Search Results - "Saad, M J"

Linking Gut Microbiota and Inflammation to Obesity and Insulin Resistance by Saad, M J A, Santos, A, Prada, P O

“…Obesity and insulin resistance are the major predisposing factors to comorbidities, such as Type 2 diabetes, nonalcoholic fatty liver disease, cardiovascular…”
Get full text

Modulation of gut microbiota by antibiotics improves insulin signalling in high-fat fed mice by Carvalho, B. M., Guadagnini, D., Tsukumo, D. M. L., Schenka, A. A., Latuf-Filho, P., Vassallo, J., Dias, J. C., Kubota, L. T., Carvalheira, J. B. C., Saad, M. J. A.

“…Aims/hypothesis A high-fat dietary intake induces obesity and subclinical inflammation, which play important roles in insulin resistance. Recent studies have…”
Get full text

Obesity enhances eosinophilic inflammation in a murine model of allergic asthma by Calixto, MC, Lintomen, L, Schenka, A, Saad, MJ, Zanesco, A, Antunes, E

“…Background and purpose:  Obesity is associated with deterioration in asthma outcomes. Although airways eosinophil accumulation is characteristic of lung…”
Get full text

Distinct regulation of hypothalamic and brown/beige adipose tissue activities in human obesity by Rachid, B, van de Sande-Lee, S, Rodovalho, S, Folli, F, Beltramini, G C, Morari, J, Amorim, B J, Pedro, T, Ramalho, A F, Bombassaro, B, Tincani, A J, Chaim, E, Pareja, J C, Geloneze, B, Ramos, C D, Cendes, F, Saad, M J A, Velloso, L A

“…Background/Objectives: The identification of brown/beige adipose tissue in adult humans has motivated the search for methods aimed at increasing its…”
Get full text

Pioglitazone treatment increases food intake and decreases energy expenditure partially via hypothalamic adiponectin/adipoR1/AMPK pathway by Quaresma, P G F, Reencober, N, Zanotto, T M, Santos, A C, Weissmann, L, de Matos, A H B, Lopes-Cendes, I, Folli, F, Saad, M J A, Prada, P O

“…Introduction: Thiazolidinediones (TZDs) enhanced body weight (BW) partially by increased adipogenesis and hyperphagia. Neuronal PPARγ knockout mice on high-fat…”
Get full text

Atorvastatin and diacerein reduce insulin resistance and increase disease tolerance in rats with sepsis by da Silva, K L C, Camacho, A P, Mittestainer, F C, Carvalho, B M, Santos, A, Guadagnini, D, Oliveira, A G, Saad, M J A

“…Sepsis is one of the leading causes of death among hospitalized patients. At the onset of this condition, there is an over-production of pro-inflammatory…”
Get full text

Nuclear factor-κB and advanced glycation end-products expression in lacrimal glands of aging rats by Alves, M, Cunha, D Andrade, Calegari, V Cristine, Saad, M J A, Boschero, A Carlos, Velloso, L Augusto, Rocha, E Melani

Get full text

Regulation of insulin signalling by hyperinsulinaemia : role of IRS-1/2 serine phosphorylation and the mTOR/p70 S6K pathway by UENO, M, CARVALHEIRA, J. B. C, TAMBASCIA, R. C, BEZERRA, R. M. N, AMARAL, M. E, CARNEIRO, E. M, FOLLI, F, FRANCHINI, K. G, SAAD, M. J. A

“…Several epidemiological studies have suggested an association between chronic hyperinsulinaemia and insulin resistance. However, the causality of this…”
Get full text

l-glutamine supplementation induces insulin resistance in adipose tissue and improves insulin signalling in liver and muscle of rats with diet-induced obesity by Prada, P. O, Hirabara, S. M, Souza, C. T. de, Schenka, A. A, Zecchin, H. G, Vassallo, J, Velloso, L. A, Carneiro, E, Carvalheira, J. B. C, Curi, R, Saad, M. J

“…Aims/hypothesis Diet-induced obesity (DIO) is associated with insulin resistance in liver and muscle, but not in adipose tissue. Mice with fat-specific…”
Get full text

Selective impairment of insulin signalling in the hypothalamus of obese Zucker rats by CARVALHEIRA, J. B. C, RIBEIRO, E. B, ARAUJO, E. P, GUIMARAES, R. B, TELLES, M. M, TORSONI, M, GONTIJO, J. A. R, VELLOSO, L. A, SAAD, M. J. A

“…By acting in the brain, insulin suppresses food intake. However, little is known with regard to insulin signalling in the hypothalamus in insulin-resistant…”
Get full text

Increased expression of advanced glycation end-products and their receptor, and activation of nuclear factor kappa-B in lacrimal glands of diabetic rats by Alves, M, Calegari, V. C, Cunha, D. A, Saad, M. J. A, Velloso, L. A, Rocha, E. M

“…Aims/hypothesis To assess the involvement of the AGE-specific receptor (AGER, also known as RAGE) axis and nuclear factor kappa-B (NFKB, also known as…”
Get full text

Modulation in insulin receptor, insulin receptor substrate-1, and phosphatidylinositol 3-kinase in liver and muscle of dexamethasone-treated rats by SAAD, M. J. A, FOLLI, F, KAHN, J. A, KAHN, C. R

“…Insulin rapidly stimulates tyrosine kinase activity of its receptor resulting in phosphorylation of its cytosolic substrate, insulin receptor substrate-1…”
Get full text

Insulin signalling pathways in aorta and muscle from two animal models of insulin resistance: the obese middle-aged and the spontaneously hypertensive rats by ZECCHIN, H. G, BEZERRA, R. M. N, CARVALHEIRA, J. B. C, CARVALHO-FILHO, M. A, METZE, K, FRANCHINI, K. G, SAAD, M. J. A

“…The aim of this study was to investigate insulin signalling pathways directly in vivo in skeletal muscle and thoracic aorta from obese middle-aged…”
Get full text

Peroxisome proliferator-activated receptor γ coactivator-1-dependent uncoupling protein-2 expression in pancreatic islets of rats: a novel pathway for neural control of insulin secretion by DE SOUZA, C. T, GASPARETTI, A. L, PEREIRA-DA-SILVA, M, ARAUJO, E. P, CARVALHEIRA, J. B, SAAD, M. J. A, BOSCHERO, A. C, CARNEIRO, E. M, VELLOSO, L. A

“…Sympathetic inputs inhibit insulin secretion through alpha2-adrenergic receptors coupled with Gi protein. High adrenergic tonus generated by exposure of…”
Get full text

Circulating ghrelin concentrations are lowered by intracerebroventricular insulin by Ueno, M, Carvalheira, J. B. C, Oliveira, R. L. G. S, Velloso, L. A, Saad, M. J. A

“…Aims/hypothesis Ghrelin is a peptide that is mainly produced by the stomach and stimulates food intake, adiposity and weight gain. Previous studies have…”
Get full text

Modification of oil palm empty fruit bunches with maleic anhydride: The effect on the tensile and dimensional stability properties of empty fruit bunch/polypropylene composites by Rozman, H. D., Saad, M. J., Mohd Ishak, Z. A.

“…Oil palm empty fruit bunch (EFB)‐filled polypropylene (PP) composites were produced. The EFB filler was chemically modified with maleic anhydride (MAH). The…”
Get full text

Flexural and impact properties of oil palm empty fruit bunch (EFB)–polypropylene composites—the effect of maleic anhydride chemical modification of EFB by Rozman, H.D, Saad, M.J, Mohd Ishak, Z.A

“…This study focused on the effect of chemical modification of oil palm empty fruit bunch (EFB) filler on the flexural and impact properties of EFB-filled…”
Get full text

Regulation of phosphatidylinositol 3-kinase activity in liver and muscle of animal models of insulin-resistant and insulin-deficient diabetes mellitus by FOLLI, F, SAAD, M. J. A, BACKER, J. M, KAHN, C. R

“…Insulin stimulates tyrosine phosphorylation of insulin receptor substrate 1 (IRS-1), which in turn binds to and activates phosphatidylinositol 3-kinase (PI…”
Get full text

Metagenomics analysis reveals universal signatures of the intestinal microbiota in colorectal cancer, regardless of regional differences by Berbert, L, Santos, A, Magro, D O, Guadagnini, D, Assalin, H B, Lourenço, L H, Martinez, C A R, Saad, M J A, Coy, C S R

“…The human gut microbiota is a complex and dynamic community of microorganisms living in our intestines and has emerged as an important factor for colorectal…”
Get full text

Regulation of insulin receptor substrate-1 in liver and muscle of animal models of insulin resistance by SAAD, M. J. A, ARAKI, E, MIRALPEIX, M, ROTHENBERG, P. L, WHITE, M. F, KAHN, C. R

“…Insulin rapidly stimulates tyrosine phosphorylation of a protein of approximately 185 kD in most cell types. This protein, termed insulin receptor substrate-1…”
Get full text