Search Results - "Saad, Ahmed S."
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Highly sensitive detection of kojic acid in food samples using fluorescent carbon dots derived from pomegranate peel
Published in Scientific reports (10-09-2024)“…Kojic acid (KA) has gained significant attention due to its widespread use in the food and cosmetics industries. However, concerns about its potential…”
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Human mesenchymal stem cell-derived extracellular vesicles/estrogen combined therapy safely ameliorates experimentally induced intrauterine adhesions in a female rat model
Published in Stem cell research & therapy (28-06-2018)“…Mesenchymal stem cells (MSCs) have diverse functions in regulating injury and inflammation through the secretion of extracellular vesicles (EVs). In this…”
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A sustainable approach for the degradation kinetics study and stability assay of the SARS-CoV-2 oral antiviral drug Molnupiravir
Published in Scientific reports (31-05-2023)“…Molnupiravir (MPV) is the first direct-acting oral antiviral drug that effectively decreases nasopharyngeal infections with SARS-CoV-2 virus. The stability of…”
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Quality-by-design ecofriendly potentiometric sensor for rapid monitoring of hydroxychloroquine purity in the presence of toxic impurities
Published in Scientific reports (22-03-2024)“…Hydroxychloroquine (HCQ) is prescribed to treat malaria and certain autoimmune diseases. Recent studies questioned its efficiency in relieving COVID-19…”
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Albendazole-loaded cubosomes interrupt the ERK1/2-HIF-1α-p300/CREB axis in mice intoxicated with diethylnitrosamine: A new paradigm in drug repurposing for the inhibition of hepatocellular carcinoma progression
Published in Biomedicine & pharmacotherapy (01-10-2021)“…Hepatocellular carcinoma (HCC) is a leading cause of cancer related deaths worldwide. It was suggested that albendazole (ABZ) is a powerful inhibitor of…”
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Simultaneous spectrophotometric determination of compounds having relatively disparate absorbance and concentration ranges; application to antidiabetic formulation of linagliptin and metformin
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (05-10-2018)“…The limited linear range of UV–Visible spectrophotometry may be insufficient to occupy multiple components with wide variations in their concentrations or…”
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Comparing the predictability of different chemometric models over UV-spectral data of isoxsuprine and its toxic photothermal degradation products
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (05-08-2019)“…Isoxsuprine (ISX) is widely used for cerebral and peripheral vascular diseases. A comparative study was held among different multivariate calibration models…”
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A Novel Combination Therapy Using Rosuvastatin and Lactobacillus Combats Dextran Sodium Sulfate-Induced Colitis in High-Fat Diet-Fed Rats by Targeting the TXNIP/NLRP3 Interaction and Influencing Gut Microbiome Composition
Published in Pharmaceuticals (Basel, Switzerland) (08-04-2021)“…Inflammasome targeting and controlling dysbiosis are promising therapeutic approaches to control ulcerative colitis. This report is the first to investigate…”
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Evaluation of Synthetic 2,4-Disubstituted-benzo[g]quinoxaline Derivatives as Potential Anticancer Agents
Published in Pharmaceuticals (Basel, Switzerland) (26-08-2021)“…A new series of 2,4-disubstituted benzo[g]quinoxaline molecules have been synthesized, using naphthalene-2,3-diamine and 1,4-dibromonaphthalene-2,3-diamine as…”
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Dual PI3K/Akt Inhibitors Bearing Coumarin-Thiazolidine Pharmacophores as Potential Apoptosis Inducers in MCF-7 Cells
Published in Pharmaceuticals (Basel, Switzerland) (31-03-2022)“…Breast cancer is the most common malignancy worldwide; therefore, the development of new anticancer agents is essential for improved tumor control. By adopting…”
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Acute and Delayed Doxorubicin-Induced Myocardiotoxicity Associated with Elevation of Cardiac Biomarkers, Depletion of Cellular Antioxidant Enzymes, and Several Histopathological and Ultrastructural Changes
Published in Life (Basel, Switzerland) (27-08-2021)“…Doxorubicin (DOX; Adricin) is an anthracycline antibiotic, which is an efficient anticancer chemotherapeutic agent that targets many types of adult and…”
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Experimentally designed electrochemical sensor for therapeutic drug monitoring of Ondansetron co-administered with chemotherapeutic drugs
Published in BMC chemistry (13-10-2022)“…The experimental design extracts valuable information about the main effects and interactions from the least number of experiments. The current work constructs…”
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A smart simple spectrophotometric method for simultaneous determination of binary mixtures
Published in Journal of pharmaceutical analysis (01-10-2012)“…A new simple spectrophotometric method was developed for the simultaneous determination of drugs with interfering spectra in binary mixtures without previous…”
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Bone marrow-derived mesenchymal stem cells combined with gonadotropin therapy restore postnatal oogenesis of chemo-ablated ovaries in rats via enhancing very small embryonic-like stem cells
Published in Stem cell research & therapy (27-09-2021)“…Abstract Background Very small embryonic-like stem cells (VSELs) are a rare population within the ovarian epithelial surface. They contribute to postnatal…”
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Performance enhancement of twisted-bladed Savonius vertical axis wind turbines
Published in Energy conversion and management (01-04-2020)“…•Effects of design parameters on the performance of the Savonius turbine are studied.•The best design is selected based on flow field characteristics around…”
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Performance evaluation of a novel vertical axis wind turbine using twisted blades in multi-stage Savonius rotors
Published in Energy conversion and management (01-05-2021)“…•A new configuration using twisted blades in multi-stage Savonius rotors is developed.•The proposed multi-stage rotors with twisted blades significantly…”
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Solid-state potentiometric sensor for the rapid assay of the biologically active biogenic amine (tyramine) as a marker of food spoilage
Published in Food chemistry (01-06-2021)“…•Optimization of a solid-state potentiometric sensor for Tyramine assay.•Validated sensor for Tyramine assay in different commercial food products.•Fast direct…”
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Novel spectrophotometric method for selective determination of compounds in ternary mixtures (dual wavelength in ratio spectra)
Published in Spectrochimica acta. Part A, Molecular and biomolecular spectroscopy (05-08-2015)“…[Display omitted] •Simple spectrophotometric method for selective determination of ternary mixtures.•No reported spectrophotometric method for the…”
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Computational ionophore selection during optimization of a portable calixarene based sensor for direct assay of levamisole residues in livestock products
Published in Journal of electroanalytical chemistry (Lausanne, Switzerland) (15-09-2021)“…[Display omitted] •Portable solid-state potentiometric sensor for rapid, direct assay of levamisole.•Experimental and computation optimization of the sensor…”
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