Search Results - "Sałaciak, Kinga"

The Antiarrhythmic and Hypotensive Effects of S-61 and S-73, the Pyrrolidin-2-one Derivatives with α1-Adrenolytic Properties by Lustyk, Klaudia, Sałaciak, Kinga, Siwek, Agata, Sapa, Jacek, Zaręba, Paula, Gałuszka, Adam, Pytka, Karolina

“…Heart rhythm abnormalities are a cause of many deaths worldwide. Unfortunately, the available antiarrhythmic drugs show limited efficacy and proarrhythmic…”
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Revisiting the sigma-1 receptor as a biological target to treat affective and cognitive disorders by Sałaciak, Kinga, Pytka, Karolina

“…•Sigma-1 receptors are unique therapeutic targets modulating the activity of various proteins and systems in the organism.•Preclinical studies reported that…”
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Biased agonism in drug discovery: Is there a future for biased 5-HT1A receptor agonists in the treatment of neuropsychiatric diseases? by Sałaciak, Kinga, Pytka, Karolina

“…Serotonin (5-HT) is one of the fundamental neurotransmitters that contribute to the information essential for an organism's normal, physiological function…”
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Serotonin receptors in depression and anxiety: Insights from animal studies by Żmudzka, Elżbieta, Sałaciak, Kinga, Sapa, Jacek, Pytka, Karolina

“…Serotonin regulates many physiological processes including sleep, appetite, and mood. Thus, serotonergic system is an important target in the treatment of…”
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Synthesis and Evaluation of the Antidepressant-like Properties of HBK-10, a Novel 2-Methoxyphenylpiperazine Derivative Targeting the 5-HT1A and D2 Receptors by Sałaciak, Kinga, Malikowska-Racia, Natalia, Lustyk, Klaudia, Siwek, Agata, Głuch-Lutwin, Monika, Kazek, Grzegorz, Popiół, Justyna, Sapa, Jacek, Marona, Henryk, Żelaszczyk, Dorota, Pytka, Karolina

“…The increasing number of patients reporting depressive symptoms requires the design of new antidepressants with higher efficacy and limited side effects. As…”
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HBK-17, a 5-HT1A Receptor Ligand With Anxiolytic-Like Activity, Preferentially Activates ß-Arrestin Signaling by Pytka, Karolina, Głuch-Lutwin, Monika, Żmudzka, Elżbieta, Sałaciak, Kinga, Siwek, Agata, Niemczyk, Katarzyna, Walczak, Maria, Smolik, Magdalena, Olczyk, Adrian, Gałuszka, Adam, Śmieja, Jarosław, Filipek, Barbara, Sapa, Jacek, Kołaczkowski, Marcin, Pańczyk, Katarzyna, Waszkielewicz, Anna, Marona, Henryk

“…Numerous studies have proven that both stimulation and blockade of 5-HT 1A and the blockade of 5-HT 7 receptors might cause the anxiolytic-like effects. Biased…”
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The Calcium/Calmodulin-Dependent Kinases II and IV as Therapeutic Targets in Neurodegenerative and Neuropsychiatric Disorders by Sałaciak, Kinga, Koszałka, Aleksandra, Żmudzka, Elżbieta, Pytka, Karolina

“…CaMKII and CaMKIV are calcium/calmodulin-dependent kinases playing a rudimentary role in many regulatory processes in the organism. These kinases attract…”
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The selective 5-HT1A receptor biased agonists, F15599 and F13714, show antidepressant-like properties after a single administration in the mouse model of unpredictable chronic mild stress by Głuch-Lutwin, Monika, Sałaciak, Kinga, Gawalska, Alicja, Jamrozik, Marek, Sniecikowska, Joanna, Newman-Tancredi, Adrian, Kołaczkowski, Marcin, Pytka, Karolina

“…Rationale The prevalence of depression is ever-increasing throughout the population. However, available treatments are ineffective in around one-third of…”
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Memory impairments in rodent depression models: A link with depression theories by Sałaciak, Kinga, Koszałka, Aleksandra, Lustyk, Klaudia, Żmudzka, Elżbieta, Jagielska, Angelika, Pytka, Karolina

“…More than 80% of depressed patients struggle with learning new tasks, remembering positive events, or concentrating on a single topic. These neurocognitive…”
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HBK-15, a Multimodal Compound, Showed an Anxiolytic-Like Effect in Rats by Lustyk, Klaudia, Sałaciak, Kinga, Jakubczyk, Magdalena, Jastrzębska-Więsek, Magdalena, Partyka, Anna, Wesołowska, Anna, Marona, Henryk, Pytka, Karolina

“…Anxiety is a common mental disorder, and its prevalence has lately increased because of the COVID-19 pandemic. Unfortunately, the available anxiolytics are…”
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The 5-HT1A receptor biased agonist, NLX-204, shows rapid-acting antidepressant-like properties and neurochemical changes in two mouse models of depression by Głuch-Lutwin, Monika, Sałaciak, Kinga, Pytka, Karolina, Gawalska, Alicja, Jamrozik, Marek, Śniecikowska, Joanna, Kołaczkowski, Marcin, Depoortère, Ronan Y., Newman-Tancredi, Adrian

“…Activation of cortical serotonin 5-HT1A receptors may be a promising strategy to achieve rapid-acting antidepressant (RAAD) activity. NLX-204 is a selective…”
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The Antiarrhythmic Activity of Novel Pyrrolidin-2-one Derivative S-75 in Adrenaline-Induced Arrhythmia by Lustyk, Klaudia, Sałaciak, Kinga, Zaręba, Paula, Siwek, Agata, Sapa, Jacek, Pytka, Karolina

“…Arrhythmia is a quivering or irregular heartbeat that can often lead to blood clots, stroke, heart failure, and other heart-related complications. The limited…”
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Potential Anti-Amnesic Activity of a Novel Multimodal Derivative of Salicylamide, JJGW08, in Mice by Żmudzka, Elżbieta, Lustyk, Klaudia, Sałaciak, Kinga, Siwek, Agata, Jaśkowska, Jolanta, Kołaczkowski, Marcin, Sapa, Jacek, Pytka, Karolina

“…Memory impairments constitute a significant problem worldwide, and the COVID-19 pandemic dramatically increased the prevalence of cognitive deficits. Patients…”
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HBK-10, A Compound with α1-Adrenolytic Properties, Showed Antiarrhythmic and Hypotensive Effects in Rats by Lustyk, Klaudia, Sałaciak, Kinga, Siwek, Agata, Filipek, Barbara, Sapa, Jacek, Marona, Henryk, Żelaszczyk, Dorota, Pytka, Karolina

“…Arrhythmia, an irregular heartbeat, might be a life-threatening condition but also a risk factor for stroke or worsen the prognosis after myocardial…”
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Pitolisant protects mice chronically treated with corticosterone from some behavioral but not metabolic changes in corticosterone-induced depression model by Kotańska, Magdalena, Mika, Kamil, Sałaciak, Kinga, Wheeler, Lee, Sapa, Jacek, Kieć-Kononowicz, Katarzyna, Pytka, Karolina

“…Histamine H3 receptor ligands may have antidepressant and anxiolytic effects. They can also compensate for metabolic disorders, which affect glucose or…”
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The antidepressant-like activity of chiral xanthone derivatives may be mediated by 5-HT1A receptor and β-arrestin signalling by Sałaciak, Kinga, Głuch-Lutwin, Monika, Siwek, Agata, Szafarz, Małgorzata, Kazek, Grzegorz, Bednarski, Marek, Nowiński, Leszek, Mitchell, Emma, Jastrzębska-Więsek, Magdalena, Partyka, Anna, Wesołowska, Anna, Kołaczkowski, Marcin, Szkaradek, Natalia, Marona, Henryk, Sapa, Jacek, Pytka, Karolina

“…Background: Our previous studies showed that xanthone derivatives with N-(2-methoxyphenyl)piperazine fragment have an affinity to the 5-HT1A receptor and show…”
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Biased agonism in drug discovery: Is there a future for biased 5-HT 1A receptor agonists in the treatment of neuropsychiatric diseases? by Sałaciak, Kinga, Pytka, Karolina

“…Serotonin (5-HT) is one of the fundamental neurotransmitters that contribute to the information essential for an organism's normal, physiological function…”
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Laetiporus sulphureus – CHEMICAL COMPOSITION AND MEDICINAL VALUE by Sułkowska-Ziaja, Katarzyna, Muszyńska, Bożena, Gawalska, Alicja, Sałaciak, Kinga

“…The higher fungi are a rich source of chemical compounds with multi-directional therapeutic and pro-health effects. This review summarizes the results of the…”
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HBK-10, A Compound with α[sub.1]-Adrenolytic Properties, Showed Antiarrhythmic and Hypotensive Effects in Rats by Lustyk, Klaudia, Sałaciak, Kinga, Siwek, Agata, Filipek, Barbara, Sapa, Jacek, Marona, Henryk, Żelaszczyk, Dorota, Pytka, Karolina

“…Arrhythmia, an irregular heartbeat, might be a life-threatening condition but also a risk factor for stroke or worsen the prognosis after myocardial…”
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HBK‑10, A 5‑HT1A AND D2 RECEPTOR ANTAGONIST, SHOWS ANTIPSYCHOTIC‑LIKE ACTIVITY IN MICE by Lustyk, Klaudia, Idlin, Nathalie, Sałaciak, Kinga, Żelaszczyk, Dorota, Marona, Henryk, Pytka, Karolina

“…Schizophrenia affects around 24 million people worldwide. In addition to positive and negative symptoms, the majority of patients suffer from cognitive…”
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