Search Results - "Saad, JA"

Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients by Ridker, Paul M, Revkin, James, Amarenco, Pierre, Brunell, Robert, Curto, Madelyn, Civeira, Fernando, Flather, Marcus, Glynn, Robert J, Gregoire, Jean, Jukema, J. Wouter, Karpov, Yuri, Kastelein, John J.P, Koenig, Wolfgang, Lorenzatti, Alberto, Manga, Pravin, Masiukiewicz, Urszula, Miller, Michael, Mosterd, Arend, Murin, Jan, Nicolau, Jose C, Nissen, Steven, Ponikowski, Piotr, Santos, Raul D, Schwartz, Pamela F, Soran, Handrean, White, Harvey, Wright, R. Scott, Vrablik, Michal, Yunis, Carla, Shear, Charles L, Tardif, Jean-Claude

“…In two randomized trials comparing the PCSK9 inhibitor bococizumab with placebo, bococizumab had no benefit with respect to major adverse cardiovascular events…”
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Guideline for stable coronary artery disease by Cesar, L A, Ferreira, J F, Armaganijan, D, Gowdak, L H, Mansur, A P, Bodanese, L C, Sposito, A, Sousa, A C, Chaves, A J, Markman, B, Caramelli, B, Vianna, C B, Oliveira, C C, Meneghetti, C, Albuquerque, D C, Stefanini, E, Nagib, E, Pinto, I M F, Castro, I, Saad, J A, Schneider, J C, Tsutsui, J M, Carneiro, J K R, Torres, K, Piegas, L S, Dallan, L A, Lisboa, L A F, Sampaio, M F, Moretti, M A, Lopes, N H, Coelho, O R, Lemos, P, Santos, R D, Botelho, R, Staico, R, Meneghello, R, Montenegro, S T, Vaz, V D

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Microbiota determines insulin sensitivity in TLR2-KO mice by Guadagnini, Dioze, Rocha, Guilherme Zweig, Santos, Andrey, Assalin, Heloisa Balan, Hirabara, Sandro Massao, Curi, Rui, Oliveira, Alexandre Gabarra, Prada, Patricia O., Saad, Mario J.A.

“…Environmental factors have a key role in the control of gut microbiota and obesity. TLR2 knockout (TLR2−/−) mice in some housing conditions are protected from…”
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A red wine intervention does not modify plasma trimethylamine N-oxide but is associated with broad shifts in the plasma metabolome and gut microbiota composition by Haas, Elisa A, Saad, Mario JA, Santos, Andrey, Vitulo, Nicola, Lemos, Jr, Wilson JF, Martins, Aline MA, Picossi, Carolina RC, Favarato, Desidério, Gaspar, Renato S, Magro, Daniéla O, Libby, Peter, Laurindo, Francisco RM, Da Luz, Protasio L

“…Gut microbiota profiles are closely related to cardiovascular diseases through mechanisms that include the reported deleterious effects of metabolites, such as…”
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Gut microbiota is a key modulator of insulin resistance in TLR 2 knockout mice by Caricilli, Andréa M, Picardi, Paty K, de Abreu, Lélia L, Ueno, Mirian, Prada, Patrícia O, Ropelle, Eduardo R, Hirabara, Sandro Massao, Castoldi, Ângela, Vieira, Pedro, Camara, Niels O S, Curi, Rui, Carvalheira, José B, Saad, Mário J A

“…Environmental factors and host genetics interact to control the gut microbiota, which may have a role in the development of obesity and insulin resistance…”
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Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance by TSUKUMO, Daniela M. L, CARVALHO-FILHO, Marco A, SAAD, Mario J. A, CARVALHEIRA, José B. C, PRADA, Patricia O, HIRABARA, Sandro M, SCHENKA, André A, ARAUJO, Eliana P, VASSALLO, José, CURI, Rui, VELLOSO, Licio A

“…Loss-of-Function Mutation in Toll-Like Receptor 4 Prevents Diet-Induced Obesity and Insulin Resistance Daniela M.L. Tsukumo 1 , Marco A. Carvalho-Filho 1 ,…”
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Oral supplementation with l -glutamine alters gut microbiota of obese and overweight adults: A pilot study by Zambom de Souza, Alessandra Zanin, M.A, Zambom, Adriano Zanin, Ph.D, Abboud, Kahlile Youssef, M.A, Reis, Sabrina Karen, M.A, Tannihão, Fabiana, B.A, Guadagnini, Dioze, M.A, Saad, Mario J.A., Ph.D, Prada, Patricia Oliveira, Ph.D

“…Abstract Objective The aim of this study was to determine whether oral supplementation with l -glutamine (GLN) modifies the gut microbiota composition in…”
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Diretriz de Telecardiologia no Cuidado de Pacientes com Síndrome Coronariana Aguda e Outras Doenças Cardíacas by Oliveira Jr, MT, Canesin, MF, Marcolino, MS, Ribeiro, AL, Carvalho, AC, Reddy, S, Santos, ARF, Fernandes, MAS, Amaral, AZ, Rezende, AC, Nechar Jr, A, Nascimento, BR, Carlos Alberto Pastore, CA, Wen, CL, Gualandro, DM, Napoli, DG, França, FFAC, Feitosa-Filho, GS, Saad, JA, Pilli, J, Paula, LJC, Junqueira, LL, Cesar, LAM, Bodanese, LC, Gutierrez, MA, Alkmim, MBM, Nunes, MB, Medeiros, OO, Moreno, RA, Gundim, RS, Montenegro, ST, Nazima, WI

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Consumption of a Fat-Rich Diet Activates a Proinflammatory Response and Induces Insulin Resistance in the Hypothalamus by De Souza, Cláudio T, Araujo, Eliana P, Bordin, Silvana, Ashimine, Rika, Zollner, Ricardo L, Boschero, Antonio C, Saad, Mário J. A, Velloso, Lício A

“…Obesity has reached epidemic proportions in several regions of the world. General changes in lifestyle, including consumption of fat-rich food, are among the…”
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Physical Exercise Reduces Circulating Lipopolysaccharide and TLR4 Activation and Improves Insulin Signaling in Tissues of DIO Rats by OLIVEIRA, Alexandre G, CARVALHO, Bruno M, TOBAR, Natália, ROPELLE, Eduardo R, PAULI, José R, BAGAROLLI, Renata A, GUADAGNINI, Dioze, CARVALHEIRA, José B. C, SAAD, Mario J. A

“…Insulin resistance in diet-induced obesity (DIO) is associated with a chronic systemic low-grade inflammation, and Toll-like receptor 4 (TLR4) plays an…”
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Tyrosine kinase inhibitors as novel drugs for the treatment of diabetes by Prada, Patricia O, Saad, Mario Ja

“…Some inhibitors of tyrosine kinase, as imatinib, erlotinib and sunitinib have antihyperglycemic effects but the mechanisms are not totally clear. It is well…”
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Climatic Droplet Keratopathy in the Argentine Patagonia by Urrets-Zavalía, Julio A., Knoll, Erna G., Maccio, J. Pablo, Urrets-Zavalía, Enrique A., Saad, José A., Serra, Horacio M.

“…To present the findings of climatic droplet keratopathy (CDK) that affects people of a rural area of the Argentine Patagonia. Observational case series. Five…”
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Delta cell death in the islet of Langerhans and the progression from normal glucose tolerance to type 2 diabetes in non-human primates (baboon, Papio hamadryas) by Guardado Mendoza, Rodolfo, Perego, Carla, Finzi, Giovanna, La Rosa, Stefano, Capella, Carlo, Jimenez-Ceja, Lilia M., Velloso, Licio A., Saad, Mario J. A., Sessa, Fausto, Bertuzzi, Federico, Moretti, Stefania, Dick, Edward J., Davalli, Alberto M., Folli, Franco

“…Aims/hypothesis The cellular composition of the islet of Langerhans is essential to ensure its physiological function. Morphophysiological islet abnormalities…”
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IKKε is key to induction of insulin resistance in the hypothalamus, and its inhibition reverses obesity by Weissmann, Laís, Quaresma, Paula G F, Santos, Andressa C, de Matos, Alexandre H B, Pascoal, Vínicius D'Ávila Bittencourt, Zanotto, Tamires M, Castro, Gisele, Guadagnini, Dioze, da Silva, Joelcimar Martins, Velloso, Licio A, Bittencourt, Jackson C, Lopes-Cendes, Iscia, Saad, Mario J A, Prada, Patricia O

“…IKK epsilon (IKKε) is induced by the activation of nuclear factor-κB (NF-κB). Whole-body IKKε knockout mice on a high-fat diet (HFD) were protected from…”
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Obesity and asthma: beyond T sub(H)2 inflammation by Leiria, Luiz OS, Martins, Milton A, Saad, Mario JA

“…Obesity is a major risk factor for asthma. Likewise, obesity is known to increase disease severity in asthmatic subjects and also to impair the efficacy of…”
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DIRETRIZ DA SOCIEDADE BRASILEIRA DE CARDIOLOGIA E DA SOCIEDADE BRASILEIRA DE HEMODINÂMICA E CARDIOLOGIA INTERVENCIONISTA SOBRE INTERVENÇÃO CORONÁRIA PERCUTÂNEA by Feres, F, Costa, RA, Siqueira, D, Costa Jr, JR, Chamié, D, Staico, R, Chaves, AJ, Abizaid, A, Marin-Neto, JA, Rassi Jr, A, Botelho, R, Alves, CMR, Saad, JA, Mangione, JA, Lemos, PA, Quadros, AS, Queiroga, MAC, Cantarelli, MJC, Figueira, HR

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Double-Stranded RNA-Activated Protein Kinase Is a Key Modulator of Insulin Sensitivity in Physiological Conditions and in Obesity in Mice by Carvalho-Filho, M. A, Carvalho, B. M, Oliveira, A. G, Guadagnini, D, Ueno, M, Dias, M. M, Tsukumo, D. M, Hirabara, S. M, Reis, L. F, Curi, R, Carvalheira, J. B.C, Saad, Mario J.A

“…The molecular integration of nutrient- and pathogen-sensing pathways has become of great interest in understanding the mechanisms of insulin resistance in…”
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Hepatocyte Growth Factor Plays a Key Role in Insulin Resistance-Associated Compensatory Mechanisms by Araújo, Tiago G, Oliveira, Alexandre G, Carvalho, Bruno M, Guadagnini, Dioze, Protzek, André O.P, Carvalheira, Jose B.C, Boschero, Antonio C, Saad, Mario J.A

“…Insulin resistance is present in obesity and in type 2 diabetes and is associated with islet cell hyperplasia and hyperinsulinemia, but the driving forces…”
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A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss by ROPELLE, Eduardo R, PAULI, José R, FRANCHINI, Kleber G, VELLOSO, Licio A, SAAD, Mario J. A, CARVALHEIRA, José B. C, FERNANDES, Maria Fernanda A, ROCCO, Silvana A, MARIN, Rodrigo M, MORARI, Joseane, SOUZA, Kellen K, DIAS, Marilia M, GOMES-MARCONDES, Maria C, GONTIJO, José A. R

“…A Central Role for Neuronal AMP-Activated Protein Kinase (AMPK) and Mammalian Target of Rapamycin (mTOR) in High-Protein Diet–Induced Weight Loss Eduardo R…”
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Oral supplementation withl-glutamine alters gut microbiota of obese and overweight adults: A pilot study by Zambom de Souza, Alessandra Zanin, Zambom, Adriano Zanin, Abboud, Kahlile Youssef, Reis, Sabrina Karen, Tannihão, Fabiana, Guadagnini, Dioze, Saad, Mario JA, Prada, Patricia Oliveira

“…Objective The aim of this study was to determine whether oral supplementation withl-glutamine (GLN) modifies the gut microbiota composition in overweight and…”
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