Search Results - "Saad, Muhammed A"

Aberrations of miR-126-3p, miR-181a and sirtuin1 network mediate Di-(2-ethylhexyl) phthalate-induced testicular damage in rats: The protective role of hesperidin by Helmy, Hebatullah S., Senousy, Mahmoud A., El-Sahar, Ayman E., Sayed, Rabab H., Saad, Muhammed A., Elbaz, Eman M.

“…[Display omitted] •Administration of DEHP induced testicular damage and toxicity in rats.•DEHP disturbed spermatogenesis and testicular redox state.•DEHP…”
Get full text

Peganum harmala enhanced GLP-1 and restored insulin signaling to alleviate AlCl3-induced Alzheimer-like pathology model by Saleh, Rofida A., Eissa, Tarek F., Abdallah, Dalaal M., Saad, Muhammed A., El-Abhar, Hanan S.

“…Peganum harmala ( P. harmala ) is a folk medicinal herb used in the Sinai Peninsula (Egypt) as a remedy for central disorders. The main constituents, harmine…”
Get full text

Dapagliflozin diminishes memory and cognition impairment in Streptozotocin induced diabetes through its effect on Wnt/β-Catenin and CREB pathway by El-Safty, Hala, Ismail, Ashraf, Abdelsalam, Rania M., El-Sahar, Ayman E., Saad, Muhammed A.

“…Diabetic neuropathy is a chronic condition that affects a significant number of individuals with diabetes. Streptozotocin injection intraperitoneally to…”
Get full text

Stimulation of Autophagy by Dapagliflozin Mitigates Cadmium-Induced Testicular Dysfunction in Rats: The Role of AMPK/mTOR and SIRT1/Nrf2/HO-1 Pathways by Arab, Hany H, Fikry, Ebtehal Mohammad, Alsufyani, Shuruq E, Ashour, Ahmed M, El-Sheikh, Azza A K, Darwish, Hany W, Al-Hossaini, Abdullah M, Saad, Muhammed A, Al-Shorbagy, Muhammad Y, Eid, Ahmed H

“…Cadmium (Cd) is a widespread environmental pollutant that triggers testicular dysfunction. Dapagliflozin is a selective sodium-glucose co-transporter-2…”
Get full text

Targeting Autophagy, Apoptosis, and SIRT1/Nrf2 Axis with Topiramate Underlies Its Neuroprotective Effect against Cadmium-Evoked Cognitive Deficits in Rats by Arab, Hany H, Eid, Ahmed H, Yahia, Rania, Alsufyani, Shuruq E, Ashour, Ahmed M, El-Sheikh, Azza A. K, Darwish, Hany W, Saad, Muhammed A, Al-Shorbagy, Muhammad Y, Masoud, Marwa A

“…Cadmium is an environmental toxicant that instigates cognitive deficits with excessive glutamate excitatory neuroactivity in the brain. Topiramate, a glutamate…”
Get full text

Activation of autophagy and suppression of apoptosis by dapagliflozin attenuates experimental inflammatory bowel disease in rats: Targeting AMPK/mTOR, HMGB1/RAGE and Nrf2/HO-1 pathways by Arab, Hany H., Al-Shorbagy, Muhammad Y., Saad, Muhammed A.

“…Dapagliflozin, a selective sodium-glucose co-transporter 2 (SGLT2) inhibitor, has featured marked anti-inflammatory effects in murine models of myocardial…”
Get full text

Dapagliflozin improves behavioral dysfunction of Huntington's disease in rats via inhibiting apoptosis-related glycolysis by El-Sahar, Ayman E., Rastanawi, Alyasaa A., El-Yamany, Muhammed F., Saad, Muhammed A.

“…Huntington's disease is a rare neurodegenerative disorder which is associated with defected glucose metabolism with consequent behavioral disturbance including…”
Get full text

Inosine attenuates 3-nitropropionic acid-induced Huntington's disease-like symptoms in rats via the activation of the A2AR/BDNF/TrKB/ERK/CREB signaling pathway by El-Shamarka, Marwa El-Sayed, El-Sahar, Ayman E., Saad, Muhammed A., Assaf, Naglaa, Sayed, Rabab H.

“…Huntington's disease (HD) is an autosomal dominant inherited neurodegenerative disease characterized by involuntary bizarre movements, psychiatric symptoms,…”
Get full text

Neuroprotective effects of vildagliptin on drug induced Alzheimer's disease in rats with metabolic syndrome: Role of hippocampal klotho and AKT signaling pathways by Yossef, Rasha R., Al-Yamany, Mohamed F., Saad, Muhammed A., El-Sahar, Ayman E.

“…Growing evidences suggest the presence of several similarities in the molecular mechanisms underlying the neurodegenerative diseases and metabolic…”
Get full text

Neuroprotective effect of nebivolol against cisplatin‐associated depressive‐like behavior in rats by Abdelkader, Noha F., Saad, Muhammed A., Abdelsalam, Rania M.

“…One‐third of cancer patients undergoing chemotherapy treatment often display symptoms of depression leading to poor adherence and decreased quality of life…”
Get full text

Roflumilast ameliorates ovariectomy-induced depressive-like behavior in rats via activation of AMPK/mTOR/ULK1-dependent autophagy pathway by Zaki, Eman S., Sayed, Rabab H., Saad, Muhammed A., El-Yamany, Muhammed F.

“…Roflumilast, a well-known phosphodiesterase-4 (PDE-4) inhibitor, possess an anti-inflammatory activity with approved indications in chronic obstructive…”
Get full text

Mechanistic perspective of morin protection against ketoprofen-induced gastric mucosal injury: Targeting HMGB1/RAGE/NF-κB, DJ-1/Nrf2/HO-1 and PI3K/mTOR pathways by Arab, Hany H., Saad, Muhammed A., El-Sahar, Ayman E., Al-Shorbagy, Muhammad Y.

“…Ketoprofen is a widely used NSAID which incurs gastric mucosal damage. The high mobility group Box 1 (HMGB1) protein is a DNA-binding protein which exerts…”
Get full text

Linagliptin ameliorates acetic acid-induced colitis via modulating AMPK/SIRT1/PGC-1α and JAK2/STAT3 signaling pathway in rats by El-Ghannam, Mohamed S., Saad, Muhammed A., Nassar, Noha N., El-Yamany, Muhammad Farag, El-Bahy, Alshaymaa A.Z.

“…Ulcerative colitis is a chronic inflammatory disease, profoundly affecting the patient's quality of life and is associated with various complications…”
Get full text

Dulaglutide impedes depressive-like behavior persuaded by chronic social defeat stress model in male C57BL/6 mice: Implications on GLP-1R and cAMP/PKA signaling pathway in the hippocampus by Darwish, Amal B., El Sayed, Nesrine S., Salama, Abeer A.A., Saad, Muhammed A.

“…There is a well-founded relation between bullying and depression, which may eventually lead to suicidal behavior. Repurposing of antidiabetic drugs for the…”
Get full text

Targeting the TLR4/NF-κΒ Axis and NLRP1/3 Inflammasomes by Rosuvastatin: A Role in Impeding Ovariectomy-Induced Cognitive Decline Neuropathology in Rats by Saad, Muhammed A., Al-Shorbagy, Muhammad Y., Arab, Hany H.

“…Postmenopausal hormone-related cognitive decline has gained an immense interest to explore the underlying mechanisms and potential therapies. The current work…”
Get full text

Farnesyl pyrophosphate synthase inhibitors with antiosteoporosis efficacy in ovariectomized rats: A mixed binding approach beyond bisphosphonates by El- Sayed, Naglaa F., El-Hussieny, Marwa, Mansour, Shaimaa T., Fouad, Marwa A., Saad, Muhammed A., Ewies, Ewies F.

“…The primary focus of bisphosphonate medications is on targeting human farnesyl pyrophosphate synthase (hFPPS), an essential regulator of mammalian isoprenoids…”
Get full text

Dapoxetine attenuates testosterone-induced prostatic hyperplasia in rats by the regulation of inflammatory and apoptotic proteins by Sayed, Rabab H., Saad, Muhammed A., El-Sahar, Ayman E.

“…Serotonin level plays a role in suppressing the pathological findings of benign prostatic hyperplasia (BPH). Thus a new selective serotonin reuptake inhibitor,…”
Get full text

Ascorbic acid Mitigates behavioural disturbances associated with letrozole-induced PCOS via switching-off JAK2/STAT5 and JAK2/ERK1/2 pathways in rat hippocampus by Saad, Muhammed A., Rastanawi, Alyasaa A., El-Sahar, Ayman E., A. Z. El-Bahy, Alshaymaa

“…•Letrozole induced PCOS with relevant histopathological alterations in rats.•Letrozole-induced injury involves hormonal, metabolic and anti-oxidative…”
Get full text

Nano-ivabradine averts behavioral anomalies in Huntington's disease rat model via modulating Rhes/m-tor pathway by Saad, Muhammed A., Ahmed, Maha A.E., Elbadawy, Norhan N., Abdelkader, Noha F.

“…Huntington's disease (HD) is characterized by abnormal involuntary movements together with cognitive impairment and disrupted mood changes. 3-nitropropionic…”
Get full text

Natural angiotensin converting enzyme inhibitors: A safeguard against hypertension, respiratory distress syndrome, and chronic kidney diseases by Khaled, Aya, Ahmed, Esraa, Mamdouh, Mohamed, Saad, Hager, Mohamed, Aya, Sobhy, Marina, Piatti, Diletta, Sabry, Miral, Saad, Muhammed A., Sabry, Omar M., Caprioli, Giovanni

“…Hypertension is a serious concern as it is one of the causes of kideny failure and pulmonary fibrosis. An important therapeutic strategy for treating chronic…”
Get full text