress is known…”
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Activation of peripheral δ2-opioid receptor prevents reperfusion heart injury by Maslov, Leonid N., Mukhomedzyanov, Alexander V., Tsibulnikov, Sergey Y., Suleiman, M.-Saadeh, Khaliulin, Igor, Oeltgen, Peter R.

“…Coronary artery occlusion (45 min) and reperfusion (2 h) was performed in rats anesthetized with α-chloralose. Opioid receptor agonists were administered…”
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Functional and cardioprotective effects of simultaneous and individual activation of protein kinase A and Epac by Khaliulin, Igor, Bond, Mark, James, Andrew F, Dyar, Zara, Amini, Raheleh, Johnson, Jason L, Suleiman, M‐Saadeh

“…Background and Purpose Myocardial cAMP elevation confers cardioprotection against ischaemia/reperfusion (I/R) injury. cAMP activates two independent signalling…”
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Local Inhibition of MicroRNA-24 Improves Reparative Angiogenesis and Left Ventricle Remodeling and Function in Mice With Myocardial Infarction by Meloni, Marco, Marchetti, Micol, Garner, Kathryn, Littlejohns, Ben, Sala-Newby, Graciela, Xenophontos, Natasa, Floris, Ilaria, Suleiman, M-Saadeh, Madeddu, Paolo, Caporali, Andrea, Emanueli, Costanza

“…Myocardial infarction (MI) is the leading cause of death worldwide. MicroRNAs regulate the expression of their target genes, thus mediating a plethora of…”
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Consecutive Isoproterenol and Adenosine Treatment Confers Marked Protection against Reperfusion Injury in Adult but Not in Immature Heart: A Role for Glycogen by Lewis, Martin, Szobi, Adrian, Balaska, Dirki, Khaliulin, Igor, Adameova, Adriana, Griffiths, Elinor, Orchard, Clive H, Suleiman, M-Saadeh

“…Consecutive treatment of adult rat heart with isoproterenol and adenosine (Iso/Aden), known to consecutively activate PKA/PKC signaling, is cardioprotective…”
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The transcription factor Nrf2 promotes survival by enhancing the expression of uncoupling protein 3 under conditions of oxidative stress by Anedda, Andrea, López-Bernardo, Elia, Acosta-Iborra, Bárbara, Saadeh Suleiman, M., Landázuri, Manuel O., Cadenas, Susana

“…Uncoupling protein 3 (UCP3) is a member of the mitochondrial inner membrane carrier superfamily that modulates energy efficiency by catalyzing proton…”
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Controlled reoxygenation during cardiopulmonary bypass decreases markers of organ damage, inflammation, and oxidative stress in single-ventricle patients undergoing pediatric heart surgery by Caputo, Massimo, MD, Mokhtari, Amir, FRCS, Miceli, Antonio, MD, Ghorbel, Mohamed T., PhD, Angelini, Gianni D., FRCS, Parry, Andrew J., FRCS, Suleiman, Saadeh M., DSc

“…Objective Single-ventricle patients undergoing pediatric heart surgery are a high-risk group owing to reoxygenation injury during cardiopulmonary bypass (CPB)…”
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Interplay of Oxidative Stress and Necrosis-like Cell Death in Cardiac Ischemia/Reperfusion Injury: A Focus on Necroptosis by Adameova, Adriana, Horvath, Csaba, Abdul-Ghani, Safa, Varga, Zoltan V, Suleiman, M Saadeh, Dhalla, Naranjan S

“…Extensive research work has been carried out to define the exact significance and contribution of regulated necrosis-like cell death program, such as…”
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The relationship of atrial fibrillation with left atrial size in patients with essential hypertension by Saadeh, Rami, Abu Jaber, Bara, Alzuqaili, Taqwa, Ghura, Sara, Al-ajlouny, Taiba, Saadeh, Abdallah M.

“…Atrial fibrillation (AF) is the most common sustained arrhythmia and it is a major public health problem worldwide. Hypertension is one of the major risk…”
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Subacute Reperfusion in Ischemic Hearts: Study of Autophagy and its Possible Interconnection with Receptor-Interacting Protein Kinase 3 by Horváth, Csaba, Ravingerová, Tanya, Suleiman, M Saadeh, Adameová, Adriana

“…The role of cardiac autophagy during ischemia and reperfusion (I/R) remains controversial. Furthermore, whether this cell death during I/R is also…”
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Geostatistical Assessment of Groundwater Nitrate Contamination with Reflection on DRASTIC Vulnerability Assessment: The Case of the Upper Litani Basin, Lebanon by Assaf, H., Saadeh, M.

“…Groundwater constitutes the largest single source of fresh water in many parts of the world and provides a risk buffer to sustain critical water demands during…”
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Preconditioning or Postconditioning with 8-Br-cAMP-AM Protects the Heart against Regional Ischemia and Reperfusion: A Role for Mitochondrial Permeability Transition by Khaliulin, Igor, Ascione, Raimondo, Maslov, Leonid N, Amal, Haitham, Suleiman, M Saadeh

“…The cAMP analogue 8-Br-cAMP-AM (8-Br) confers marked protection against global ischaemia/reperfusion of isolated perfused heart. We tested the hypothesis that…”
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Neuro-autonomic changes induced by remote ischemic preconditioning (RIPC) in healthy young adults: Implications for stress by Khaliulin, Igor, Fleishman, Arnold N., Shumeiko, Nadezhda I., Korablina, TatyanaV, Petrovskiy, Stanislav A., Ascione, Raimondo, Suleiman, M.-Saadeh

“…The mechanisms underlying the protective effects of remote ischemic preconditioning (RIPC) are not presently clear. Recent studies in experimental models…”
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Efficacy of propofol-supplemented cardioplegia on biomarkers of organ injury in patients having cardiac surgery using cardiopulmonary bypass: A protocol for a randomised controlled study (ProMPT2) by Heys, Rachael, Angelini, Gianni D, Joyce, Katherine, Smartt, Helena, Culliford, Lucy, Maishman, Rachel, de Jesus, Samantha E, Emanueli, Costanza, Suleiman, M-Saadeh, Punjabi, Prakash, Rogers, Chris A, Gibbison, Ben

“…Introduction Cardiac surgery with cardiopulmonary bypass and cardioplegic arrest is known to be responsible for ischaemia and reperfusion organ injury. In a…”
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Remote ischemic conditioning: from experimental observation to clinical application: report from the 8th Biennial Hatter Cardiovascular Institute Workshop by Pickard, Jack M. J., Bøtker, Hans Erik, Crimi, Gabriele, Davidson, Brian, Davidson, Sean M., Dutka, David, Ferdinandy, Peter, Ganske, Rocky, Garcia-Dorado, David, Giricz, Zoltan, Gourine, Alexander V., Heusch, Gerd, Kharbanda, Rajesh, Kleinbongard, Petra, MacAllister, Raymond, McIntyre, Christopher, Meybohm, Patrick, Prunier, Fabrice, Redington, Andrew, Robertson, Nicola J., Suleiman, M. Saadeh, Vanezis, Andrew, Walsh, Stewart, Yellon, Derek M., Hausenloy, Derek J.

“…In 1993, Przyklenk and colleagues made the intriguing experimental observation that ‘brief ischemia in one vascular bed also protects remote, virgin myocardium…”
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