Correcting influence of vitamin E short chain derivatives on lipid peroxidation, liver cell membrane, and chromatin structure when rats are exposed to embichin

Embikhin causes activation of LPO processes in endoplasmic reticulum and in nuclear chromatine fractions of rat liver cells. The latter is accompanied by the impairment of repressive and active nuclear chromatine fractions structure. Derivate of vitamin E in these conditions renders correcting actio...

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Bibliographic Details
Published in:	Ukrains'kyi biokhimichnyi zhurnal (1999 ) Vol. 72; no. 2; p. 56
Main Authors:	Kovalenko, V M, Byshovets', T F, Hubs'kyĭ, Iu I, Levyts'kyĭ, Ie L, Shaiakhmetova, H M, Marchenko, O M, Voloshyna, O S, Saĭfetdinova, H A, Okhrimenko, V O, Donchenko, H V
Format:	Journal Article
Language:	Ukrainian
Published:	Ukraine 01-03-2000
Subjects:	Animals Cell Membrane - drug effects Chromatin - chemistry Lipid Peroxidation - drug effects Liver - drug effects Liver - metabolism Male Mechlorethamine - pharmacology Protein Conformation Rats Vitamin E - analogs & derivatives Vitamin E - pharmacology
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Summary:	Embikhin causes activation of LPO processes in endoplasmic reticulum and in nuclear chromatine fractions of rat liver cells. The latter is accompanied by the impairment of repressive and active nuclear chromatine fractions structure. Derivate of vitamin E in these conditions renders correcting action on parameters of lipid peroxidation in the investigated subcellular structures, testifying its positive influence on the cell heredity apparatus state. The normalizing action of tocopherol derivative on cytochromes P450 and b5 levels is shown.