Search Results - "Saab, Aiman S"

Myelin dynamics: protecting and shaping neuronal functions by Saab, Aiman S, Nave, Klaus-Armin

“…•Cytosolic channels in the myelin sheath are critical for axonal integrity.•Activity-dependent vesicular release and transmitter signaling regulate…”
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Oligodendroglial NMDA Receptors Regulate Glucose Import and Axonal Energy Metabolism by Saab, Aiman S., Tzvetavona, Iva D., Trevisiol, Andrea, Baltan, Selva, Dibaj, Payam, Kusch, Kathrin, Möbius, Wiebke, Goetze, Bianka, Jahn, Hannah M., Huang, Wenhui, Steffens, Heinz, Schomburg, Eike D., Pérez-Samartín, Alberto, Pérez-Cerdá, Fernando, Bakhtiari, Davood, Matute, Carlos, Löwel, Siegrid, Griesinger, Christian, Hirrlinger, Johannes, Kirchhoff, Frank, Nave, Klaus-Armin

“…Oligodendrocytes make myelin and support axons metabolically with lactate. However, it is unknown how glucose utilization and glycolysis are adapted to the…”
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Neurotransmitter-triggered transfer of exosomes mediates oligodendrocyte-neuron communication by Frühbeis, Carsten, Fröhlich, Dominik, Kuo, Wen Ping, Amphornrat, Jesa, Thilemann, Sebastian, Saab, Aiman S, Kirchhoff, Frank, Möbius, Wiebke, Goebbels, Sandra, Nave, Klaus-Armin, Schneider, Anja, Simons, Mikael, Klugmann, Matthias, Trotter, Jacqueline, Krämer-Albers, Eva-Maria

“…Reciprocal interactions between neurons and oligodendrocytes are not only crucial for myelination, but also for long-term survival of axons. Degeneration of…”
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Direct vascular contact is a hallmark of cerebral astrocytes by Hösli, Ladina, Zuend, Marc, Bredell, Gustav, Zanker, Henri S., Porto de Oliveira, Carlos Eduardo, Saab, Aiman S., Weber, Bruno

“…Astrocytes establish extensive networks via gap junctions that allow each astrocyte to connect indirectly to the vasculature. However, the proportion of…”
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Non-Canonical Control of Neuronal Energy Status by the Na+ Pump by Baeza-Lehnert, Felipe, Saab, Aiman S., Gutiérrez, Robin, Larenas, Valeria, Díaz, Esteban, Horn, Melanie, Vargas, Miriam, Hösli, Ladina, Stobart, Jillian, Hirrlinger, Johannes, Weber, Bruno, Barros, L. Felipe

“…Neurons have limited intracellular energy stores but experience acute and unpredictable increases in energy demand. To better understand how these cells…”
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Long-term In Vivo Calcium Imaging of Astrocytes Reveals Distinct Cellular Compartment Responses to Sensory Stimulation by Stobart, Jillian L, Ferrari, Kim David, Barrett, Matthew J P, Stobart, Michael J, Looser, Zoe J, Saab, Aiman S, Weber, Bruno

“…Abstract Localized, heterogeneous calcium transients occur throughout astrocytes, but the characteristics and long-term stability of these signals,…”
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Monitoring ATP dynamics in electrically active white matter tracts by Trevisiol, Andrea, Saab, Aiman S, Winkler, Ulrike, Marx, Grit, Imamura, Hiromi, Möbius, Wiebke, Kusch, Kathrin, Nave, Klaus-Armin, Hirrlinger, Johannes

“…In several neurodegenerative diseases and myelin disorders, the degeneration profiles of myelinated axons are compatible with underlying energy deficits…”
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Decoupling astrocytes in adult mice impairs synaptic plasticity and spatial learning by Hösli, Ladina, Binini, Noemi, Ferrari, Kim David, Thieren, Laetitia, Looser, Zoe J., Zuend, Marc, Zanker, Henri S., Berry, Stewart, Holub, Martin, Möbius, Wiebke, Ruhwedel, Torben, Nave, Klaus-Armin, Giaume, Christian, Weber, Bruno, Saab, Aiman S.

“…The mechanisms by which astrocytes modulate neural homeostasis, synaptic plasticity, and memory are still poorly explored. Astrocytes form large intercellular…”
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Distinct signatures of calcium activity in brain mural cells by Glück, Chaim, Ferrari, Kim David, Binini, Noemi, Keller, Annika, Saab, Aiman S, Stobart, Jillian L, Weber, Bruno

“…Pericytes have been implicated in various neuropathologies, yet little is known about their function and signaling pathways in health. Here, we characterized…”
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Deficits in mitochondrial TCA cycle and OXPHOS precede rod photoreceptor degeneration during chronic HIF activation by Todorova, Vyara, Stauffacher, Mia Fee, Ravotto, Luca, Nötzli, Sarah, Karademir, Duygu, Ebner, Lynn J A, Imsand, Cornelia, Merolla, Luca, Hauck, Stefanie M, Samardzija, Marijana, Saab, Aiman S, Barros, L Felipe, Weber, Bruno, Grimm, Christian

“…Major retinal degenerative diseases, including age-related macular degeneration, diabetic retinopathy and retinal detachment, are associated with a local…”
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Bergmann Glial AMPA Receptors Are Required for Fine Motor Coordination by Saab, Aiman S., Neumeyer, Alexander, Jahn, Hannah M., Cupido, Alexander, Šimek, Antonia A. M., Boele, Henk-Jan, Scheller, Anja, Le Meur, Karim, Götz, Magdalena, Monyer, Hannah, Sprengel, Rolf, Rubio, Maria E., Deitmer, Joachim W., De Zeeuw, Chris I., Kirchhoff, Frank

“…The impact of glial neurotransmitter receptors in vivo is still elusive. In the cerebellum, Bergmann glial (BG) cells express…”
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Intravitreal AAV-Delivery of Genetically Encoded Sensors Enabling Simultaneous Two-Photon Imaging and Electrophysiology of Optic Nerve Axons by Looser, Zoe J, Barrett, Matthew J P, Hirrlinger, Johannes, Weber, Bruno, Saab, Aiman S

“…Myelination of axons by oligodendrocytes is a key feature of the remarkably fast operating CNS. Oligodendrocytes not only tune axonal conduction speed but are…”
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Genetic background affects human glial fibrillary acidic protein promoter activity by Bai, Xianshu, Saab, Aiman S, Huang, Wenhui, Hoberg, Isolde K, Kirchhoff, Frank, Scheller, Anja

“…The human glial fibrillary acidic protein (hGFAP) promoter has been used to generate numerous transgenic mouse lines, which has facilitated the analysis of…”
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Electron Microscopy of the Mouse Central Nervous System by Möbius, Wiebke, Cooper, Benjamin, Kaufmann, Walter A., Imig, Cordelia, Ruhwedel, Torben, Snaidero, Nicolas, Saab, Aiman S., Varoqueaux, Frédérique

“…The high degree of similarity between mouse and human physiology and genomes makes mice the animal model of choice to study the functions and dysfunctions of…”
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Arousal-induced cortical activity triggers lactate release from astrocytes by Zuend, Marc, Saab, Aiman S., Wyss, Matthias T., Ferrari, Kim David, Hösli, Ladina, Looser, Zoe J., Stobart, Jillian L., Duran, Jordi, Guinovart, Joan J., Barros, L. Felipe, Weber, Bruno

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The role of myelin and oligodendrocytes in axonal energy metabolism by Saab, Aiman S, Tzvetanova, Iva D, Nave, Klaus-Armin

“…Highlights • Myelin is an insulator that can shield long axons from rapid access to metabolites. • Oligodendrocytes can ‘feed’ axons with glycolysis products…”
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Shear-stress sensing by PIEZO1 regulates tendon stiffness in rodents and influences jumping performance in humans by Passini, Fabian S., Jaeger, Patrick K., Saab, Aiman S., Hanlon, Shawn, Chittim, Nicole A., Arlt, Matthias J., Ferrari, Kim David, Haenni, Dominik, Caprara, Sebastiano, Bollhalder, Maja, Niederöst, Barbara, Horvath, Aron N., Götschi, Tobias, Ma, Shang, Passini-Tall, Bettina, Fucentese, Sandro F., Blache, Ulrich, Silván, Unai, Weber, Bruno, Silbernagel, Karin Grävare, Snedeker, Jess G.

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Glycolytic oligodendrocytes maintain myelin and long-term axonal integrity by Fünfschilling, Ursula, Supplie, Lotti M., Mahad, Don, Boretius, Susann, Saab, Aiman S., Edgar, Julia, Brinkmann, Bastian G., Kassmann, Celia M., Tzvetanova, Iva D., Möbius, Wiebke, Diaz, Francisca, Meijer, Dies, Suter, Ueli, Hamprecht, Bernd, Sereda, Michael W., Moraes, Carlos T., Frahm, Jens, Goebbels, Sandra, Nave, Klaus-Armin

“…After myelination, oligodendrocytes are able to survive without mitochondrial respiration, suggesting that they can switch to aerobic glycolysis and release…”
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A mechanism for myelin injury by Saab, Aiman S., Nave, Klaus-Armin

“…The cells that insulate neuronal processes with a myelin membrane sheath are damaged during stroke. Data now show that an influx of calcium ions mediated by…”
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Oligodendrocyte–axon metabolic coupling is mediated by extracellular K+ and maintains axonal health by Looser, Zoe J., Faik, Zainab, Ravotto, Luca, Zanker, Henri S., Jung, Ramona B., Werner, Hauke B., Ruhwedel, Torben, Möbius, Wiebke, Bergles, Dwight E., Barros, L. Felipe, Nave, Klaus-Armin, Weber, Bruno, Saab, Aiman S.

“…The integrity of myelinated axons relies on homeostatic support from oligodendrocytes (OLs). To determine how OLs detect axonal spiking and how rapid axon–OL…”
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