Search Results - "Saad, MJA"

Liraglutide modulates gut microbiota and reduces NAFLD in obese mice by Moreira, GV, Azevedo, FF, Ribeiro, LM, Santos, A, Guadagnini, D, Gama, P, Liberti, EA, Saad, MJA, Carvalho, CRO

“…Metabolic disorders such as insulin resistance and diabetes are associated with obesity and nonalcoholic fatty liver disease (NAFLD). The aggressive form of a…”
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Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice by Carvalho, B. M., Guadagnini, D., Tsukumo, D. M. L., Schenka, A. A., Latuf-Filho, P., Vassallo, J., Dias, J. C., Kubota, L. T., Carvalheira, J. B. C., Saad, M. J. A.

“…Aims/hypothesis A high-fat dietary intake induces obesity and subclinical inflammation, which play important roles in insulin resistance. Recent studies have…”
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Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus by De Souza, Cláudio T, Araujo, Eliana P, Bordin, Silvana, Ashimine, Rika, Zollner, Ricardo L, Boschero, Antonio C, Saad, Mário J. A, Velloso, Lício A

“…Obesity has reached epidemic proportions in several regions of the world. General changes in lifestyle, including consumption of fat-rich food, are among the…”
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Lack of insulin inhibition on insulin secretion in non-diabetic morbidly obese patients by MUSCELLI, E, PEREIRA, J. A, LAZARIN, Mact, DA SILVA, Ca, PAREJA, J. C, SAAD, M. J. A

“…Insulin inhibition of insulin secretion has been described in normal lean subjects. In this study, we examined whether this phenomenon also occurs in the…”
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Anti-inflammatory, procollagen, and wound repair properties of topical insulin gel by Apolinário, P P, Zanchetta, F C, Breder, J S C, Adams, G, Consonni, S R, Gillis, R, Saad, M J A, Lima, M H M

“…Diabetes mellitus is associated with impaired wound healing. The topical use of insulin is a promising therapy because it may favor all phases of the wound…”
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AdipoR1 mediates the anorexigenic and insulin/leptin-like actions of adiponectin in the hypothalamus by Coope, Andressa, Milanski, Marciane, Araújo, Eliana P., Tambascia, Marcos, Saad, Mário J.A., Geloneze, Bruno, Velloso, Lício A.

“…Adiponectin exerts an insulin-sensitizing effect, improving insulin action in peripheral tissues and restraining insulin resistance. Here, we explore the…”
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S-nitrosation of the insulin receptor, insulin receptor substrate 1, and protein kinase B/Akt : A novel mechanism of insulin resistance by CARVALHO-FILHO, Marco A, UENO, Mirian, HIRABARA, Sandro M, SEABRA, Amedea B, CARVAIHEIRA, José B. C, DE OLIVEIRA, Marcelo G, VELLOSO, Licio A, CURI, Rui, SAAD, Mario J. A

“…Evidence demonstrates that exogenous nitric oxide (NO) and the NO produced by inducible nitric oxide synthase (iNOS) can induce insulin resistance in muscle…”
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Enhancement of cellular activity in hyperglycemic mice dermal wounds dressed with chitosan-alginate membranes by Breder, J S C, Pires, A L R, Azevedo, F F, Apolinário, P P, Cantaruti, T, Jiwani, S I, Moraes, Â M, Consonni, S R, Araújo, E P, Adams, G G, Saad, M J A, Lima, M H M

“…The use of specially designed wound dressings could be an important alternative to facilitate the healing process of wounds in the hyperglycemic state…”
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Regulation of insulin signalling by hyperinsulinaemia : role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway by UENO, M, CARVALHEIRA, J. B. C, TAMBASCIA, R. C, BEZERRA, R. M. N, AMARAL, M. E, CARNEIRO, E. M, FOLLI, F, FRANCHINI, K. G, SAAD, M. J. A

“…Several epidemiological studies have suggested an association between chronic hyperinsulinaemia and insulin resistance. However, the causality of this…”
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The multi-faceted cross-talk between the insulin and angiotensin II signaling systems by Velloso, Licio A., Folli, Franco, Perego, Lucia, Saad, Mario J. A.

“…Insulin and angiotensin II are hormones that play pivotal roles in the control of two vital and closely related systems, the metabolic and the circulatory…”
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Cross-talk between the insulin and leptin signaling systems in rat hypothalamus by Carvalheira, J.B.C, Torsoni, M.A, Ueno, M, Amaral, M.E, Araujo, E.P, Velloso, L.A, Gontijo, J.A.R, Saad, M.J.A

“…Objective: To investigate whether insulin and leptin share common intracellular signal transduction pathways and to determine whether these hormonal signaling…”
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Probiotic pretreatment improves survival and prevents gut mucosal barrier dysfunction in sepsis by Calisto, KL, Camacho, ACAP, Mittestainer, FC, Mendes, MCS, Santos, AC, Saad, MJA

“…Keywords: Intestinal Permeability, Lactobacillus Acidophilus, Probiotic Treatment, Bifidobacterium Longum, Lactobacillus Bulgaricus…”
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Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats by CARVALHEIRA, J. B. C, RIBEIRO, E. B, ARAUJO, E. P, GUIMARAES, R. B, TELLES, M. M, TORSONI, M, GONTIJO, J. A. R, VELLOSO, L. A, SAAD, M. J. A

“…By acting in the brain, insulin suppresses food intake. However, little is known with regard to insulin signalling in the hypothalamus in insulin-resistant…”
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Increased expression of advanced glycation end-products and their receptor, and activation of nuclear factor kappa-B in lacrimal glands of diabetic rats by Alves, M, Calegari, V. C, Cunha, D. A, Saad, M. J. A, Velloso, L. A, Rocha, E. M

“…Aims/hypothesis To assess the involvement of the AGE-specific receptor (AGER, also known as RAGE) axis and nuclear factor kappa-B (NFKB, also known as…”
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Identification of Insulin in the Tear Film and Insulin Receptor and IGF-I Receptor on the Human Ocular Surface by Rocha, Eduardo M, Cunha, Daniel A, Carneiro, Everardo M, Boschero, Antonio C, Saad, Mario J. A, Velloso, Licio A

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Cross-Talk between the Insulin and Angiotensin Signaling Systems by Velloso, Licio A., Folli, Franco, Sun, Xiao J., White, Morris F., Mario J. A. Saad, Kahn, C. Ronald

“…Angiotensin II (AII), acting via its G-protein linked receptor, is an important regulator of cardiac, vascular, and renal function. Following injection of AII…”
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Novel Signal Transduction Pathway for Luteinizing Hormone and Its Interaction with Insulin: Activation of Janus Kinase/Signal Transducer and Activator of Transcription and Phosphoinositol 3-Kinase/Akt Pathways by Carvalho, Carla R. O, Carvalheira, José B. C, Lima, Maria H. M, Zimmerman, Suzana F, Caperuto, Luciana C, Amanso, Angélica, Gasparetti, Alessandra L, Meneghetti, Vainer, Zimmerman, Leonardo F, Velloso, Licio A, Saad, Mario J. A

“…The actions of LH are mediated through a single class of cell surface LH/human chorionic gonadotropin receptor, which is a member of the G protein-coupled…”
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Early Activation of the Multicomponent Signaling Complex Associated With Focal Adhesion Kinase Induced by Pressure Overload in the Rat Heart by Franchini, Kleber G, Torsoni, Adriana S, Soares, Paulo H. A, Saad, Mario J. A

“…Mechanical overload elicits functional and structural adaptive mechanisms in cardiac muscle. Signaling pathways linked to integrin/cytoskeleton complexes may…”
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A high fructose diet affects the early steps of insulin action in muscle and liver of rats by Bezerra, R M, Ueno, M, Silva, M S, Tavares, D Q, Carvalho, C R, Saad, M J

“…A high fructose diet induces insulin resistance in rats, although the exact molecular mechanism involved is unknown. In this study, we used immunoprecipitation…”
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Insulin modulates leptin-induced STAT3 activation in rat hypothalamus by Carvalheira, José B.C., Siloto, Rodrigo M.P., Ignacchitti, Inara, Brenelli, Sigisfredo L., Carvalho, Carla R.O., Leite, Adilson, Velloso, Lı́cio A., Gontijo, José A.R., Saad, Mario J.A.

“…Insulin and leptin have overlapping effects in the control of energy homeostasis, but the molecular basis of this synergism is unknown. Insulin signals through…”
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