Search Results - "Saab, Karim R"

ABCB5 Maintains Melanoma-Initiating Cells through a Proinflammatory Cytokine Signaling Circuit by WILSON, Brian J, SAAB, Karim R, FRANK, Markus H, JIE MA, SCHATTON, Tobias, PÜTZ, Pablo, QIAN ZHAN, MURPHY, George F, GASSER, Martin, WAAGA-GASSER, Ana Maria, FRANK, Natasha Y

“…The drug efflux transporter ABCB5 identifies cancer stem-like cells (CSC) in diverse human malignancies, where its expression is associated with clinical…”
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VEGFR-1 Expressed by Malignant Melanoma- Initiating Cells Is Required for Tumor Growth by FRANK, Natasha Y, SCHATTON, Tobias, WAAGA-GASSER, Ana-Maria, KUPPER, Thomas S, MURPHY, George F, FRANK, Markus H, KIM, Soo, QIAN ZHAN, WILSON, Brian J, JIE MA, SAAB, Karim R, OSHEROV, Veronika, WIDLUND, Hans R, GASSER, Martin

“…Melanoma growth is driven by malignant melanoma-initiating cells (MMIC) identified by expression of the ATP-binding cassette (ABC) member ABCB5. ABCB5(+)…”
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ABCB5 Identifies a Therapy-Refractory Tumor Cell Population in Colorectal Cancer Patients by WILSON, Brian J, SCHATTON, Tobias, MURPHY, George F, FRANK, Markus H, FRANK, Natasha Y, QIAN ZHAN, GASSER, Martin, JIE MA, SAAB, Karim R, SCHANCHE, Robin, WAAGA-GASSER, Ana-Maria, GOLD, Jason S, QIN HUANG

“…Identification and reversal of treatment resistance mechanisms of clinically refractory tumor cells is critical for successful cancer therapy. Here we show…”
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Curcumin potentiates rhabdomyosarcoma radiosensitivity by suppressing NF-κB activity by Orr, W Shannon, Denbo, Jason W, Saab, Karim R, Ng, Catherine Y, Wu, Jianrong, Li, Kui, Garner, Jo Meagan, Morton, Christopher L, Du, Ziyun, Pfeffer, Lawrence M, Davidoff, Andrew M

“…Ionizing radiation (IR) is an essential component of therapy for alveolar rhabdomyosarcoma. Nuclear factor-kappaB (NF-κΒ) transcription factors are upregulated…”
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Tolerance and efficacy of BRAF plus MEK inhibition in patients with melanoma who previously have received programmed cell death protein 1‐based therapy by Saab, Karim R., Mooradian, Meghan J., Wang, Daniel Y., Chon, Jeewon, Xia, Cathy Y., Bialczak, Angelica, Abbate, Kelly T., Menzies, Alexander M., Johnson, Douglas B., Sullivan, Ryan J., Shoushtari, Alexander N.

“…Background Combined BRAF and MEK inhibition (BRAF‐MEK) is a standard therapy for patients with BRAF V600–mutant melanoma, but to the authors’ knowledge, the…”
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ABCB5 is a limbal stem cell gene required for corneal development and repair by Ksander, Bruce R., Kolovou, Paraskevi E., Wilson, Brian J., Saab, Karim R., Guo, Qin, Ma, Jie, McGuire, Sean P., Gregory, Meredith S., Vincent, William J. B., Perez, Victor L., Cruz-Guilloty, Fernando, Kao, Winston W. Y., Call, Mindy K., Tucker, Budd A., Zhan, Qian, Murphy, George F., Lathrop, Kira L., Alt, Clemens, Mortensen, Luke J., Lin, Charles P., Zieske, James D., Frank, Markus H., Frank, Natasha Y.

“…The loss of limbal stem cells (LSCs) due to injury or disease is one of the leading causes of blindness; here, the ABCB5 protein is identified as a marker of…”
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New insights on the risk for cardiovascular disease in African Americans: the role of added sugars by Saab, Karim R, Kendrick, Jessica, Yracheta, Joseph M, Lanaspa, Miguel A, Pollard, Maisha, Johnson, Richard J

“…African Americans are at increased risk for cardiovascular and metabolic diseases, including obesity, high BP, diabetes, CKD, myocardial infarction, and…”
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Thrombotic Microangiopathy in the Setting of HIV Infection: A Case Report and Review of the Differential Diagnosis and Therapy by Saab, Karim R, Elhadad, Sonia, Copertino, Dennis, Laurence, Jeffrey

“…Before the modern era of HIV/AIDS therapeutics, which enabled a cascade of early recognition of infection, prompt initiation of effective antiretroviral…”
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ABCB5-Targeted Chemoresistance Reversal Inhibits Merkel Cell Carcinoma Growth by Kleffel, Sonja, Lee, Nayoung, Lezcano, Cecilia, Wilson, Brian J., Sobolewski, Kristine, Saab, Karim R., Mueller, Hansgeorg, Zhan, Qian, Posch, Christian, Elco, Christopher P., DoRosario, Andrew, Garcia, Sarah S., Thakuria, Manisha, Wang, Yaoyu E., Wang, Linda C., Murphy, George F., Frank, Markus H., Schatton, Tobias

“…Merkel cell carcinoma (MCC) is a highly aggressive neuroendocrine skin cancer with profound but poorly understood resistance to chemotherapy, which poses a…”
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Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition by ORR, Wayne S, DENBO, Jason W, SAAB, Karim R, MYERS, Adrianne L, NG, Catherine Y, JUNFANG ZHOU, MORTON, Christopher L, PFEFFER, Lawrence M, DAVIDOFF, Andrew M

“…Nuclear factor-κB (NF-κB) has been implicated in tumor cell proliferation and survival and in tumor angiogenesis. We sought to evaluate the effects of…”
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Retraction notice to “Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-κB inhibition” by Orr, Wayne S., MD, Denbo, Jason W., MD, Saab, Karim R., MD, Myers, Adrianne L., MD, Ng, Catherine Y., MS, Zhou, Junfang, MD, Morton, Christopher L., BS, Pfeffer, Lawrence M., PhD, Davidoff, Andrew M., MD

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RETRACTED: Liposome-encapsulated curcumin suppresses neuroblastoma growth through nuclear factor-kappa B inhibition by Orr, Wayne S., MD, Denbo, Jason W., MD, Saab, Karim R., MD, Myers, Adrianne L., MD, Ng, Catherine Y., MS, Zhou, Junfang, MD, Morton, Christopher L., BS, Pfeffer, Lawrence M., PhD, Davidoff, Andrew M., MD

“…This article has been retracted: please see Elsevier Policy on Article Withdrawal ( http://www.elsevier.com/locate/withdrawalpolicy ). This article has been…”
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Curcumin potentiates the radiosensitivity of rhabdomyosarcoma by suppressing induction of NF-KappaB activity by Orr, W. Shannon, MD, Denbo, Jason W., MD, Saab, Karim R., MD, Ng, Catherine Y., MS, Wu, Jianrong, PhD, Morton, Christopher L., BSc, Pfeffer, Lawrence M., PhD, Davidoff, Andrew M., MD, FACS

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ABCB5 maintains melanoma-initiating cells through a pro-inflammatory cytokine signaling circuit by Wilson, Brian J., Saab, Karim R., Ma, Jie, Schatton, Tobias, Pütz, Pablo, Zhan, Qian, Murphy, George F., Gasser, Martin, Waaga-Gasser, Ana Maria, Frank, Natasha Y., Frank, Markus H.

“…The drug efflux transporter ABCB5 identifies cancer stem-like cells (CSC) in diverse human malignancies, where its expression is associated with clinical…”
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Abstract 243: ABCB5 is functionally required for melanoma growth by Wilson, Brian J., Saab, Karim R., Schatton, Tobias, Ma, Jie, Murphy, George F., Gasser, Martin, Waaga-Gasser, Ana Maria, Frank, Natasha Y., Frank, Markus H.

“…Abstract Melanoma remains a disease with relatively few beneficial treatments currently available, for late-stage patients. The ATP-binding cassette (ABC)…”
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ABCB5 is a limbal stemcell gene required for corneal development and repair by Ksander, Bruce R, Kolovou, Paraskevi E, Wilson, Brian J, Saab, Karim R, Guo, Qin, Ma, Jie, McGuire, Sean P, Gregory, Meredith S, Vincent, William J B, Perez, Victor L, Cruz-Guilloty, Fernando, Kao, Winston W Y, Call, Mindy K, Tucker, Budd A, Zhan, Qian, Murphy, George F, Lathrop, Kira L, Alt, Clemens, Mortensen, Luke J, Lin, Charles P, Zieske, James D, Frank, Markus H, Frank, Natasha Y

“…Corneal epithelial homeostasis and regeneration are sustained by limbal stem cells (LSCs), and LSC deficiency is a major cause of blindness worldwide…”
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Curcumin Potentiates Rhabdomyosarcoma Radiosensitivity by Suppressing NF-[kappa]B Activity by Orr, W. Shannon, Denbo, Jason W, Saab, Karim R, Ng, Catherine Y, Wu, Jianrong, Li, Kui, Garner, Jo Meagan, Morton, Christopher L, Du, Ziyun, Pfeffer, Lawrence M, Davidoff, Andrew M

“…Ionizing radiation (IR) is an essential component of therapy for alveolar rhabdomyosarcoma. Nuclear factor-kappaB (NF-[kappa][BETA]) transcription factors are…”
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